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Analgesic,anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of typhonium trilobatum ***

Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 722-726页

作者： Khadem Ali Ayesha Ashraf Nripendra Nath Biswas Biotechnology Department Biological Science SchoolChung Ang University Biotechnology and Genetic Engineering Discipline Life Science SchoolKhulna University Pharmacy Discipline Life Science SchoolKhulna University

Objective:To explore the efficacy of ethanolic leaf extract of typhonium trilobatum *** in treating diarrhea,pain and inflammation using experimental ***:In the present study,acetic acid-induced writhing,xylene-induced ear edema and castor oil-imluced diarrlieal model were used to evaluate the analgesic,anti-inflammatory and anti-diarrheal activities,*** toxicity test was carried out to fix the safe doses of the plant ***:The plant extract demonstrated a significant inhibition of writhing(P<0.01)compared with the control group in acetic acid-induced writhing test in *** extract also significantly inhibited the xylene induced ear edema formation(P<0.05).In anti-diarrheal test,the extract significantly decreased the frequency of defecation and increased the mean latent period(P<0.0l)in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body ***:These results suggest that the extract possesses significant analgesic,anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacologicl uses of this plant.

关键词： Analgesic Anti-inflammatory Anti-diarrheal typhonium trilobatum Toxicity

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The inhibition of typhonium flagelliforme Lodd. Blume leaf extract on COX-2 expression of Wi Dr colon cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 251-255页

作者： Agustina Setiawati Handika Immanuel Mery Tri Utami Department of Drug Design and Discovery Faculty of Pharmacy Sanata Dharma University

Objective: To determine the inhibition activity of typhonium flagelliforme Lodd. Blume(T. flagelliforme) leaf extract on cyclooxygenase 2(COX-2) expression of colon cancer ***: T. flagelliforme leaf extract was prepared to macerate in ethyl acetate. In vitro anticancer activity was assayed by MTT method on Wi Dr colon cancer cells. This study applied apoptosis induction assay to investigate the mechanism of cell death using double staining method. COX-2 expression was stained by ***: T. flagelliforme showed anticancer activity and induced apoptosis on Wi Dr cells through inhibition of COX-2 expression with IC5070 mg/m ***: This study showed that T. flagelliforme is a promising chemopreventive agent for colon cancer through COX-2 inhibition.

关键词： typhonium flagelliforme Colon cancer WiDr Cyclooxygenase 2

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