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Rasburicase in treating tumor lysis syndrome:An umbrella review

Cancer Pathogenesis and Therapy 2023年第4期1卷 262-271页

作者： Kamran Mahfooz Haris Sohail Ani Gvajaia Uroosa Arif Daisy Grewal Monica Reddy Muppidi Vanya Vohra Aamir Tarique Advait Vasavada Department of Internal Medicine Lincoln Medical CenterCommunity HospitalNew York10451USA Department of Internal Medicine St.Georges UniversitySt.GeorgesGrenada Department of Pediatrics St Barnabas HospitalBronxNY10457USA Department of Medicine ESIC Medical CollegeFaridabad121001India Department of Medicine MP Shah Medical CollegeJamnagar361008India

tumor lysis syndrome(TLS)remains a debilitating cause of hospitalization and death in patients with cancer and is a significant challenge for healthcare providers despite advancements in its *** umbrella review analyzed the results of meta-analyses on the use of rasburicase in the treatment of patients with cancer.A literature search was performed of five databases(PubMed,Google Scholar,Cochrane Library,Scopus,Global Index Medicus,and ScienceDirect)for articles with full texts available online.A measurement tool to assess systematic reviews 2(AMSTAR 2)was used to assess the quality of the included studies,and Review Manager software was used to conduct all statistical *** systematic search identified eight relevant meta-analyses,with primary analyses including outcome data that analyzed mortality,renal failure,and comparisons with *** pooled data showed that rasburicase effectively reduced TLS development and serum uric acid levels in children and adults with *** outcomes did not differ significantly compared with those of *** trials should focus on the cost-effectiveness of rasburicase compared to that of allopurinol while including high-,intermediate-,and low-risk *** is safe and effective for managing patients with ***,recent large-scale meta-analyses have reported conflicting *** meta-analyses were graded as low to critically low as per AMSTAR *** analysis revealed that the benefit of rasburicase did not differ significantly from that of allopurinol,which has higher cost-effectiveness and fewer side effects.

关键词： tumor lysis Hematologic urgency Rasburicase Drug therapy

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Oncolytic virus therapy in cancer: A current review

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World Journal of Virology 2021年第5期10卷 229-255页

作者： Jonathan Santos Apolonio Vinicius Lima de Souza Goncalves Maria Luisa Cordeiro Santos Marcel Silva Luz Joao Victor Silva Souza Samuel Luca Rocha Pinheiro Wedja Rafaela de Souza Matheus Sande Loureiro Fabricio Freire de Melo Universidade Federal da Bahia Instituto Multidisciplinar em SaudeVitoria da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitoria da ConquistaVitoria da Conquista 45083-900BahiaBrazil

In view of the advancement in the understanding about the most diverse types of cancer and consequently a relentless search for a cure and increased survival rates of cancer patients,finding a therapy that is able to combat the mechanism of aggression of this disease is extremely ***,oncolytic viruses(OVs)have demonstrated great benefits in the treatment of cancer because it mediates antitumor effects in several *** can be used to infect cancer cells,especially over normal cells,to present tumor-associated antigens,to activate“danger signals”that generate a less immune-tolerant tumor microenvironment,and to serve transduction vehicles for expression of inflammatory and immunomodulatory *** success of therapies using OVs was initially demonstrated by the use of the genetically modified herpes virus,talimogene laherparepvec,for the treatment of *** this time,several OVs are being studied as a potential treatment for cancer in clinical ***,it is necessary to be aware of the safety and possible adverse effects of this therapy;after all,an effective treatment for cancer should promote regression,attack the tumor,and in the meantime induce minimal systemic *** this manuscript,we will present a current review of the mechanism of action of OVs,main clinical uses,updates,and future perspectives on this treatment.

关键词： Oncolytic viruses Antitumor response tumor lysis tumor cells Mechanism Therapy

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