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OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models

World Journal of Gastroenterology 2008年第30期14卷 4800-4804页

作者： Jun Shi Pin-Kang Wei Shen Zhang Zhi-Feng Qin Jun Li Da-Zhi Sun Yan Xiao Zhi-Hong Yu Hui-Ming Lin Guo-Jing Zheng Xiao-Mei Su Ya-Lin Chen Yan-Fang Liu Ling Xu Department of Traditional Chinese Medicine Shanghai Changzheng Hospital Shanghai 200003 China

AIM： To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique. METHODS： Using OB glue paste technique, orthtopic transplantation models were established by implanting SGC-7901 and NKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed. RESULTS： The success rates of orthotopic transplanration of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%. CONCLUSION： OB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors.

关键词： Gastric tumor tumor transplantation Disease models Animal Nude mice

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A Review of Progress in the Construction and Application of Human-Derived Xenograft Models for Bladder Cancer

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Journal of Biosciences and Medicines 2022年第2期10卷 27-38页

作者： Hao Huang Qi Zhao Chen Gong Xiaowu Pi Feng Guo Jun Li Ying Xiong The First Affiliated Hospital of Yangtze University Jingzhou China

The patient-derived xenografts (PDX) model is an animal model established by transplanting primary tumors or fresh tumor tissues of patient origin directly into immunodeficient mice, which preserves the heterogeneity and survival microenvironment of the primary tumor and is widely used in preclinical and precision medicine research of tumors. This article reviews the construction of the PDX model of human bladder cancer and the progress of the application of the PDX model in bladder cancer.

关键词： Bladder Cancer PDX Model tumor transplantation Preclinical Study

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