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A highly selective fluorescent probe for real-time imaging of udp-glucuronosyltransferase 1a8 in living cells and tissues

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 103-111页

作者： Mingyue Zhu Zhenhao Tian Lingling Jin Xiaokui Huo Chao Wang Jingnan Cui Yan Tian Xiangge Tian Lei Feng College of Pharmacy School of MedicineKey Laboratory of Elemene Class Anti-Cancer Chinese MedicinesEngineering Laboratory of Development and Application of Traditional Chinese MedicinesHangzhou Normal UniversityHangzhou 311121China Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention College of PharmacyCollege of Integrative MedicineDalian Medical UniversityDalian 116044China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Uridine diphosphate(udp)-glucuronosyltransferases(UGTs)are enzymes involved in the biotransformation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including drugs,environmental toxicants,and ***,a novel fluorescent probe BDMP was developed based on boron-dipyrromethene(BODIPY)with high sensitivity for the detection of *** glucuronidation of BDMP not only exhibited a redemission wavelength(lex/lem=500/580 nm),but also displayed an excellent UGT1a8-dependent fluorescence signal with a good linear relationship with UGT1a8 *** on this perfect biocompatibility and cell permeability,BDMP was successfully used to image endogenous UGT1a8 in human cancer cell lines(LoVo and HCT15)in real *** addition,BDMP could also be used to visualize UGT1a8 in tumor *** results suggested that BDMP is a promising molecular tool for the investigation of UGT1a8-mediated physiological function in humans.

关键词： udp-glucuronosyltransferase 1a8 fluorescent probe subtype selectivity fluorescence imaging

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