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Investigation of Some Possible Mechanisms Involved in the Anticonvulsant Activity of tulbaghia violacea Harv

Journal of Pharmacy and Pharmacology 2017年第9期5卷 616-627页

作者： K. A. A. Masoud Okobi E Ekpo G. J. Amabeoku Department of Medical Biosciences University of the Western Cape Bellville 7535 South Africa School of Pharmacy Faculty of Natural Science University of the Western Cape Bellville 7535 South Africa

Even though tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the plant species in therapy. This study was intended, therefore, to investigate the anticonvulsant effect of the leaf methanol extract of tulbaghia violacea by studying its effect against tonic convulsion induced by either PTZ （pentylenetetrazole）, bicuculline, picrotoxin, strychnine or NMDLA （N-methyl-DL-aspartic acid） in mice. Qualitative phytochemical analysis, acute toxicity and HPLC studies were also carried out on the plant species. Leaf methanol extract of tulbaghia violacea, phenobarbitone, diazepam or muscimol significantly antagonised PTZ, bicuculline or picrotoxin-induced convulsion. Combined treatment of sub-effective doses of T. violacea and muscimol significantly antagonised tonic convulsion induced by PTZ. T. violacea or phenobarbitone significantly antagonised strychnine-induced tonic convulsion. T. violacea or LY233053 significantly antagonised NMDLA-elicited tonic convulsion. Phenytoin or DMSO （dimethylsulfoxide） did not significantly affect the tonic convulsion produced by PTZ, bicuculline, picrotoxin, strychnine or NMDLA. The phytochemical qualitative analysis of the plant species showed the presence of alkaloids, saponins, reducing sugars, flavonoids, cardiac glycosides, triterpene steroids, quinones and tannins. The LD50 value obtained following oral administration of the plant extract was over 4000 mg/kg. The data in the present study indicate that the leaf methanol extract of T. violacea has anticonvulsant activity which is probably underpinned by GABAergic, glutaminergic and glycinergic mechanisms.

关键词： tulbaghia violacea alliaceae anticonvulsant properties GABAergic glutamatergic and glycinergic mechanisms mice.

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Impact of Different Landscaping Waste Biochar Return-to-soil Modes on Plant Growth

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Journal of Landscape Research 2017年第2期9卷 82-84页

作者： QIAN Xinfeng Changshu Bureau of Housing and Urban-Rural Construction Changshu Urban Landscaping Office

Processing landscaping waste into biochar has been just initiated in China, biochar as a new soil improver has attracted wide concern home and abroad. This paper applied the pilot experiment method, and took tulbaghia violacea and Malus micromalus cv. "American" as the test flower and tree to explore the impact of different biochar return-to-soil modes on plant growth. It was found that biocharcoveredsoil promoted the growth of both species efficiently, and relieved the poor growth, compared with the control group, biochar-covered-soil reduced yellow leaves, dead leaves and poor growth vigor of *** by 47.8%, 20% and 100%, respectively, and it reduced poor growth, dead branch rate and root tiller germination of M. micromalus cv. "American" by 80%, 62.5% and 50%. The results showed that biocharcoveredsoil was better than biochar-mixing-soil.

关键词： Biochar returning to soil tulbaghia violacea Malus micromalus cv "American" Impact on growth

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