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u1 snrnp proteins promote proximal alternative polyadenylation sites by directly interacting with 3'end processing core factors

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Journal of Molecular Cell Biology 2022年第8期14卷 29-42页

作者： Zhijie Hu Mengxia Li Zhanfeng Huo Liutao Chen Susu Liu Ke Deng Xin Lu Shangwu Chen Yonggui Fu Anlong Xu State Key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityHigher Education Mega CenterGuangzhou 510006China School of Life Sciences Beĳing University of Chinese MedicineBeĳing 100029China

In eukaryotic cells,both alternative splicing and alternative polyadenylation(APA)play essential roles in the gene regulation network.u1 small ribonucleoprotein particle(u1 snrnp)is a major component of spliceosome,and u1 snrnp complex can suppress proximal APA sites through crosstalking with 3end processing ***,here we show that both knockdown and overexpression of SNRPA,SNRPC,snrnp70,and SNRPD2,the u1 snrnp proteins,promote the usage of proximal APA sites at the transcriptome ***70 can drive the phase transition of PABPN1 from droplet to aggregate,which may reduce the repressive effects of PABPN1 on the proximal APA ***,snrnp70 can also promote the proximal APA sites by recruiting CPSF6,suggesting that the function of CPSF6 on APA is related with other RNA-binding proteins and cell ***,these results reveal that,on the contrary to u1 snrnp complex,the free proteins of u1 snrnp complex can promote proximal APA sites through the interaction with 3end processing machinery.

关键词： u1 snrnp 3'end processing factors alternative polyadenylation phase separation

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u1 small nuclear ribonucleoprotein is essential for early larval development in silkworm, Bombyx mori

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Insect Science 2022年第2期29卷 379-387页

作者： Xiaoqian Zhang Dehong Yang Xu Yang Xinran Zhang Yong Zhang Yongping Huang Shengxiang Zhang Zulian Liu College Forestry Shangdong Agriculture UniversityShangdong ProvinceTaianChina Key Laboratory of Insect Developmental and Evolutionary Biology Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina Soochow university SuzhouJiangsu ProvinceChina

u1 small nuclear ribonucleoproteins(u1 snrnp)associates with 5ʹsplice sites in the form of ribonucleoprotein particles and is highly conserved among *** physiological functions of u1 snrnp in a lepidopteran model insect Bombyx mori is mostly ***,we showed that u1 snrnp plays an important role in the development of *** of u1 snrnp in silkworm showed either delayed or stationary 1st instar larva development compared with the wild-type group.u1 snrnp deletion mutants exhibited abnormal cellular phenotypes with enlarged cell nucleus,scant cytoplasm and enlarged ***-seq analysis revealed that genes involved in metabolic pathway,biosynthesis of secondary metabolites and steroid hormone biosynthesis were significantly affected by u1 snrnp *** together,our study suggests that u1 snrnp homeostasis plays an important role in silkworm development.

关键词： CRISPR/Cas9 development ecdysone silkworm u1 snrnp

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CircTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4

CircTulp4 functions in Alzheimer's disease pathogenesis by r...

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中国生物化学与分子生物学会2019年全国学术会议暨学会...

作者： Nana Ma Jun Wan Shenzhen Key Laboratory for Neuronal Structural Biology Biomedical Research InstituteShenzhen Peking University-The Hong Kong University of Science and Technology Medical Center Division of Life Science The Hong Kong University of Science and Technology

Alzheimer’s disease(AD)—one of the most common neurodegenerative diseases worldwide—impairs cognition, memory, and language ability and causes dementia. However, AD pathogenesis remains poorly elucidated. Recently, a potential link between AD and circular RNAs(circRNAs) has been uncovered, but only a few circRNAs that might be involved in AD have been identified. Here, we systematically investigated circRNAs in the APP/PS1 model mouse brain through deep RNAsequencing. We report that circRNAs are markedly enriched in the brain and that several circRNAs exhibit differential expression between wild-type and APP/PS1 mice. We characterized one abundant circRNA, circTulp4, derived from Intron1 of the gene Tulp4. Our results indicate that circTulp4 predominantly localizes in the nucleus and interacts with u1 snrnp and RNA polymerase II to modulate the transcription of its parental gene, Tulp4, and thereby regulate the function of the nervous system and participate in the development of AD.

关键词： CircTulp4 Alzheimer’s disease(AD) Tulp4 Neurite length u1 snrnp

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