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Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： Dong-Qin Xia Yong Zhou Shuang Yang Fang-Fei Li Li-Ya Tian Yan-Hua Li Hai-Yan Xu Cai-Zhi Xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social *** To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer *** study specifically assessed CA19-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(Ptumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.

关键词： Pancreatic ductal adenocarcinoma Carbohydrate antigen 19-9 tumor size Pathologic response Biomarkers

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tumor size discrepancy between endoscopic and pathological evaluations in colorectal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 136-147页

作者： Takeshi Onda Osamu Goto Toshiaki Otsuka Yoshiaki Hayasaka Shun Nakagome Tsugumi Habu Yumiko Ishikawa Kumiko Kirita Eriko Koizumi Hiroto Noda Kazutoshi Higuchi Jun Omori Naohiko Akimoto Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineBunkyo-ku 113-8603TokyoJapan Endoscopy Center Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Hygiene and Public Health Nippon Medical SchoolBunkyoku 113-8603TokyoJapan Center for Medical Education Nippon Medical SchoolBunkyo-ku 113-8603TokyoJapan

BACKGROUND tumor size impacts the technical difficulty and histological curability of colorectal endoscopic submucosal dissection(ESD);however,the preoperative evaluation of tumor size is often different from histological *** influential factors on failure to obtain an accurate tumor size evaluation could help prepare optimal conditions for safer and more reliable *** This was a retrospective study conducted at a single institution.A total of 377 lesions removed by colorectal ESD at our hospital between April 2018 and March 2022 were *** first assessed the difference in size with an absolute per-centage of the scaling ***,we compared the clinicopatho-logical characteristics of the correct scaling group(>-33%and33%),which was further subdivided into the underscaling group(-33%or less of the discrepancy)and overscaling group(33%or more of the discrepancy),*** secondary outcome measures,parameters on size estimation were compared between the underscaling and correct scaling groups,as well as between the overscaling and correct scaling ***,multivariate analysis was performed in terms of the following relevant parameters on size estimation:Pathological size,location,and possible influential factors(Psize was influential on the overscaling(P=0.002).CONCLUSION Lesions indicated for colorectal ESD tended to be underestimate

关键词： Endoscopic submucosal dissection Colorectal tumor tumor size size estimation size discrepancy

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Radiofrequency ablation is an inferior option to liver resection for solitary hepatocellular carcinoma≤5 cm without cirrhosis:A population-based study with stratification by tumor size

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 605-614页

作者： Song-Chen Dong Dou-Sheng Bai Fu-An Wang Sheng-Jie Jin Chi Zhang Bao-Huan Zhou Guo-Qing Jiang Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Hepatobiliary Surgery The First Clinical CollegeDalian Medical UniversityDalian 116000China Department of Interventional Radiology Clinical Medical CollegeYangzhou UniversityYangzhou 225001China

Background:About 10%-20%of all individuals who develop hepatocellular carcinoma(HCC)do not have *** are rarely reported regarding the effectiveness of radiofrequency ablation(RFA)and liver resection(LR)in survival of HCC without cirrhosis and stratification by tumor size≤5 ***:We used the Surveillance,Epidemiology,and End Results(SEER)database and identified 1505 patients with a solitary HCC tumor≤5 cm who underwent RFA or LR during *** were classified into non-cirrhosis and cirrhosis groups and each group was categorized into three subgroups,according to tumor size(≤30 mm,31-40 mm,41-50 mm).Results:In patients without cirrhosis,LR showed better 5-year HCC cancer-specific survival than RFA in all tumor size subgroups(≤30 mm:82.51%vs.56.42%;31-40 mm:71.31%vs.46.83%;41-50 mm:74.7%vs.37.5%;all Ptumor size≤30 mm and 31-40 mm groups,there were no significant survival differences between RFA and LR in multivariate analysis(all P>0.05).However,in those with tumor size 41-50 mm,LR showed significantly better 5-year HCC cancer-specific survival than RFA in both univariate(54.72%vs.23.06%;Ptumor≤5 cm.

关键词： Cirrhosis Liver resection Radiofrequency ablation Hepatocellular carcinoma tumor size

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Impact of age and tumor size on the development of the Kasabach-Merritt phenomenon in patients with kaposiform hemangioendothelioma:a retrospective cohort study

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Precision Clinical Medicine 2023年第2期6卷 81-88页

作者： Jiangyuan Zhou Yuru Lan Tong Qiu Xue Gong Zixin Zhang Chunshui He Qiang Peng Fan Hu Xuepeng Zhang Guoyan Lu Liqing Qiu Feiteng Kong Yongbo Zhang Siyuan Chen Yi Ji Division of Oncology Department of Pediatric SurgeryWest China Hospital of Sichuan UniversityChengdu 610041China Department of Vascular Surgery University Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610032China Department of Pediatric Surgery Chengdu Women and Children’s Central HospitalChengdu 610073China Department of Vascular&Interventional Radiology West China Second University HospitalSichuan UniversityChengdu 610044China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610044China Department of Pediatric Surgery Chengdu Shangjin Nanfu HospitalChengdu 611730China Department of Pediatric Surgery Sichuan Women and Children’s HospitalChengdu 610036China Pediatric Intensive Care Unit Department of Critical Care MedicineWest China Hospital of Sichuan UniversityChengdu 610041China

Introduction The Kasabach–Merritt phenomenon(KMP)is a severe complication of kaposiform hemangioendothelioma(KHE).The risk factors for KMP need further *** The medical records of patients with KHE were *** and multivariate logistic regression models were used for the risk factors for KMP,and the area under the receiver operator characteristic(ROC)curve was used to assess the predictive power of risk *** A total of 338 patients with KHE were *** incidence of KMP was 45.9%.Age of onset(Psize(Psize of 5.35 cm,we found significant differences in tumor morphology,age of onset,treatments,and hematological *** an onset age of 4.75 months as a cutoff,we found significant differences in tumor morphology,lesion size,hematological parameters,and *** For KHE patients with an onset age5.35 cm,clinicians should be wary of the occurrence of *** management is recommended to improve the prognosis.

关键词： kaposiform hemangioendothelioma Kasabach-Merritt phenomenon age of onset tumor size cutoff values

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Cone beam computed tomography-guided differences among registration methods for lung cancer and the effects of tumor position,treatment model,and tumor size on positioning errors

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Oncology and Translational Medicine 2021年第5期7卷 203-208页

作者： Jiayu Du Jie Tang Qian Zhang Xiaojie Ma Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Radiation Oncology North Sichuan Medical CollegeNanchong 637000China Department of Clinical Medicine North Sichuan Medical CollegeNanchong 637000China

Objective To explore the differences in three different registration methods of cone beam computed tomography(CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects of tumor location,treatment mode,and tumor size on *** This retrospective analysis included 80 lung cancer patients undergoing radiotherapy in our hospital from November 2017 to October 2019 and compared automatic bone registration,automatic grayscale(t+r)registration,and automatic grayscale(t)positioning error on the X-,Y-,and Z-axes under three types of registration *** patients were also grouped according to tumor position,treatment mode,and tumor size to compare positioning *** On the X-,Y-,and Z-axes,automatic grayscale(t+r)and automatic grayscale(t)registration showed a better *** of the different treatment modes showed differences in the three registration methods;however,these were not statistically *** according to tumor sizes showed significant differences between the three registration methods(Ptumor positions showed differences in the X-and Y-axes that were not significant(P>0.05),while the autopsy registration in the Z-axis showed the largest difference in the mediastinal and hilar lymph nodes(Ptumors in the upper and lower lungs measuringtumors located in the mediastinal hilar site measuring<3 cm and in the upper and lower lungs≥3 cm.

关键词： lung cancer IMRT positioning error registration method CBCT different tumor locations different treatment modes tumor size

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Are tumor size and depth based on CT or MR image prognostic factors in patients with tongue squamous cell carcinoma after surgical resection?

Are tumor size and depth based on CT or MR image prognostic ...

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中华口腔医学会第九次全科口腔医学学术会议

作者： Chongjin Feng Jiameng Liu Shan Chen Yang Chen Ningbo Geng

Objective The purpose of this retrospective study was to explore the relationship between tumor size and depth of invasion through CT or MRI images and outcomes in patients with tongue squamous cell carcinoma. Meanwhile this study was also to propose the optimum cut-off point for tumor size and depth of invasion in assessing prognosis in patients with TSCC. Materials and Methods Reviewing the Clinical Data of 233 Tongue Cancer Patients from October 1999 to May 2013. tumor size and depth of invasion, originally presented as continuous variable, were divided into lower group and larger group through an optimal cutoff point by ROC curve. The relationship between tumor size and depth and other clinicopathological parameters were explored by Chi-square test. Kaplan-Meier method was used to estimate the survival of TSCC patients, and the log-rank test was applied to investigate the survival difference of TSCC. Finally, univariate and multivariate analysis were used to find the significant prognostic factor for TSCC and ptumor size and depth of invasion was determined, which were 2.5 cm and 1.5cm respectively. Base on that, patients were divided into two groups(patients with tumors size larger than 2.5 cm and smaller than 2.5 cm, and patients with tumors larger than 1.5 cm and smaller than 1.5 cm in depth). Our study shows that tumor size was related significantly to depth of invasion(Ptumor size(Ptumor size smaller than 2.5cm than those with a tumor size larger than 2.5 cm(59.0% versus 10.4%, P = 0.000) and also in patients with a tumor depth of invasion smaller than 1.5cm when compared with those with a depth larger than 1

关键词： Tongue cancer prognostic factor survival tumor size depth of invasion

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Large Medial Sphenoid Wing Meningiomas: long-term outcome and correlation with tumor size after microsurgical in 127 consecutive cases

Large Medial Sphenoid Wing Meningiomas: long-term outcome an...

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2011中华医学会神经外科学学术会议

作者： Dingyang Liu1 Xianrui Yuan1 Qing Liu1 Xinjun Jiang1 Weixi Jiang1 Zefeng Peng1 Xiping Ding1 Duanwu Luo1 1.Department of Neurosurgery, Xiangya Hospital, Central South University, 8 7 Xiangya Road, Changsha, Hunan 4 1 0008 , China

Objective We present the long-term outcomes as well as their correlation with tumor size in 127 consecutive patients harboring large medial sphenoid wing meningiomas (MSWM) after microsurgical *** The retrospective an... 详细信息

关键词： medial sphenoid wing meningiomas tumor size tumor recurrence functional outcome.

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Identification of predictive factors for post-transarterial chemoembolization liver failure in hepatocellular carcinoma patients: A retrospective study

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World Journal of Clinical Cases 2022年第24期10卷 8535-8546页

作者： Min Yuan Tian-You Chen Xiao-Rong Chen Yun-Fei Lu Jia Shi Wen-Si Zhang Chen Ye Bo-Zong Tang Zong-Guo Yang Department of Interventional Medicine Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of Integrative Medicine Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of Internal Medicine of Traditional Chinese Medicine Shanghai East HospitalTongji University School of MedicineShanghai 201200China

BACKGROUND Post-transarterial chemoembolization(TACE)liver failure occurs frequently in hepatocellular carcinoma(HCC)*** identification of predictors for post-TACE liver failure is of great importance for clinical decision-making in this *** To investigate the occurrence rate and predictive factors of post-TACE liver failure in this retrospective study to provide clues for decision-making regarding TACE procedures in HCC *** The clinical records of HCC patients treated with TACE therapy were *** clinical characteristics and laboratory parameters of these patients were *** models were used to identify candidates to predict post-TACE liver *** A total of 199 HCC patients were enrolled in this study,and 70 patients(35.2%)developed post-TACE liver *** and multivariate logistic models indicated that microspheres plus gelatin embolization and main tumor size>5 cm were risk predictors for post-TACE liver failure[odds ratio(OR):4.4,95%confidence interval(CI):1.2-16.3,P=0.027;OR:2.3,95%CI:1.05-5.3,P=0.039,respectively].Conversely,HCC patients who underwent tumor resection surgery before the TACE procedure had a lower risk for post-TACE liver failure(OR:0.4,95%CI:0.2-0.95,P=0.039).CONCLUSION Microspheres plus gelatin embolization and main tumor size might be risk factors for post-TACE liver failure in HCC patients,while prior tumor resection could be a favorable factor reducing the risk of post-TACE liver failure.

关键词： Transarterial chemoembolization Liver failure Hepatocellular carcinoma Embolization tumor size

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Is lymphatic invasion of microrectal neuroendocrine tumors an incidental event?:A case report

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World Journal of Clinical Cases 2023年第4期11卷 859-865页

作者： Jing-Xue Ran Liang-Bi Xu Wan-Wei Chen Hao-Yi Yang Yan Weng Yong-Mei Peng Clinical Medical School Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Endoscopy Center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND A rectal neuroendocrine tumor(rNET)is a malignant tumor originating from neuroendocrine ***,tumor size is the primary basis for assessing tumor *** SUMMARY This article reports the case of a 46-year-old male patient who underwent a colonoscopy that found a 3 mm rectal polypoid *** pathological examination of a sample collected with biopsy forceps revealed a neuroendocrine *** endoscopic submucosal dissection rescue therapy was *** presence of lymphatic vessels indicated that the tumor had infiltrated the negative resection *** lesion was located in the distal rectum near the anal ***,to ensure the patient’s quality of life,follow-up observation was conducted after full communication with the *** tumor recurrence or distant metastasis has been found during the 13-mo follow-up after *** Despite the presence of lymphatic invasion and extremely small diameter rNETs in our case,this phenomenon may not imply a higher risk of distant lymph node and organ metastasis.

关键词： Rectal neuroendocrine tumor tumor size Lymphatic invasion Case report

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Goldilocks principle of minimally invasive surgery for gastric subepithelial tumors

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1629-1640页

作者： Wei-Jung Chang Lien-Cheng Tsao Hsu-Heng Yen Chia-Wei Yang Hung-Chi Chang Chew-Teng Kor Szu-Chia Wu Kuo-Hua Lin Department of General Surgery Changhua Christian HospitalChanghua 50006TaiwanChina Department of Gastroenterology Changhua Christian HospitalChanghua 50006TaiwanChina General Education Center Chienkuo Technology UniversityChanghua 50006TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Big Data Center Changhua Christian HospitalChanghua 50006TaiwanChina Graduate Institute of Statistics and Information Science National Changhua University of EducationChanghua 50007TaiwanChina Transplant Medicine&Surgery Research Center Changhua Christian HospitalChanghua 50006TaiwanChina

BACKGROUND Minimally invasive surgery had been tailored to individual cases of gastric subepithelial tumors(SETs)after comparing the clinical outcomes of endoscopic resection(ER),laparoscopic resection(LR),and hybrid *** To study the use of Goldilocks principle to determine the best form of minimally invasive surgery for gastric *** In this retrospective study,194 patients of gastric SETs with high probability of surgical intervention were *** patients underwent tumor resection in the operating theater between January 2013 and December *** patients were divided into two groups,ER or LR,according to the tumor characteristics and the initial intent of *** patients in the ER group required further backup laparoscopic surgery after an incomplete *** patients who had converted open surgery were excluded.A logistic regression model was used to assess the associations between patient characteristics and the likelihood of a treatment *** area under the curve was used to assess the discriminative ability of tumor size and Youden’s index to determine the optimal cut-off tumor *** One-hundred ninety-four patients(100 in the ER group and 94 in the LR group)underwent tumor resection in the operating *** the ER group,27 patients required backup laparoscopic surgery after an incomplete *** patients in the ER group had small tumor sizes and shorter procedure durations while the patients in the LR group had large tumor sizes,exophytic growth,malignancy,and tumors that were more often located in the middle or lower third of the *** groups had similar durations of hospital stays and a similar rate of major postoperative *** patients in the ER group who underwent backup surgery required longer procedures(56.4 min)and prolonged stays(2 d)compared to the patients in the LR group without the increased rate of major postoperative *** optimal cut-off point for the tumor size for l

关键词： Gastric subepithelial tumors Endoscopic resection Laparoscopic resection tumor size

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