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Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4092-4103页

作者： Zhuo-Ran Wang Cun-Zhen Zhang Zhan Ding Yi-Zhuo Li Jian-Hua Yin Nan Li Department of Hepatic Surgery I(Ward I)Shanghai Eastern Hepatobiliary Surgery Hospital Navy Medical UniversityShanghai 200433China Key Laboratory of Biological Defense Ministry of EducationNavy Medical UniversityShanghai 200433China Shanghai Key Laboratory of Medical Bioprotection Navy Medical UniversityShanghai 200433China Department of Epidemiology Faculty of Navy MedicineNavy Medical UniversityShanghai 200433China Department of Oncology 905 Hospital of People’s Liberation Army NavyShanghai 200050China Department of Hepatobiliary Surgery The Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ***-associated immune cells are critical for tumor development and *** main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for *** To establish 1-year and 3-year prognostic models for ICC after surgical *** Immunohistochemical staining was performed for CD4,CD8,CD20,pan-cytokeratin(CK),and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative *** of variables was based on regression diagnostic procedures and goodness-of-fit tests(PH assumption).Clinical parameters and pathological diagnoses,combined with the distribution of immune cells in tumors and paired adjacent tissues,were utilized to establish 1-and 3-year prognostic *** This is an important application of immune cells in the tumor ***4,CD8,CD20,and CK were included in the establishment of our prognostic model by stepwise selection,whereas CD68 was not significantly associated with the prognosis of *** integrating clinical data associated with ICC,distinct prognostic models were derived for 1-and 3-year survival outcomes using variable *** 1-year prediction model yielded a C-index of 0.7695%confidence interval(95%CI):0.65-0.87 and the 3-year prediction model produced a C-index of 0.69(95%CI:0.65-0.73).Internal validation yielded a C-index of 0.761(95%CI:0.669-0.853)for the 1-year model and 0.693(95%CI:0.642-0.744)for the 3-year *** We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection,which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment an

关键词： Intrahepatic cholangiocarcinoma tumor immune cells Biomarkers Prognosis Prediction models

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