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Protective mechanisms of tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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中医杂志:英文版 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi YU Tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing GUAN Qian CHEN Lulu HU Hui School of Acupuncture-Moxibustion and tuina Beijing University of Chinese MedicineBeijing 102401China Department of Acupuncture-Moxibustion Beijing Massage HospitalBeijing 100035China Department of Acupuncture-Moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant rabbits.METHODS:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and tuina.The fever model was established by injecting LPS intravenously through the ear margin vein in the model group and tuina group,respectively.The modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 h.In the tuina group,six tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given tuina treatment,with the real-time anal temperature monitored during the experiment.The plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics study.RESULTS:Our results showed a fever-reducing effects of tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and hypothalamus.The differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the tuina intervention.tuina primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic pathways.CONCLUSION:tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action possibly associated with the changes in plasma metab

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine tuina therapy

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Traditional Chinese medicine ointment combined with tuina therapy in treatment of pain and swelling after total knee arthroplasty

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World Journal of Orthopedics 2022年第10期13卷 932-939页

作者： Liang Xing Hui-Rong Xu Qing-Lin Wang Hua Kong Hua Zhang Jing Tian Ying Ding Ru-Xin Yang Lei Zhang Bo Jiang Department of Arthroscopy and Sports Medicine Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Nursing Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Vascular Surgery Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Orthopedics Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Spine Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

BACKGROUND The most effective treatment for knee joint pain is total knee arthroplasty(TKA),but the risk of pain and swelling in patients after surgery is high.Ice application,ankle pump exercise and non-steroidal anti-inflammatory painkillers are the primary clinical treatments after surgery.However,long-term use of nonsteroidal anti-inflammatory pain relievers can easily cause gastrointestinal damage.Traditional Chinese medicine(TCM)ointments and tuina therapy integrate TCM and manipulation,which effectively promotes the penetration of TCM into the skin lesions,improves local blood circulation and inflammatory reaction and has good long-term effects on patients.AIM To evaluate the efficacy of TCM ointment combined with tuina therapy in the treatment of pain and swelling after TKA.METHODS The randomized controlled clinical trial enrolled 80 patients who underwent TKA via the same procedure.The patients were randomly divided among the treatment group(n=40)and the control group(n=40).The control group was given an analgesia pump in addition to oral painkillers as the postoperative intervention.The treatment group received TCM ointment with tuina therapy in addition to the analgesia pump and oral painkillers in the postoperative period.The following variables were recorded 3 d before surgery and 3 d,7 d and 14 d after surgery:Visual analogue scale(VAS)score;skin temperature;circumferences at 15 cm above and below the patella;maximum active knee flexion angle;and the knee injury and Osteoarthritis Outcome score(KOOS).RESULTS After treatment,VAS was significantly lower in the treatment group than the control group at 7 d(t=7.536,P<0.001)and 14 d(t=8.563,P<0.001).The skin temperature of participants in the treatment group was significantly lower than that in the control group at 7 d(t=2.968,P=0.004)and 14 d(t=4.423,P<0.001).The circumference values of the two positions in the treatment group were lower than those in the control group at 7 d[t=2.315,P=0.023(above);t=2.121,P=0.037(below)]and 14 d[t=2.374,P=0.020(above);

关键词： Traditional Chinese medicine ointment tuina therapy Total knee arthroplasty Pain Swelling

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