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troponin I测定对儿童心肌炎的诊断意义

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江苏临床医学杂志 2001年第2期5卷 120-120,122页

作者：周兆群陆超南京医科大学附属南京儿童医院南京2100081 江苏省人民医院南京210029

为评估心肌特异性肌钙蛋白Ⅰ在儿童心肌炎中的诊断意义,作者应用酶联免疫吸附测定法(ELISA)检测41例心肌炎患儿心肌特异性肌钙蛋白Ⅰ(troponin Ⅰ,cTN-Ⅰ)和CK-MB,并与正常对照组31例进行比较,现将结果报告如下.

关键词： troponinⅰ CK-MB 心肌炎儿童诊断

In situ formation of fluorescent silicon-containing polymer dots for alkaline phosphatase activity detection and immunoassay

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Science China Chemistry 2020年第4期63卷 554-560页

作者： Guoyong Liu Jiahui Zhao Mengxia Yan Shuyun Zhu Wenchao Dou Jian Sun Xiurong Yang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Chemical Engineering Qufu Normal UniversityQnfu 273165China Food Safety Key Laboratory of Zhejiang Province College of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

The discovery and application of analyte-triggered fluorophore generation or fluorogenic reaction are significant and beneficial to the development of novel fluorescence(FL) analysis method. In this study, for the first time, we have reported a fluorogenic reaction to prepare fluorescent silicon-containing polymer dots(Si-PDs) by simply mixing N-[3-(trimethoxysilyl)propyl]ethylenediamine(DAMO) and hydroquinone(HQ) in aqueous solution at ambient temperature. Inspired by the alkaline phosphatase(ALP)-catalyzed hydrolysis of the substrate sodium 4-hydroxyphenyl phosphate(4-HPP) into HQ and the resultant HQcontrolled intense green Si-PDs generation, we have established a straightforward ALP activity assay by innovatively employing commercially available 4-HPP as the substrate. More significantly, the specific preparation method, clear formation mechanism and excellent performance enable the Si-PDs as well as its generation process to develop facile and attractive FL *** the help of the universal ALP-based enzyme-linked immunosorbent assay(ELISA) platform and corresponding antibody, a convenient and conceptual ALP-based fluorescent ELISA has been constructed and applied in sensing cardiac troponin Ⅰ(cTnI),a well-known biomarker of acute myocardial infarction. Our research via in situ formation of fluorescent nanomaterials has great potential application in ALP activity assay, inhibitor screening, and disease diagnosis.

关键词： fluorescent polymer dots ELISA alkaline phosphatase cardiac troponinⅰ

Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations

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Science China(Life Sciences) 2020年第4期63卷 563-570页

作者： Weian Zhao Xiaoqi Wu Zhiyuan Wang Bo Pan Lifei Liu Lingjuan Liu Xupei Huang Jie Tian Department of Cardiology Heart CentreChildren’s Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersKey Laboratory of Pediatrics in ChongqingChongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqing 400014China Department of anesthesiology The Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Biomedical Science Charlie E.Schmidt College of MedicineFlorida Atlantic UniversityBoca Raton 33414USA

Epigenetic regulations play an important role in disease *** this study,we have investigated epigenetic regulations in restrictive cardiomyopathy mice with cTnI 193 His *** results demonstrated that phosphodiesterase(PDEs)4d was down-regulated in the heart of these *** studies showed that the epigenetic modifications were associated with enhanced acetylation of histone 3 lysine 4 and lysines 9,whereas tri-methylation of histone 3 lysine 4,were decreased in histones near the PDE4d gene promoter *** binding levels of histone transmethylase SMYD1 and histone deacetylase HDAC1 were increased in the gene promoter regions in cTnI193 His transgenic *** immune-fluorescent labeling we found an evidence of cTnI existence in the nucleus of cardiomyocytes and Western blotting further confirmed that both wild type and mutated cTnI could be detected in the cell nucleus of the ***,an interaction between cTnI and SMYD1,or cTnI and HDAC1 was *** of the mutated cTnI in cultured cardiomyocytes reduced the expression of *** data suggest that the decrease of PDE4d expression in RCM mice caused by cTnI mutations may be related to epigenetic regulation,i.e.,histone acetylation and methylation,and cTnI might be involved in this procedure via an interaction with HDAC1 and SMAD1 in the hearts.

关键词： phosphodiesterase epigenetics histone modifications restrictive cardiomyopathy cardiac troponinⅰ

脑钠素与肌钙蛋白Ⅰ在小儿心力衰竭诊断中的应用

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国际医药卫生导报 2016年第2期22卷 255-257页

作者：曲旭亮莱州市人民医院检验科 261400

目的探讨脑钠素与肌钙蛋白Ⅰ在小儿心力衰竭诊断中的应用.方法收集我院2013年1月至2015年8月收治的心力衰竭患儿160例随机分为四组,每组40例,并另选40例健康儿童儿归为非心衰组.其中对四组患儿分别以BNP单独诊断、CYn Ⅰ单独诊断、BNP... 详细信息

目的探讨脑钠素与肌钙蛋白Ⅰ在小儿心力衰竭诊断中的应用.方法收集我院2013年1月至2015年8月收治的心力衰竭患儿160例随机分为四组,每组40例,并另选40例健康儿童儿归为非心衰组.其中对四组患儿分别以BNP单独诊断、CYn Ⅰ单独诊断、BNP与CYnⅠ串联诊断与BNP与CYn Ⅰ并联诊断,比较心衰儿童与非心衰患儿各时期BNP与CYn Ⅰ水平与四种诊断方法的诊断效能.结果心衰组患儿BNP与CYn Ⅰ水平在心衰早期[（633.21±80.24）,（0.135±0.036）]、心衰期[（1 043.87±201.34）,（0.429±0.034）]与恢复期[（874.23± 97.14）,（0.196±0.029）]均显著性高于非心衰组[（90.58±6.72）,（0.042±0.016）,（90.61±6.82）,（0.043±0.014）,（90.16±6.91）,（0.041±0.009）],差异具有统计学意义（P＜0.01）;单独诊断中,BNP诊断特意度（92.31％）较高,误诊率（7.69％）低,CYnⅠ单独诊断敏感度（94.59％）高,漏诊率（5.41％）低;BNP与CYnⅠ并联诊断敏感度（94.87％）、特异度（92.68）、诊断符合率（93.75％）、阳性预测值（92.50％）与阴性预测值（95.00％）最高,漏诊率（5.13％）与误诊率（7.32％）最低;BNP与CYn Ⅰ串联诊断效能最差.结论脑钠素与肌钙蛋白Ⅰ在小儿心力衰竭诊断具有重大的意义,优先选用BNP与CYnⅠ并联诊断,具有借鉴性.

关键词：脑钠素肌钙蛋白Ⅰ 心力衰竭并联诊断串联诊断 Cardiac troponinⅰ

心肌钙蛋白在小儿先天性心脏病介入治疗中的变化

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中华儿科杂志 2005年第12期43卷 935-936页

作者：秦玉明王大为杨世伟曹黎明赵乃琤钱建华龚晓平王凤鸣胡宝珍南京医科大学附属南京市儿童医院心内科 210008

心肌肌钙蛋白Ⅰ（cardiac troponinⅰ，cTn—Ⅰ）已作为一种高度特异和敏感的心肌损伤标志物在临床得到广泛的应用。[第一段]

关键词：心脏病介入治疗心肌钙蛋白先天性 troponinⅰ 心肌肌钙蛋白Ⅰ 心肌损伤标志物小儿 cTn

肌钙蛋白Ⅰ与慢性心力衰竭患者心脏结构及功能的相关性研究

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山西医药杂志（上半月） 2012年第2期41卷 157-158页

作者：吴琼贾志梅中国医科大学附属第四医院 110032 中国医科大学附属第一医院

近年来心脏肌钙蛋白Ⅰ（cardiac troponinⅰ,cTnⅠ）不但广泛用于诊断冠心病、急性心肌梗死,亦有关于其在慢性心力衰竭（chronic heart failure,CHF）诊断与预后中应用价值的相关报道[1],但其与CHF左心功能的关系并不明确。本研究旨在探... 详细信息

近年来心脏肌钙蛋白Ⅰ（cardiac troponinⅰ,cTnⅠ）不但广泛用于诊断冠心病、急性心肌梗死,亦有关于其在慢性心力衰竭（chronic heart failure,CHF）诊断与预后中应用价值的相关报道[1],但其与CHF左心功能的关系并不明确。本研究旨在探讨CHF患者血清cTnⅠ水平与心脏结构及功能的相关性以及其临床意义。

关键词：慢性心力衰竭患者心脏肌钙蛋白Ⅰ 心脏结构相关性 troponinⅰ CHF患者急性心肌梗死 cTnⅠ

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心脏型脂肪酸结合蛋白的研究进展

实用医学杂志 2008年第7期24卷 1253-1254页

作者：王红艳(综述) 赵晓云(审校) 河北省人民医院临研中心省级老年病重点实验室石家庄市050017

近年来，在世界范围内急性心肌梗死（acute myocardial infarction，AMI）发病率持续升高，而对AMI的治疗，再灌注治疗的效果与时间呈显著负相关，早期诊断和治疗具有相当重要的意义。目前临床对于不典型症状或心电图者AMI诊断更多依赖... 详细信息

近年来，在世界范围内急性心肌梗死（acute myocardial infarction，AMI）发病率持续升高，而对AMI的治疗，再灌注治疗的效果与时间呈显著负相关，早期诊断和治疗具有相当重要的意义。目前临床对于不典型症状或心电图者AMI诊断更多依赖于心肌酶学，而肌红蛋白（myoglobin，MYO）、肌钙蛋白Ⅰ（troponinⅰ，cTnI）及肌酸磷酸激酶（creatine kinasemass，CK-MB）对早期诊断AMI的灵敏度或特异性方面存在缺陷，近年发现心脏型脂肪酸结合蛋白（heart fatty acidbinding pro-tein,H-FABP）早期诊断缺血性心肌损伤的有效性,现综述如下。

关键词：心脏型脂肪酸结合蛋白 troponinⅰ 再灌注治疗 AMI诊断缺血性心肌损伤急性心肌梗死早期诊断肌酸磷酸激酶