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Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy

Nano-Micro Letters 2022年第9期14卷 95-131页

作者： Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102People’s Republic of China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361102

As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target *** importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its *** regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell ***,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer ***,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT *** paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly *** review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel *** and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.

关键词： Calcium-based nanomaterials Cancer therapy Calcium signaling tumor calcification Theranostics

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