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RNA-sequencing-based Gene Expression Profile Revealing Breast tumor development Induced by Exposure of Bisphenol S

Chemical Research in Chinese Universities 2023年第3期39卷 441-448页

作者： ZHOU Peng XIAO Yu ZHOU Xin LIU Jianjun ZHAO Chao Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Ultrasound The First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen Second People’s HospitalShenzhen518035P.R.China Department of Breast and Thyroid Surgery Shenzhen Second People’s Hospital/The First Hospital Affiliated to Shenzhen UniversityShenzhen518035P.R.China Shenzhen Key Laboratory of Modern Toxicology Shenzhen Medical Key Discipline of Health Toxicology(2020—2024)Shenzhen Center for Disease Control and PreventionShenzhen518055P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha410013P.R.China

Aberrant biological information occurs naturally at exposure to bisphenol A or its alternatives,which was associated with the occurrence and development of breast cancer.However,the potential molecular variation in gene expression during the breast tumor development is still unclear.Herein,high throughput RNA sequencing(RNA-Seq)and bioinformatics analysis were used to investigate the variation of tumor-mRNA profile exposed with BPS5(5µg/kg bw/day)or BPS50(50µg/kg bw/day)in tumor development-associated MMTV-PyMT transgenic mouse model.Meanwhile,we analyzed the dose-effects of bisphenol S(BPS)and BPS-induced tumor development on the gene level exhaustively.In dose-effect aspects of BPS,the increased concentration of BPS significantly changed the numbers and enrichment pathway of differentially expressed genes(DEGs),especially the enrichment pathways involved in up-regulated genes including ribosome,peroxisome proliferators-activated receptor(PPAR)signaling pathway and progesterone-mediated oocyte maturation pathway.In effects of BPS exposure to tumor development,expression of IgκC,Zfp385b,Cldn10,Pgr and Snord14d has changed significantly throughout the tumor development.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)results obtained from BPS-induced tumor development showed that the functional classifications were intensively altered with an extension of time in high-dose BPS groups.The acquired DEGs and pathway information could help with the accurate exploration of molecular mechanisms of tumor development,screening of molecular targets of breast cancer,and toxicological evaluation of environmental pollutants.

关键词： Bisphenol S RNA-sequencing Breast cancer tumor development

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Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development

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Science China(Life Sciences) 2017年第10期60卷 1133-1141页

作者： Qiaoni Shi Ye-Guang Chen State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China

Transforming growth factor-β(TGF-β) signaling regulates cell proliferation, differentiation, migration and death, and plays a critical role in embryogenesis and tissue homeostasis. Its deregulation results in various diseases including tumor formation.Receptor tyrosine kinases(RTKs), such as epidermal growth factor receptor(EGFR), fibroblast growth factor receptor(FGFR),vascular endothelial growth factor receptor(VEGFR) and platelet-derived growth factor receptor(PDGFR), also play key roles in the development and progression of many types of tumors. It has been realized that TGF-β signaling and RTK pathways interact with each other and their interplay is important for cancer development. They are mutually regulated and cooperatively modulate cell survival and migration, epithelial-mesenchymal transition, and tumor microenvironment to accelerate tumorigenesis and tumor metastasis. RTKs can modulate Smad-dependent transcription or cooperate with TGF-β to potentiate its oncogenic activity,while TGF-β signaling can in turn control RTK signaling by regulating their activities or expression. This review summarizes current understandings of the interplay between TGF-β signaling and RTKs and its influence on tumor development.

关键词： TGF-β receptor tyrosine kinase crosstalk tumor development

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TP53BP2:Roles in suppressing tumorigenesis and therapeutic opportunities

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Genes & Diseases 2023年第5期10卷 1982-1993页

作者： Yunfei Huo Ke Cao Buxin Kou Mengyin Chai Shuangshuang Dou Dexi Chen Ying Shi Xiaoni Liu Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Malignant tumor is still a major problem worldwide.During tumorigenesis or tumor development,tumor suppressor p53-binding protein 2(TP53BP2),also known as apoptosis stimulating protein 2 of p53(ASPP2),plays a critical role in p53 dependent and independent manner.Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients.TP53BP2 can interact with p53,NF-κB p65,Bcl-2,HCV core protein,PP1,YAP,CagA,RAS,PAR3,and other proteins to regulate cell function.Moreover,TP53BP2 can also regulate the proliferation,apoptosis,autophagy,migration,EMT and drug resistance of tumor cells through downstream signaling pathways,such as NF-κB,RAS/MAPK,mevalonate,TGF-β1,PI3K/AKT,aPKC-ι/GLI1 and autophagy pathways.As a potential therapeutic target,TP53BP2 has been attracted more attention.We review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2,which may provide more deep insight and strategies for tumor treatment.

关键词： Binding proteins Signaling pathways TP53 TP53BP2 tumorigenesis tumor development

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Role of tumor-associated macrophages in common digestive system malignant tumors

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 596-616页

作者： Yue Shen Jia-Xi Chen Ming Li Ze Xiang Jian Wu Yi-Jin Wang Department of Dermatology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Pathology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina Department of Clinical Laboratory Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina School of Medicine Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina

Many digestive system malignant tumors are characterized by high incidence and mortality rate.Increasing evidence has revealed that the tumor microenvironment(TME)is involved in cancer initiation and tumor progression.tumor-associated macrophages(TAMs)are a predominant constituent of the TME,and participate in the regulation of various biological behaviors and influence the prognosis of digestive system cancer.TAMs can be mainly classified into the antitumor M1 phenotype and protumor M2 phenotype.The latter especially are crucial drivers of tumor invasion,growth,angiogenesis,metastasis,immunosuppression,and resistance to therapy.TAMs are of importance in the occurrence,development,diagnosis,prognosis,and treatment of common digestive system malignant tumors.In this review,we summarize the role of TAMs in common digestive system malignant tumors,including esophageal,gastric,colorectal,pancreatic and liver cancers.How TAMs promote the development of tumors,and how they act as potential therapeutic targets and their clinical applications are also described.

关键词： tumor-associated macrophages Digestive system malignant tumors tumor development Therapeutic targets Clinical applications

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Metal ions as effectual tools for cancer with traditional Chinese medicine

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Acupuncture and Herbal Medicine 2023年第4期3卷 296-308页

作者： Lei Wang Yingqiu Xie Sandugash Myrzagali Weiling Pu Erwei Liu State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Biology School of Sciences and HumanitiesNazarbayev UniversityAstanaKazakhstan

Malignant tumor has become a major threat affecting human health,and is one of the main causes of human death.Recent studies have shown that many traditional Chinese medicines(TCM)have good anti-tumor activity,which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity.However,the efficacy of TCM alone for the treatment of tumors is limited.Metal ions are essential substances for maintaining normal physiological activities.This article summarized the multiple mechanisms in which metal ions are involved in the prevention and treatment of tumors in TCM.

关键词： Metal ions Traditional Chinese medicine Treatment modalities tumor development

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Neuro-oncogenesis and the adult human sub-ventricular zone in high grade glioma

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 20-26页

作者： Sara G.M.Piccirillo John van Geest Centre for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeCB20PYUK

The last fifteen years have seen the application of the cancer stem cell hypothesis to tumors of the central nervous system,in particular to high grade glioma(HGG),the most aggressive and common brain cancer in adults.Seminal studies have shown that cancer stem cells(alternatively named tumor-initiating cells)are capable of self-renew and multipotency,similar to their normal counterpart.More importantly they give rise to tumors that closely mimic the phenotype and genotype of human HGG.The identification of neurogenic niches in adult rodent and human brain has further reinforced the hypothesis that HGG might derive from the malignant transformation occurring in these areas,especially in the sub-ventricular zone(SVZ),the largest and most well characterised stem cell niche.Following from evidence of animal model studies supporting this hypothesis,recently we investigated the role of the SVZ in neuro-oncogenesis using tissue material derived from HGG patients.We also described response to conventional chemo-therapies of cancer stem cells isolated from the SVZ and the tumor mass(T)of the same patients and reconstructed tumor evolution.In this review,such findings will be discussed in the context of the current literature on the biology of the SVZ in the normal and disease brain.

关键词： High grade glioma tumor-initiating cells sub-ventricular zone tumor development

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Tim-3 blockade in tumor-infiltrating NK inhibits tumor growth

Tim-3 blockade in tumor-infiltrating NK inhibits tumor growt...

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第十届全国免疫学学术大会

作者： Yong Xu Hualin Zhang Xiaohong Liang Lifen Gao Chunhong Ma Department of Immunology Shandong University School of Medicine

Background:Natural killer(NK)cell plays critical roles in anti-tumor immunity.T cell immunoglobulin and mucin domain-3(Tim-3)is a well-known immune mediator,which is involved in the regulation of NK function.Objective... 详细信息

关键词： Tim-3 HCC NK cells tumor development

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