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VUV Photoionization and Dissociation of tyramine and Dopamine： the Joint Experimental and Theoretical Studies

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Chinese Journal of Chemical Physics 2012年第1期25卷 11-18,I0003页

作者：郭会军叶莉莉贾良元张李东齐飞中国科学技术大学国家同步辐射实验室合肥230029

Photon induced dissociation investigations of neutral tyramine and dopamine are carried out with synchrotron vacuum uRraviolet photoionization mass spectrometry and theoretical calculations. At low photon energy, only molecular ions are measured by virtue of nearthreshold photoionization. While increasing photon energy to 11.7 eV or more, four distinct fragment ions are obtained for tyramine and dopamine, respectively. Besides, the ionization energies of tyramine and dopamine are determined to be 7.984-0.05 and 7.674-0.05 eV by measuring the photoionization efficiency curves of corresponding molecular ions. With help of density function theory calculations, the detailed fragmentation pathways are established as well. These two molecular cations have similar aminoethyl group elimination pathways, CTHsO2＋（m/z=124） and C7H8O＋（m/z=108） are supposed to be generated by the McLafferty rearrangement via γ-hydrogen （7-H） shift inducing β-fission. And CH2NH2＋ is proposed to derive from the direct fission of C7-C8 bond. Besides, the McLafferty rearrangement and the C7-C8 bond fission are validated to be dominant dissociation pathways for tyramine and dopamine cations.

关键词： tyramine Dopamine VUV photoionization Mass spectrometry Ionization energy Dissociation pathway

tyramine in Malt Beverages Interfering with Monoamine Oxidase Inhibitor Drugs

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Journal of Biosciences and Medicines 2016年第8期4卷 10-16页

作者： Naficeh Sadeghi Mohammad Reza Oveisi Behrooz Jannat Masoomeh Behzad Mannan Hajimahmoodi Esmaeel Zareakram Department of Drug and Food Control School of Pharmacy Tehran University of Medical Sciences Tehran Iran Water Health Research Ministry of Health and Medical Education Tehran Iran Halal Research Center Ministry of Health and Medical Education Tehran Iran

The objective of this review is the determination of tyramine in 13 nonalcoholic beers (Maoshaieer) of Tehran market and survey of it’s probably interaction with monoamine oxidase inhibitor drugs (MAOIs) has been investigated. tyramine was at the highest levels in Baltika (111.34 ± 8.19 μg/ml) and at the lowest level in Bitmalt (8.01 ± 2.09 μg/ml). Comparing different flavors of malt drinks, the highest tyramine content was shown for classic or normal flavor (average 72.99 ± 30.87 μg/ml), while the lowest value belonged to cantaloupe flavored drinks (average 10.55 ± 1.29 μg/ml). In our study, it is seen that there is a significant difference between import and Iranian non-alcoholic beers, the import ones has more tyramine than Iranians. A number of 10 kinds of 13 samples interact whit MAOIs in one serving (250 ml) usage 18.50 mg. The highest tyramine content of Iranian ones is 17.74 mg/250ml and for import ones is 27.83 mg/250ml.

关键词： tyramine Monoamine Oxidase Inhibitor Drugs Maoshaieer Nonalcoholic Beer

tyramine通过PKC_θ途径参与疼痛及机制研究

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Tyramine通过PKC_θ途径参与疼痛及机制研究

作者：秦文娟苏州大学

学位级别：硕士

目的:研究TAAR1(Trace amine-associated receptor 1)参与三叉神经炎性痛的可能机制;研究TAAR1影响小鼠三叉神经节神经元兴奋性的作用及信号转导机制。方法:应用western blotting及immunofluorescence方法,分别检测TAAR1在小鼠三叉神经... 详细信息

目的:研究TAAR1(Trace amine-associated receptor 1)参与三叉神经炎性痛的可能机制;研究TAAR1影响小鼠三叉神经节神经元兴奋性的作用及信号转导机制。方法:应用western blotting及immunofluorescence方法,分别检测TAAR1在小鼠三叉神经节神经元(TG)的蛋白表达及细胞定位,检测TAAR1在CFA造模后2天的蛋白表达水平。应用全细胞膜片钳技术,研究TAAR1内生性配体酪胺(tyramine)对小鼠小直径TG神经元兴奋性的改变及离子通道机制。应用行为学方法(Von Frey),研究TAAR1参与CFA三叉神经痛的发生及其分子机制。结果:本实验研究结果表明:1)在蛋白水平(western blotting、immunofluorescence),小鼠TG中有TAAR1受体的表达,且TAAR1主要在小直径神经元中表达。2)小鼠三叉神经炎性痛模型中TAAR1受体表达增多。3)小鼠TG中TAAR1功能增强后,TG神经元兴奋性增加。4)TAAR1受体的阻断剂(EPPTB)、A型钾电流特异性阻断剂(4-AP)、PKCθ的阻断剂(PKCθinhibitor protein)能够翻转由TAAR1功能增强引起的细胞兴奋性增加作用。5)行为学结果表明:注射0.1μM tyramine后,小鼠在20min出现痛觉过敏,持续至90min;给予TAAR1受体的阻断剂(EPPTB)、PKCθ阻断剂(PKCθinhibitor protein)能够抑制由TAAR1功能增强导致的痛觉过敏,然而,PKA阻断剂(KT5720)却不能改变由TAAR1功能增强导致的痛觉过敏。另外,在三叉神经炎性痛模型中TAAR1受体的阻断剂(EPPTB)能够在给药后30min缓减三叉神经炎性痛。结论:TAAR1在小鼠三叉神经炎性痛的表达增加,并且参与三叉神经炎性痛的发生。TAAR1功能增强可以增加三叉神经节神经元兴奋性,主要通过PKCθ途径影响A型钾电流来发挥作用。

关键词： TAAR1(Trace amine-associated receptor 1) 三叉神经节神经元(TG) 三叉神经炎性痛兴奋性 tyramine

正腎上腺素、Bretyliure及可卡因对干酪碱(tyramine)所致的大白鼠血压反应的作用

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药学进展 1962年第1期 24-24页

作者：杭秉■

干酪碱是一个加压药,本文以氨基甲酸乙酯麻醉的大白鼠作升压试验并探讨其作用机制,干酪碱对血压的作用是双相的,首先是一个强而短的升压,然后继之而来的为持久的升压或降压,干酪碱在重复应用后,血压反应逐渐减小,在缓慢的静脉滴注正肾... 详细信息

干酪碱是一个加压药,本文以氨基甲酸乙酯麻醉的大白鼠作升压试验并探讨其作用机制,干酪碱对血压的作用是双相的,首先是一个强而短的升压,然后继之而来的为持久的升压或降压,干酪碱在重复应用后,血压反应逐渐减小,在缓慢的静脉滴注正肾上腺素及双羟苯丙氨酸(Dibydroxyphenylalanine)可使之恢复,且可使其双相作用转为单一的升压作用。Bretylium可延长干酪碱的作用,在大剂量则反阻断之,但灌注正肾上腺素及双羟苯丙氨酸也可使之恢复,可卡因对干酪碱也具阻断作用,同样也可为灌注正肾上腺素及双羟苯丙氨酸

关键词：干酪 Bretyliure tyramine

Effect of quercetin-containing preservatives and modified atmospheric packaging on the production of biogenic amines in Pacific white shrimp(Litopenaeus vannamei)

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Aquaculture and Fisheries 2018年第6期3卷 254-259页

作者： Yunfang Qian Shengping Yang Jing-xin Ye Jing Xie College of Food Science&Technology Shanghai Ocean UniversityShanghai 201306China Shanghai Engineering Research Center of Aquatic Product Processing and Preservation Shanghai 201306China Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai 201306China National Experimental Teaching Demonstration Center for Food Science and Engineering(Shanghai Ocean University) Shanghai 201306China

To investigate the productions of biogenic amines(BAs)in Pacific white shrimp treated by compound preservatives(P,0.05 g/L quercetin,0.025 g/L 4-hexylresorcinol,and 0.025 g/L cinnamic acid)in combination with modified atmosphere packaging(M,80% CO_(2)/10% O_(2)/10% N_(2)),four groups of samples treated with or without preservatives and alone or in combination with modified atmosphere packaging(A,A+P,M,M+P)during storage at 4℃for 12 days were *** BAs increased in all samples,especially,putrescine and *** inhibited the increase of most BAs(except for tyramine)and psychrotrophic bacterial *** inhibitory effect of the compound preservatives on bacterial growth and BAs was limited in aerobically-and MAP-stored samples,but they retarded the production of tyramine,which accumulated more rapidly in *** total BAs and bacterial counts were found in sample M+P(78.3 mg/kg and 5.82 log cfu/g,day 12),indicating that the combined treatment of the preservatives and MAP could reduce the risk of disorders caused by BAs.

关键词： Pacific white shrimp Biogenic amines tyramine Quercetin-containing preservatives

AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans

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Biophysics Reports 2018年第1期4卷 17-24页

作者： Jiajun Fu Haining Zhang Wenming Huang Xinyu Zhu Yi Sheng Eli Song Tao Xu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology

Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gai/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding ***-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.

关键词： C. elegans TYRA-2 receptor AIM interneurons Peripheral feeding regulation tyramine

Mutagenicities of 22 Kinds of Foods After Nitrite Treatment

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Military Medical Research 1986年第1期 69-75页

作者：印木泉 Department of Military Hygiene Second Military Medical College Shanghai

The mutagenicities of 22 kinds of foods,including soy sauce,fish sauce,shrimp paste,sausages,sundried fishes,rice cracker,deep fried pork skin,salted vegetable and spices after nitrite treatment,were detected by meansof Ames test with *** assay was employed on Sal-monella typhimurium TA100,and meanwhile,the validity of each experi-ment was checked by using the known mutagen,AF-2,as the positivecontrol.16 kinds of foods showed marked direct-acting mutagenicity towardSalmonella typhimurium TA100 after nitrite *** paste prod-uced in Bankok was the strongest one among these *** specificmutagenicity was 37000 revertants/*** amount of precursor,tyramine,in shrimp paste was estimated fromthe area of tyramine peak on HPLC by using the authentic tyramine as *** showed that one gram shrimp paste contained 439μ*** mutagenicities of foods suggested that nitrosatable precursors,suchas amine or amide,were present in foods,and they could be converted intoendogenous carcinogen,nitrosamine,in ***,detection of muta-genicities of foods has significance in preventing cancer.

关键词： nutagenicity nitrosation tyramine food