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Uterus movement and cervical tumor regression during external beam radiotherapy for cervical cancer accessed by online cone beam computed tomography

Uterus movement and cervical tumor regression during externa...

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首届浙赣两省肿瘤研究交流会

作者： Zhang X Liu JP Wang BB Yu H Fang J Yin ZM Zhang YL Xiong M Department of Gynecologic Oncology and Medical Radiation Physics Zhejiang Cancer Hospital

Purpose To evaluate coverage of clinical target volume(CTV) influenced by interfraction uterus movement and cervical tumor regression and determine suitable planning margin for intact cervical cancer. Methods and Materials 5 patients undergoing external beam radiotherapy(EBRT) were asked to fill their bladders and empty rectums before computed tomography(CT) simulation and every fraction of *** target volume(PTV) margin was *** beam computed tomography(CBCT) was performed and images were registered

关键词： Image-guided radiation therapy CBCT Intensity-modulated radiation therapy uterus movement tumor regression intact cervical cancer

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Bioprocessed Black Rice Bran Potentiates the Growth Inhibitory Activity of an Immune Checkpoint Inhibitor against Murine Colon Carcinoma

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Food and Nutrition Sciences 2023年第12期14卷 1149-1171页

作者： Kyung Hee Lee Ki Sun Kwon Woon Sang Hwang Wha Young Lee Jeanman Kim Sang Jong Lee Sung Phil Kim Mendel Friedman STR Biotech Co. Ltd. Chuncheon Republic of Korea U.S. Department of Agriculture Western Regional Research Center Agricultural Research Service Albany CA USA

This study determined the effect of orally fed polysaccharide-rich bioprocessed (fermented) black rice bran produced by culturing with shiitake (Lentinus edodes) mushroom mycelium on CT-26 colon cancer cells in vivo in an intracutaneously transplanted mouse tumor alone and in combination with intraperitoneally administered anti-PD-1 immune checkpoint inhibitor. Analysis of the isolated tumor weights at the end of the study shows that the average tumor size in control mice is 3.78 grams, and the average tumor size in mice treated with anti-PD-1 antibody is 2.16 grams. The average tumor size in mice treated with BRB-F alone is 2.25 grams, and the average tumor size in mice treated with anti-PD-1 antibody BRB-F combination is 1.38 grams. Thus, BRB-F or anti-PD-1 antibody alone each reduce tumor size by 40.5% or 42.9%, whereas the combination of BRB-F and anti-PD-1 antibody reduces tumor size by 63.5%, with their cooperative effect being statistically significant. The observed anti-tumor effects were accompanied by a series of biomarkers associated with cancer formation and inhibition. These results indicate that the reported potentiation of cancer therapy using drug-based medical chemotherapies with added checkpoint inhibitors in human patients are mechanistically similar with the functional food evaluated in the present study. These beneficial effects in mice challenge clinicians to investigate if the black rice bran food product can also protect against human cancer.

关键词： Black Rice Bran Mushroom Mycelia Bioprocessing Immune Checkpoint Inhibitor Mice tumor regression Cancer Prevention Biomarkers Mechanism Research Needs

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MR IMAGING ASSESSMENT OF IRREGULAR SHRINKAGE OF tumor MORPHOLOGY AND VOLUME IN CERVICAL CANCER DURING RADIATION THERAPY

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Chinese Journal of Cancer Research 2004年第2期16卷 137-141,149页

作者：李文彬李明华崔雪娥 WilliamT.C.Yuh NinaA.Mayr Department of Radiology Affiliated Sixth People'S Hospital Shanghai Jiaotong University Shanghai 200233 China Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA Radiation Oncology Center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

To study the clinical significance of the morphological and volume changes in cervical cancer during an ongoing course of radiation therapy (RT) using MR imaging. Methods: Serial MR imaging examinations were performed in 60 advanced cervical cancer patients. MR imaging was obtained at the start of RT, at 20-25 Gy (2-2.5 weeks of RT), at 45-50 Gy (4-5 weeks of RT), and 1-2 month post-RT. tumor morphology was classified qualitatively as well-defined (round/oval with a well-demarcated smooth margin) vs. lobulated vs. irregular and tumor volume was assessed in each serial MR examination independently by ROI volumetry and diameter volumetry. ROI volumetry was traced on the computer workstation with a trackball in each sagittal T2-weighted image and calculated by the summation of all tumor areas in each slice and multiplication by the slice profile. Diameter volumetry was to measure the largest three orthogonal tumor diameters in each orthogonal measurement plane and calculate as an ellipsoid formula (V=d1 x d2 x d3 x p/6). Serial tumor volume was compared between the two measurement methods. Results: The proportion of lobulated and irregular tumors increased early during RT and declined lately post-RT (68% pre-RT, 80% at 2-2.5 weeks of RT, 72% at 4-5 weeks of RT, 33% post-RT). Accordingly, ROI volumetry and diameter volumetry correlated well pre-RT (r1=0.89) and post-RT (r4=0.80), but poorly during RT (r2 = 0.17 at 2-2.5 weeks of RT, r3 = 0.69 at 4-5 weeks of RT). Conclusions: Cervical cancers regress in a non-uniform fashion during RT and undergo increasingly irregular shrinkage. Measurement with ROI volumetry techniques, which can optimally measure irregular volumes, provides better assessment of radiation response during treatment than diameter volumetry.

关键词： Cervical cancer MR imaging tumor volume Radiation therapy tumor regression

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