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Synergistic activity of lawsone methyl ether in combination with some antibiotics and artocarpin against methicillin-resistant Staphylococcus aureus, Candida albicans, and trychophyton rubrum

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Chinese Herbal Medicines 2019年第3期11卷 321-325页

作者： Pharkphoom Panichayupakaranant Abdi Wira Septama Akarawat Sinviratpong Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-YaiSongkhla 90112Thailand Phytomedicine and Pharmaceutical Biotechnology Excellence Center Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-YaiSongkhla 90112Thailand Research Center for Chemistry Indonesian Institute of SciencesKawasan PUSPIPTEK SerpongTangerang SelatanBanten 15314Indonesia

Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens balsamina. The objective of this study is to determine the interaction of LME with some antibiotics(ampicillin, tetracycline, norfloxacin, and clotrimazole) and a natural compound, artocarpin against methicillin-resistant Staphylococcus aureus(MRSA), Candida albicans, and trychophyton ***: A broth microdilution method was used to determine the minimum inhibition concentration(MIC). Synergistic effects were evaluated at their own MIC using the checkerboard method and time-kill ***: LME showed moderate antibacterial activity against MRSA with MIC value of 15.6 μg/mL, and exhibited strong antifungal activities against T. rubrum and C. albicans with MIC values of 7.8 and 3.9 μg/m L,respectively. The interaction of LME with the natural compound artocarpin against MRSA produced a synergy with fractional inhibitory concentration index(FICI) value of 0.31, while the combination of LME and clotrimazole exhibited synergy against C. albicans and T. rubrum with FICI values of 0.38 and 0.24, respectively. The time-kill assays confirmed that the compounds in combination enhanced their antimicrobial activities against the resistant microorganisms with different ***: LME in combination with clotrimazole exhibited synergy effect against C. albicans and ***. In combination with artocarpin, it showed synergy effect against MRSA.

关键词： artocarpin Candida albicans clotrimazole lawsone methyl ether Staphylococcus aureus synergy trychophyton rubrum

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