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increased PiT1 and PiT2 Expression in Streptozotocin (STZ)-induced Diabetic Mice Contributes to Uptake of iAs^((V))

Biomedical and Environmental Sciences 2017年第11期30卷 792-801页

作者： YU Sha Li XU Ling Fei WU Jun Xia YAO Chen Juan HU Qiao Yun ZHANG Chun Xue ZHAO Xin Yuan WEi Hai Yan WANG Xiao Ke CHEN Gang Department of Environmental Health School of Public Health Nantong University Department of Molecular Oral Physiology Institute of Biomedical Sciences Tokushima University Graduate School

Objective This study aimed to investigate the susceptibility of mice with streptozotocin（STZ）-induced diabetes mellitus（TiDM） to the uptake of pentavalent inorganic arsenic（iAs^V） and the possible molecular mechanism. Methods TiDM was induced in mice by STZ. TiDM and normal mice were treated with 15.0 mg/kg Na2HAsO4·12H2O by intragastric administration. Then, the concentrations of arsenic in various tissues were measured by atomic fluorescence spectrometry. The gene expression levels of Pit1 and Pit2 were quantified by real-time RT-PCR, and their protein levels were detected by Western blotting in mouse heart, kidney, and liver tissues. Results The concentrations of arsenic in STZ-induced TiDM mouse tissues were higher at 2 h after intragastric administration of Na2HAsO4·12H2O. Compared with the levels in normal mice, PiT1 and PiT2, which play a role in the uptake of iAs^V, were upregulated in the livers and hearts of TiDM mice. PiT1 but not PiT2 was higher in TiDM mouse kidneys. The upregulation of Pit1 and Pit2 expression could be reversed by insulin treatment. Conclusion The increased uptake of iAs^V in TiDM mouse tissues may be associated with increased PiT1 and/or PiT2 expression.

关键词： type i diabetes mellitus Pentavalent inorganic arsenic Uptake Phosphate cotransporters

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Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects

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Neural Regeneration Research 2017年第7期12卷 1111-1118页

作者： Yu-hong Jing Chu-chu Qi Li Yuan Xiang-wen Liu Li-ping Gao Jie Yin institute of Anatomy and Histology & Embryology and Neuroscience School of Basic Medical Sciences Lanzhou University Lanzhou GansuProvince China Key Laboratory of Preclinical Study for New Drugs of Gansu Province Lanzhou University Lanzhou Gansu Province China institute of Biochemistry and Molecular Biology School of Basic Medical Sciences Lanzhou University Lanzhou Gansu Province China

Sensitive smell discrimination is based on structural plasticity of the olfactory bulb,which depends on migration and integration of newborn neurons from the subventricular *** this study,we examined the relationship between neural stem cell status in the subventricular zone and olfactory function in rats with diabetes *** was injected through the femoral vein to induce type 1 diabetes mellitus in Sprague-Dawley *** months after injection,olfactory sensitivity was decreased in diabetic ***,the number of Brd U-positive and Brd U＋/DCX＋double-labeled cells was lower in the subventricular zone of diabetic rats compared with agematched normal *** blot results revealed downregulated expression of insulin receptorβ,phosphorylated glycogen synthase kinase 3β,and β-catenin in the subventricular zone of diabetic ***,these results indicate that diabetes mellitus causes insulin deficiency,which negatively regulates glycogen synthase kinase 3β and enhances β-catenin degradation,with these changes inhibiting neural stem cell ***,these signaling pathways affect proliferation and differentiation of neural stem cells in the subventricular *** of subventricular zone neural stem cells causes a decline in olfactory bulb structural plasticity and impairs olfactory sensitivity in diabetic rats.

关键词： nerve regeneration diabetic encephalopathy adult neural stem cells olfactory function subventricular zone proliferation glycogen synthase kinase 3 beta β-catenin differentiation rats insulin type i diabetes mellitus neural regeneration

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Adverse outcomes in type 1 diabetic pregnant women with proliferative diabetic retinopathy

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international Journal of Ophthalmology(English edition) 2011年第4期4卷 443-446页

作者： C C T Helen i Tajunisah S C Reddy Department of Ophthalmology Faculty of Medicine University of Malaya Department of Ophthalmology Faculty of Medicine International Medical University Clinical School

AiM: To report maternal and fetal adverse outcomes, in spite of appropriate treatment and regular follow up, in diabetic pregnant women with proliferative diabetic retinopathy. METHODS: Case series of four young pregnant diabetics aged between 20 and 25 years with type 1 diabetes mellitus and proliferative diabetic retrinopathy. RESULTS: The maternal adverse outcomes were abortion in one patient, pre-eclampsia and preterm delivery in one patient, and renal failure requiring dialysis in one patient. The fetal adverse outcomes were neonatal death in one case and premature baby in another case. CONCLUSiON: These cases highlight the fact that diabetic pregnant women should be closely followed up by the obstetricians and physicians when they have proliferative retinopathy. The proliferative diabetic retinopathy should be considered as a part of the assessment when counseling a diabetic woman in antenatal check up and also in the follow up visits during pregnancy.

关键词： pregnancy type i diabetes mellitus proliferative diabetic retinopathy vitreous haemorrhage

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