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汽车与运动 2024年第1期 70-73页

作者：卫东(文/摄影) 不详

当把带有黄色LOGO的德国马牌uc6 FR SSR SYL安装到松石绿色车身的奔驰GLC 260L时,立刻让奔驰GLC 260L显得更加张扬和时尚,对于追求色彩靓丽的松石绿车主来说,这颜色搭配让这辆奔驰GLC 260L在街头显得更加醒目.

关键词：颜色搭配 SUV 奔驰 GLC 车身德国 uc

A MULTIGRID METHOD FOR NONLINEAR PARABOLIC PROBLEMS

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Journal of Computational Mathematics 1996年第4期14卷 363-382页

作者： x.J. Yu(Laborutory of Computational Physics, Institute of Applied Physics and ComputationalMathematics, Beijing, China) Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics Beijing China

The multigrid algorithm in [13] is developed for solving nonlinear parabolic equations arising from the finite element discretization. The computational cost of the algorithm is approximate O(NkN) where N-k is the dim... 详细信息

关键词： Th Math A MULTIGRID METHOD FOR NONLINEAR PARABOLIC PROBLEMS uc

DISTRIBUTION OF AN NcoI POLYMORPHISM IN THE LYMPHOTOXIN α GENE IN DUTCH PATIENTS WITH INFLAMATORY BOWEL DISEASES

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中华医学杂志(英文版) 1995年第10期108卷 739-742页

作者：夏冰 G Bouma JBA Grusius SGM Meuwissen AS Pena The Second Affiliated Hospital Hubei Medical University Departments of Gastroenterology.Free University Hospital Amsterdam Wuhan China the Netherlands

An Ncol restriction fragment length polymorphism in the first intron of the lymphotoxin α gene was investigated in 35 patients with Crohn’s disease, 40 patients with ulcerative colitis, and 30 unrelated healthy controls, all of Dutch origin. The results showed that no significant differences existed in the genotype frequencies of the NcoI polymorphism in the first intron of the LTα gene between ulcerative colitis patients or Crohn’s disease patients and the healthy controls. The study indicates that the NcoI polymorphism in the LTα gene can not be used as a genetic marker for the predisposition to inflammatory bowel diseases. However, since this polymorphism may control the production of tumor necrosis factor, study of this and other related tumor necrosis factor gene polymorphisms may he used as markers to identify patient subgroups and to define patient heterogeneity. Further studies are being carried out on other polymorphisms and on the relevance of LTα and TNFα haplotypes.

关键词： IBD gene DISTRIBUTION OF AN NcoI POLYMORPHISM IN THE LYMPHOTOXIN GENE IN DUTCH PATIENTS WITH INFLAMATORY BOWEL DISEASES MHC uc

Molecular Beam Epitaxy Growth of Tetragonal FeS Films on SrTiO3(001) Substrates

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Chinese Physics Letters 2017年第8期34卷 125-128页

作者：赵琨林海城黄万通胡小鹏陈曦薛其坤季帅华 State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 Collaborative Innovation Center of Quantum Matter Beijing 100084

We report the successful growth of the tetragonal FeS film with one or two unit-cell （uc） thickness on SrTiO33（001） substrates by molecular beam epitaxy. Large lattice constant mismatch with the substrate leads to high density of defects in single-uc FeS, while it has been significantly reduced in the double-uc thick film due to the lattice relaxation. The scanning tunneling spectra on the surface of the FeS thin film reveal the electronic doping effect of single-uc FeS from the substrate. In addition, at the Fermi level, the energy gaps of approximately 1.5？meV are observed in the films of both thicknesses at 4.6？K and below. The absence of coherence peaks of gap spectra may be related to the preformed Cooper-pairs without phase coherence.

关键词： FeS uc Substrates Molecular Beam Epitaxy Growth of Tetragonal FeS Films on SrTiO3

Superconductivity above 28K in single unit cell FeSe ?lms interfaced with GaO_(2-δ) layer on NdGaO_3(110)

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Science Bulletin 2019年第8期64卷 490-494页

作者： Haohao Yang Guanyu Zhou Yuying Zhu Guan-Ming Gong Qinghua Zhang Menghan Liao Zheng Li Cui Ding Fanqi Meng Mohsin Rafique Heng Wang Lin Gu Ding Zhang Lili Wang Qi-Kun Xue State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Laboratory for Advanced Materials & Electron Microscopy Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter

The discovery of high temperature superconductivity in single unit cell(uc)FeSe on TiO2-δterminated perovskite SrTiO3(001)substrates[1]has attracted intensive attention on searching for new superconducting systems wi... 详细信息

关键词： Ga 110 lms interfaced with GaO Superconductivity above 28K in single unit cell FeSe layer on NdGaO3 uc

Investigation of the mechanism of upconversion luminescence in Er^(3+)/Yb^(3+) co-doped Bi_2Ti_2O_7 inverse opal

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Chinese Optics Letters 2013年第4期11卷 60-63页

作者：严冬杨正文廖佳燕吴航俊邱建备宋志国周大成杨勇尹兆益 Key Laboratory of Advanced Materials in Rare and Precious and Non-ferrous Metals Ministry of Education Key Laboratory of Advanced Materials of Yunnan Province College of Materials Science and Engineering Kunming University of Science and Technology

Three-dimensional-ordered Yb/Er co-doped Bi2Ti207 inverse opal, powder, and disordered reference sam- ples are prepared and their upconversion （uc） emission properties and mechanisms are investigated. Sig- nificant suppression of uc emission is detected when the photonic band-gaps overlap with Er3＋ uc green emission bands. Interestingly, green and red uc emissions follow a two-photon process in the powder sample but a three-photon one in the inverse opal.

关键词： uc co-doped Bi2Ti2O7 inverse opal Investigation of the mechanism of upconversion luminescence in Er Yb Bi Ti

Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

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Precision Clinical Medicine 2023年第4期6卷 213-225页

作者： Fengqin Zhu Dehuai Jing Huihui Zhou Zongjing Hu Yan Wang Guiyuan Jin Yonghong Yang Guangxi Zhou Department of Gastroenterology Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China Medical Research Center Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Background:Ulcerative colitis(uc)is a progressive chronic inflammatory disorder.Neutrophils play a critical role in regulating in-testinal mucosal homeostasis in uc.Spleen tyrosine kinase(Syk)is involved in several inflammatory diseases.Here,we evaluated the effects and underlying mechanisms of Syk on neutrophil immune-responses in uc.Methods:Syk expression in the colonic tissues of patients with uc was determined using quantitative reverse transcription-polymerase chain reaction(qRT-PCR),western blotting,and immunohistochemistry.Colonic biopsies from patients with uc were obtained for single-cell RNA-sequencing.Neutrophils isolated from peripheral blood were pre-treated with R788(a Syk inhibitor)and gene differences were determined using RNA sequencing.Neutrophil functions were analyzed using qRT-PCR,flow cytometry,and Transwell assay.R788 was administered daily to mice with dextran sulfate sodium(DSS)-induced colitis to verify the effects of Syk on intestinal inflammation.Results:Syk expression was increased in inflamed mucosa and neutrophils of patients with uc and positively correlated with dis-ease activity.Pharmacological inhibition of Syk in neutrophils decreased the production of pro-inflammatory cytokines,chemokines,neutrophil extracellular traps,reactive oxygen species,and myeloperoxidase.Apoptosis and migration of neutrophils were sup-pressed by Syk blockade.Syk blockade ameliorated mucosal inflammation in DSS-induced murine colitis by inhibiting neutrophil-associated immune responses.Mechanistically,Syk regulated neutrophil immune-responses via the mammalian target of rapamycin kinase/rubicon-like autophagy enhancer-dependent autophagy pathway.Conclusions:Our findings indicate that Syk facilitates specific neutrophil functional responses to mucosal inflammation in uc,and its inhibition ameliorates mucosal inflammation in DSS-induced murine colitis,suggesting its potential as a novel therapeutic target for uc treatment.

关键词： Syk uc neutrophils autophagy

Enhancement of the up-conversion luminescence of ZnO:Yb3+/Er3+ by photonic crystals

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Optoelectronics Letters 2019年第3期15卷 195-199页

作者：张晓慧张海明李育洁 School of Science Tianjin Polytechnic UniversityTianjin300387China Physics Department Tianjin University Renai CollegeTianjin300072China

The opal photonic crystals(PCs) were assembled by vertical deposition of polystyrene microspheres(PS), in which Yb3+, Er3+ co-doped ZnO powders were deposited on the surface of PC films. The phase, structure and morphology of the obtained samples were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM) and transmission electron microscope(TEM). The performance of up-conversion photoluminescence(ucPL) was investigated by fluorescence spectrophotometer. The up-conversion(uc) emission of Zn O:Yb3+/Er3+ on the PC surface is notably enhanced when the uc emission wavelength is overlapped with the photonic bandgaps of opals, which is attributed to Bragg reflection of photonic bandgap. The results show that PCs may have potential applications in the enhancement of ucPL and optoelectronic devices.

关键词： Er uc PC ZnO Enhancement of the up-conversion luminescence of ZnO:Yb

铁苋菜对RAW 264.7细胞NLRP3及炎症因子表达的影响

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中国兽医学报 2023年第5期43卷 1019-1028页

作者：尕玉樊艺萌王惠茹魏媛媛张艳楠郝智慧中国农业大学动物医学院北京100193

利用中药网络药理学结合脂多糖(LPS)诱导RAW 264.7细胞建立的炎症模型,共同探讨铁苋菜(AAL)治疗溃疡性结肠炎(uc)的作用机制。基于文献研究并结合OMIM、Drugbank、TDD数据库筛选得到AAL以及uc相关靶标,进行GO功能分析和KEGG通路富集分... 详细信息

利用中药网络药理学结合脂多糖(LPS)诱导RAW 264.7细胞建立的炎症模型,共同探讨铁苋菜(AAL)治疗溃疡性结肠炎(uc)的作用机制。基于文献研究并结合OMIM、Drugbank、TDD数据库筛选得到AAL以及uc相关靶标,进行GO功能分析和KEGG通路富集分析。将RAW 264.7细胞分为空白对照组、LPS组、阳性药物组、铁苋菜高、中、低剂量组(900,800,700 mg/L)。观察高、中、低剂量AAL对RAW 264.7的细胞活力和细胞凋亡的影响,同时采用qRT-PCR和Western blot检测高、中、低剂量AAL对NLRP3、GSDMD、Caspase-1、ASC、IL-1β、IL-18、Muc-2、OCLN的mRNA与蛋白表达水平的影响。网络药理学结果显示AAL治疗uc主要涉及凋亡过程的负调控及PI3K-Akt信号通路等过程。体外试验显示700,800,900 mg/L AAL显著抑制LPS处理的巨噬细胞的活力,减少细胞凋亡,降低NLRP3、GSDMD、Caspase-1和ASC mRNA和蛋白的表达。以上结果表明AAL可通过抑制NLRP3/Caspase-1信号通路,减少炎症因子IL-18和IL-1β的分泌,从而减轻LPS诱导的炎症,治疗uc。

关键词：网络药理学铁苋菜 uc NLRP3/Caspase 1 RAW 264.7

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uc直营电商业务竞争战略研究

UC直营电商业务竞争战略研究

作者：赵金刚兰州大学

学位级别：硕士

B2C电商从兴起至今,发展了有20多年,随着电商市场的不断繁荣,互联网零售带来的巨大经济效益和充满诱惑的发展前景让线上零售商家充满了想象,在激烈的市场竞争中,线上的获客成本也在悄然增加。与此同时,消费者对商品种类、品质、服务和... 详细信息

B2C电商从兴起至今,发展了有20多年,随着电商市场的不断繁荣,互联网零售带来的巨大经济效益和充满诱惑的发展前景让线上零售商家充满了想象,在激烈的市场竞争中,线上的获客成本也在悄然增加。与此同时,消费者对商品种类、品质、服务和体验的要求也在不断提升。以用户为中心的新型电商模式在创新的浪潮下逐步崭露头角,中国的B2C电商模式出现多样化:抖音鲁班电商、快手金牛电商、腾讯枫叶、百度度小店、阿里uc的松塔小店等直营电商模式逐步活跃在消费者的视野当中,其巨大的发展潜力和上扬的趋势受到市场的关注。为了提升竞争优势,各大直营电商平台在品牌合作、商品引入、内容创作、用户体验、权益升级等方面不断加码,期待通过优质的供给和服务吸引更多的用户人群。uc松塔小店是嵌入在uc浏览器当中的直营电商平台,uc浏览器又叫uc Browser,是uc Mobile Limited开发于2004年的一款软件,该软件分为移动端和PC端两个版本。uc在全球主流第三方移动浏览器当中排名靠前,通过数据统计截至到2020年,uc浏览器全球注册用户数超过6亿,月度活跃用户数超4亿。uc直营电商成立于2020年7月,基于uc平台大量的用户群和信息流优势,依托阿里巴巴集团品牌优势创立的新型电商模式。随着互联网市场竞争日趋激烈,直营电商业务发展迅猛,主流用户群体以35岁以上中年和老年人为主。uc平台用户在直营电商领域的消费覆盖严重不足,资源浪费,公司业务战略不够清晰,尤其对直营电商的定位、目标群体覆盖、行业品类覆盖、差异化战略、商业模式等方面依然处于摸索阶段。对uc平台来讲,依托自身庞大的用户基础和内容优势开展直营电商业务,存在机遇也充满挑战,如何通过充分的调查研究、数据分析和业务战略制定及执行,确保uc直营电商业务能够赢得市场竞争力,这一战略的研究对uc平台整体来讲既是对新的商业模式的探索和创新,也是对uc直营电商落地可行性的充分论证,对业务长远发展具有非常重要的现实意义。为了充分挖掘uc自身所具备的优劣势,以及开展直营电商业务所面临的影响,本文在研究的过程中充分运用相关研究工具进行分析论证,针对在uc开展直营电商业务过程中面临的外部宏观环境、市场环境、行业竞争环境等通过PEST模型、CPM矩阵、波特五力模型等进行分析研究,确认uc直营电商业务所面临的外部机会与威胁;针对uc平台的核心定位、用户心智、平台资源、平台功能、发展趋势、前景、经营现状等充分分析了uc平台企业的内部环境,进而确定开展uc直营电商业务所具备的优势与劣势。文章在论证的过程中,针对uc直营电商业务发展的需要,将所面临的相关环境进行了客观科学的分析研究。针对uc直营电商所处的外部宏观环境所产生的机会、威胁,以及uc平台自身和在阿里巴巴集团内部所具备的优劣势等方面,通过数据量化的形式得出科学结论。针对外部核心因素通过EFE矩阵进行了分析,得出加权分数为2.88分,针对uc平台企业内部核心因素通过IFE矩阵进行了分析,得出加权分数为2.73分,通过以上两项得分并进行对比后得出,开展直营电商业务所面临的外部机会大于威胁,企业内部所具备的优势大于劣势。然后对外部机会与威胁、自身优势与劣势通过SWOT矩阵进行了组合分析,制定出开展uc直营电商业务的备选战略,针对备选战略通过QSPM矩阵进行分析,最终优选出uc直营电商业务要想取得竞争优势必须走差异化路线,战略选择为“差异化竞争战略”。针对优选的“差异化竞争战略”,在落地实施方面,结合uc直营电商业务特色和同行业竞争对手业务策略,制定出4项措施:客户服务差异化、平台产品差异化、营销差异化、渠道差异化;战略的落地离不开职能战略的保障,所以在职能战略实施方面制定出5项保障措施:平台商品质量、平台技术研发、平台品牌、平台营销、人力资源;最后针对uc直营电商业务差异化竞争战略落地的风险问题,提出了控制措施,基于以上措施,保障uc直营电商业务的竞争优势地位。

关键词： uc 直营电商差异化战略竞争战略