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Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease

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Neural Regeneration Research 2014年第1期9卷 92-100页

作者： Xin Zhou Chun Yang Yufeng Liu Peng Li Huiying Yang Jingxing Dai Rongmei Qu Lin Yuan Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesSouthern Medical University

Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei- mer＇s disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer＇s disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant deg- radative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer＇s disease. Moreover, we describe this mechanism from the view of the two-system theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer＇s disease treatment.

关键词： nerve regeneration lipid rafts amyloid precursor protein autophagy lysosome Alzhei-mer's disease two-system theory amyloid beta peptide autophagosome National Financial MajorProject of China neural regeneration

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Correlations Between Fasciology and Yin-Yang Doctrine

Correlations Between Fasciology and Yin-Yang Doctrine

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2011中国针灸学会年会

作者： Lin Yuan1*,Hui Tao1,Chun Yang1 Mei-chun Yu1,Hui-ying Yang1,Rong-mei Qu1,Xin Zhou1,Yu Bai1,Jing-peng Wu1,Jun Wang2,Dai Jing-xing 1Department of Anatomy,Southern Medical University,Guangzhou,China 2Department of Anatomy,Shenzhen University School of Medicine,Shenzhen,China

Aim To explore the correlations between fasciology and yin-yang *** By three-dimensionally reconstructing connective tissue(fascia) in the trunk and limbs of the human body as well as tracing back to tissue origins in light of biological evolution and developmental biology,*** developed fasciology,which states that the human body can be divided into two systems,the supporting-storing system and the functional *** article elaborates on the respective roles of the two systems and their mutual *** two systems are used to analyze the yin,the yang and their *** The two systems are promoted but also restricted in different *** supporting-storing system is formed by undifferentiated connective tissue and can provide undifferentiated cells and nutrients for various differentiated functional cells of the functional ***,the supporting-storing system could be classified as quiet,similar to *** functional system can continuously maintain the various functional activities of the human ***,the functional system could be classified as active,similar to *** In interpreting the yin-yang doctrine from a fasciological point of view,yin can be compared to the supporting-storing system and yang can be compared to the functional system.

关键词： fasciology two-system theory yin-yang doctrine fascial anatomy

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