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Glioma stem cells and the occurrence of tumor blood vessels

Discussion of Clinical Cases 2015年第2期2卷 12-22页

作者： Yude Zhu Qiang Huang The Third Affiliated Hospital of Inner Mongolia Medical University HohhotChina

Epithelial glioma is the most common brain cancer,accounting for 35.26%-60.69%of intracranial tumors with an average of 44.69%,and it remains the greatest challenge in the field of *** median survival time of patients with advanced glioma is only 12 to 18 months due to the characteristics of high aggression,and the therapeutic effect was poor though surgery,chemotherapy,and targeted drug therapy being *** of the presence of heterogeneity and the differentiation disorder,only a small number of glioma cells are the source of tumor growth and metastasis,which are highly resistant to traditional *** are deemed as the“seed”tumor cells as they could get rid of the effect of the treatment and reconstruct the organization of *** are also termed as brain tumor stem cell(BTSC)or glioma stem cells(GSCs)since neural stem cells share similar features with *** data reveal that they are directly related with invasion,angiogenesis,tolerance,chemotherapy,recurrence of *** on the research result by the team,the paper elaborates the characteristics of GSCs and the relationship with the tumor angiogenesis.

关键词： Glioma stem cells tumor blood vessels

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-Jin Lu Rui-Sui Huang Qiong Chen Li-Feng Huang Jian-Ning Huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule tumor blood vessels

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Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 450-477页

作者： Piao Zheng Zhen Huang Dong-Chang Tong Qing Zhou Sha Tian Bo-Wei Chen Di-Min Ning Yin-Mei Guo Wen-Hao Zhu Yan Long Wei Xiao Zhe Deng Yi-Chen Lei Xue-Fei Tian College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Integrated Traditional Chinese and Western Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Institute of Integrative Medicine Department of Integrated Traditional Chinese and Western MedicineXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang *** compounds show anticancer activity in other biological ***,whether frankincense and/or myrrh can inhibit the occurrence of hepatocellular carcinoma(HCC)is unknown,and the potential molecular mechanism(s)has not yet been *** To predict and determine latent anti-HCC therapeutic targets and molecular mechanisms of frankincense and myrrh in *** In the present study,which was based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://***/***),Universal Protein database(http://***),GeneCards:The Human Gene Database(http://***/)and Comparative Toxicogenomics Database(http://***/),the efficacy of and mechanism by which frankincense and myrrh act as anti-HCC compounds were *** core prediction targets were screened by molecular *** vivo,SMMC-7721 human liver cancer cells were transplanted as xenografts into nude mice to establish a subcutaneous tumor model,and two doses of frankincense plus myrrh or one dose of an EGFR inhibitor was administered to these mice continuously for 14 *** tumors were collected and evaluated:the tumor volume and growth rate were gauged to evaluate tumor growth;hematoxylineosin staining was performed to estimate histopathological changes;immunofluorescence(IF)was performed to detect the expression of CD31,α-SMA and collagen IV;transmission electron microscopy(TEM)was conducted to observe the morphological structure of vascular cells;enzyme-linked immunosorbent assay(ELISA)was performed to measure the levels of secreted HIF-1αand TNF-α;reverse transcription-polymerase chain reaction(RT-qPCR)was performed to measure the mRNA expression of HIF-1α,TNF-α,VEGF and MMP-9;and Western blot(WB)was performed to determine the levels of proteins expressed in the EGFR-mediated PI3K/Akt and

关键词： Hepatocellular carcinoma Frankincense Myrrh Network pharmacology tumor blood vessels Multiple signaling pathways

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