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Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection

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Frontiers of Chemical Science and Engineering 2022年第4期16卷 536-545页

作者： Sunhui Chen Qiujun Qiu Dongdong Wang Dejun She Bo Yin Meihong Chai Huining He Dong Nyoung Heo Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Department of Radiology Huashan HospitalFudan UniversityShanghai 200040China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Dental Materials School of DentistryKyung Hee UniversitySeoul 02447Republic of Korea

Many scientific efforts have been made to penetrate the blood-brain barrier and target glioblastoma cells,but the outcomes have been *** attention should be given to local inhibition of recurrence after glioblastoma resection to meet real medical needs.A biodegradable wafer containing the chemotherapeutics carmustine(1,3-bis(2-chloroethyl)-1-nitrosourea,BCNU)was the only local drug delivery system approved for clinical glioblastoma treatment,but with a prolonged survival time of only two months and frequent side *** this study,to improve the sustained release and prolonged therapeutic effect of drugs for inhibiting tumor recurrence after tumor resection,both free BCNU and BCNU-poly(lactic-co-glycolic acid)(the ratio of lactic acid groups to glycolic acid groups is 75/25)nanoparticles were simultaneously loaded into natural extracellular matrix hydrogel from pigskin to prepare BCNU *** hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removal in a fully characterized resection rat *** drugs were released instantly to kill the residual tumor cells,while drugs in nanoparticles were continuously released to achieve a continuous and effective inhibition of the residual tumor cells for 30 *** combined actions effectively restricted tumor growth in ***,this strategy of local drug implantation and delivery may provide a reliable method to inhibit the recurrence of glioblastoma after tumor resection in vivo.

关键词： BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel

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Adaptability of bipedicled scalp advancement flap for coverage of huge scalp defects after tumor resection

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 16-21页

作者： Waleed Aldabaany Department of Plastic Surgery Faculty of MedicineFayoum UniversityFayoumEgypt

Background:Several reconstructive techniques have been used to reconstruct scalp *** researchers have studied the utilization of bipedicled scalp advancement flaps for scalp defect *** this study,we will assess the adaptability of a bipedicled scalp advancement flap for coverage of huge scalp defects after tumor ***:This study was performed at the Plastic Surgery Department,Fayoum University Hospital,on 20 patients with huge scalp tumors treated by adequate excision and reconstructed using a bipedicled scalp advancement flap from December 2021 to July ***:The study was conducted on 20 patients:16(80%)were men and 4(20%)were women presenting with large scalp *** mean age was 57.4 years(33-68 years).The sites of the tumors were 10(50%)occipital,6(30%)parietal,and 4(20%)*** major complications occurred postoperatively,and the bipedicled flaps survived well in all cases,with no ***:Huge scalp defects after tumor resection can be safely reconstructed with a large versatile bipedicled advancement scalp flap,either transversely or longitudinally oriented,with favorable functional results and accepted aesthetic results,apart from the alopecic area over the grafted donor site,which can be treated by tissue expansion if desired later.

关键词： Bipedicled advancement flap Huge scalp defects tumor resection

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Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition

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Nano Research 2023年第12期16卷 13226-13249页

作者： Fuming Liang Qing You Hongjiang Ye Wenqiao Fu Xiaopeng Ma Jiahe Tan Yinrui Ma Chen Wang Yanlian Yang Zhaohui He Ling Zhu CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China The First Affiliated Hospital University of Science and Technology of China Anhui Provincial HospitalHefei 230000China

Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging due to the lack of high-resolution,easy-to-operate,and fast visualization *** the other hand,tumor recurrence and metastasis after surgery greatly reduce the survival rate of *** tumor recurrence during surgery is a future direction of tumor *** with external condition responsiveness(light,ultrasound,and magnetic field)can accurately assist intraoperative detection and surgical resection due to their functions such as tumor cell targeting,fluorescence imaging,and real time monitoring,providing a more accurate,shorter duration,and visualization method of surgical ***,nanomaterials are versatile and can easily be tailored for application in different *** filled or systemically circulating nanomaterials with slow drug release and residual tumor cell-targeting ability have promising applications in inhibiting tumor ***,we review surgical navigation and postoperative recurrence interventional nanomaterials and their landscape in guiding tumor *** summarize the classification and characteristics of these nanomaterials and discuss their application in the surgical navigation and recurrence inhibition of different *** also provide an outlook on the challenges and future development of nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition.

关键词： nanomaterials surgical navigation tumor resection tumor recurrence inhibition

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Evaluating the use of three-dimensional reconstruction visualization technology for precise laparoscopic resection in gastroesophageal junction cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1311-1319页

作者： Dan Guo Xiao-Yan Zhu Shuai Han Yu-Shu Liu Da-Peng Cui Department of Hepatobiliary Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Laparoscopic gastrectomy for esophagogastric junction(EGJ)carcinoma enables the removal of the carcinoma at the junction between the stomach and esophagus while preserving the gastric function,thereby providing patients with better treatment outcomes and quality of ***,this surgical technique also presents some challenges and ***,three-dimensional reconstruction visualization technology(3D RVT)has been introduced into the procedure,providing doctors with more comprehensive and intuitive anatomical information that helps with surgical planning,navigation,and outcome *** To discuss the application and advantages of 3D RVT in precise laparoscopic resection of EGJ *** Data were obtained from the electronic or paper-based medical records at The First Affiliated Hospital of Hebei North University from January 2020 to June 2022.A total of 120 patients diagnosed with EGJ carcinoma were included in the *** these,68 underwent laparoscopic resection after computed tomography(CT)-enhanced scanning and were categorized into the 2D group,whereas 52 underwent laparoscopic resection after CT-enhanced scanning and 3D RVT and were categorized into the 3D *** study had two outcome measures:the deviation between tumor-related factors(such as maximum tumor diameter and infiltration length)in 3D RVT and clinical reality,and surgical outcome indicators(such as operative time,intraoperative blood loss,number of lymph node dissections,R0 resection rate,postoperative hospital stay,postoperative gas discharge time,drainage tube removal time,and related complications)between the 2D and 3D *** Among patients included in the 3D group,27 had a maximum tumor diameter of less than 3 cm,whereas 25 had a diameter of 3 cm or *** actual surgical observations,24 had a diameter of less than 3 cm,whereas 28 had a diameter of 3 cm or *** findings were consistent between the two methods(χ^(2)=0.346,P=0.556),w

关键词： Gastroesophageal junction cancer Endoscopy tumor resection Three-dimensional reconstruction visualization Two-dimensional imaging computed tomography

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Primary Malignant Giant Cell tumor of Bone:A Case Report

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Proceedings of Anticancer Research 2021年第4期5卷 23-26页

作者： Guojun Zhou Sen Li Zhibin Li Qingpeng Deng Peng Wang Xiaowen Sang The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine Xianyang 712046Shaanxi ProvinceChina Joint Ward Orthopedics HospitalAffiliated Hospital of Shaanxi University of Traditional Chinese MedicineXianyang 712000Shaanxi ProvinceChina

Primary malignant giant cell tumor of bone is clinically rare,lack of specificity,and often ***,related literature about this tumor remains *** case of primary malignant giant cell tumor of bone was diagnosed and treated in our hospital,and the treatment effect was *** was no recurrence or metastasis in 2 years of *** report is as follows.

关键词： Giant cell tumor of bone Primary Malignant Distal femur tumor resection Hinge knee replacement

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