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Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities(quotient testosterone/tumour volume)

引用

Asian Journal of Urology 2016年第1期3卷 26-32页

作者： Antonio B.Porcaro Aldo Petrozziello Matteo Brunelli Filippo Migliorini Giovanni Cacciamani Davide De Marchia Nicolo’de Luyk Irene Tamanini Beatrice Caruso Maria A.Cerruto Claudio Ghimenton Walter Artibani Clinica Urologica Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Medicina Interna/Endocrinologia Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Anatomia Patologica Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Medicina di Laboratorio Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly

Objective:To investigate potential associations of preoperative total testosterone(TT)with tumor volume(TV)and grade of prostate cancer(PCa).Methods:Patients who were under medications impacting on the hypothalamic-pituitaryadrenal-testis-prostate axis were *** was measured preoperatively at least 1 month after biopsies and TV was calculated on the removed prostate *** continuous variables included total prostate specific antigen(PSA),percentage of positive cores(Pt)and weight(W)of the removed *** were categorized according to the pathologic Gleason score(pGS)in 3 groups(pGS 6,7 and>7).Invasion of the seminal vesicles was coded as seminal vesicle invasion(SVI).Results:The median levels of TT were significantly and increasingly higher from pGS 6(14.7 nmol/L)to pGS 7(15.0 nmol/L)and pGS>7(18.8 nmol/L).The median values of TV were also detected significantly and increasingly higher from pGS 6(5.6 mL)to pGS 7(8.1 mL)and pGS>7(14.8 mL).The median preoperative levels of PSA were also increasing from pGS 6(5.9 μg/L)to pGS 7(6.2 μg/L)and pGS>7(7.7 μg/L).There was a significant and positive correlation of TV to PSA,TT and *** linear regression analysis showed that TV was significantly and independently predicted by TT,PSA and *** grade PCa(pGS>7)independently associated with TV,TT,Pt and *** median density values of TT relative to TV(quotient TT/TV)significantly decreased from pGS 6(2.6 nmol/L/mL)to pGS 7(1.9 nmol/L/mL)and pGS>7(1.4 nmol/L/mL).The median density values of PSA relative to TV(quotient PSA/TV)also significantly decreased from pGS(1.1 μg/L/mL)to pGS 7(0.7 μg/L/mL)and pGS>7(0.6 μg/L/mL).Conclusion:The investigation shows that TT relates to volume and grade of PCa;moreover,the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour.

关键词： Total testosterone tumour volume Prostate-specific antigen Prostate cancer Pathology Gleason score

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