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Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D

World Journal of Gastroenterology 2011年第45期17卷 4987-4992页

作者： Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group Department of Infectious Diseases and Clinical Microbiology Medical School of Erciyes University Department of Infectious Diseases and Clinical Microbiology Medical School of Kocatepe University Department of Infectious Diseases and Clinical Microbiology Medical School of Akdeniz University Okmeydani Training and Research Hospital of the Ministry of Health 34384 Istanbul Turkey SB Diskapi Yildirim Beyazit Training and Research Hospital of the Ministry of Health

AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave.

关键词： Hepatitis B virus Genotype Resistance Lamivudine tyrosine-methionine-aspartate-aspartate mutation

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