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Two new nonacosanetriols from the pollen of typha angustifolia

Chinese Chemical Letters 2010年第2期21卷 209-212页

作者： Tao, Wei Wei Yang, Nian Yun Duan, Jin Ao Wu, De Kang Shang, Er Xin Qian, Da Wei Tang, Yu Ping Nanjing Univ Chinese Med Jiangsu Key Lab TCM Formuale Res Nanjing 210046 Peoples R China

Chemical investigation of the pollen of typha angustifolia Linn. has led to the isolation of two new nonacosanetriols, 7,8,10-nonacosanetriol ( 1 ) and 7,9,10-nonacosanetriol ( 2 ). Their structures were elucidated by chemical reaction and spectral analysis. Compounds 1 and 2 exhibited weak activity of antiplatelet aggregation in vitro .

关键词： typha angustifolia Nonacosanetriol Antiplatelet aggregation

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Ethanolic extract of Puhuang(Pollen typhae) modulates lipopolysaccharide-induced inflammatory response through inducible nitric oxide synthase/cyclooxygenase-2 signaling in RAW 264.7 macrophages

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Journal of Traditional Chinese Medicine 2021年第6期41卷 836-844页

作者： CHEN Tzufan CHEN Chuntzu HUANG Yuanli BASKARAN Rathinasamy TSAI Jeffrey J.P. HU Rouhmei Department of Biotechnology Asia UniversityTaichung 41354China Taiwan Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354China Taiwan

OBJECTIVE:To evaluate the immune modulatory response of Puhuang(Pollen typhae),ethanolic extract of dried pollens(TP-E)and charcoal activated pollens(CTP-E)were used for their phytochemical evaluation and their modulatory response against lipopolysaccharide(LPS)induced inflammatory activity on RAW264.7 macrophage cells.METHODS:Biochemical assays were carried out to quantify the 1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity,Reducing Power,Ferrous ion chelating ability and total polyphenol content and flavonoids.Non-toxic dose of the extract(TP-E and CTP-E)was chosen based on 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Effect of TP-E and CTP-E on lipopolysaccharides-induced inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)expression was measured by Western blot and quantitative PCR(q RT-PCR).Expression of inflammatory cytokines,such as interleukins(IL-1βand IL-6)and tumor necrosis factorα(TNF-α),was quantified using q RT-PCR.Mitogen-activated protein kinase pathway was analyzed using Western blot.RESULTS:Phytochemical analysis revealed that both TP-E and CTP-E have strong antioxidant activities and high flavonoid and phenolic contents.TP-E and CTP-E effectively inhibit the expression of i NOS and COX-2,thereby inhibiting its downstream proinflammatory regulators,the extracellular signal-related kinase-1/2,that decreases the expression of IL-1β,IL-6 and TNF-α.CONCLUSION:Phytochemical constituents present in typha angustifolia Linn could be used for treating inflammation-related diseases.

关键词： typha angustifolia lipopolysaccharides inflammation NF-kappa B mitogen-activated protein kinases

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