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Diabetes and Periodontal Diseases: An Established two-way relationship

Journal of Diabetes Mellitus 2016年第4期6卷 209-229页

作者： Carlos Arana Molina Luna Florencio Ojeda María Sevillano Jiménez Cristóbal Morales Portillo Isabel Serrano Olmedo Tomás Martín Hernández Gerardo Gómez Moreno Department of Endocrinology and Nutrition Virgen Macarena University Hospital Seville Spain Department of Special Care in Dentistry Pharmacological Research in Dentistry Group Faculty of Dentistry University of Granada Granada Spain

Background: Periodontal diseases (PD), including periodontitis, are chronic inflammatory pathologies caused by bacteria in the subgingival biofilm which affect the periodontal tissues. PD is now considered a localized, chronic, oral infection that activates the host immuno-inflammatory responses both locally and systemically, and also constitutes a source of bacteraemia. It is a known fact that periodontal diseases exercise an important influence on the pathogenesis of numerous systemic diseases, including diabetes mellitus (DM). In the mid-nineties, sufficient scientific evidence emerged to confirm an association between DM and periodontitis, which then began to be regarded as the sixth complication of DM. Current scientific evidence points to a two-way relationship between DM and periodontal disease, whereby DM is associated with an increase in the incidence and progression of periodontitis, while periodontal infection is associated with worsening glycemic control in diabetic patients. This two-way relationship points to a need to promote oral health in DM patients, and to implement a joint management protocol between endocrinologist and dentist that aims to create adequate conditions for early diagnosis and the effective treatment of both diseases.

关键词： Diabetes Mellitus Periodontitis Periodontal Medicine two-way relationship

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