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Co-infection of Chlamydia psittaci and tropheryma whipplei: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7144-7149页

作者： Zhu-Man Du Pei Chen Respiratory and Critical Care Discipline Clinical Medicine CollegeAffiliated Hospital of Chengdu UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND The co-infection of Chlamydia psittaci(***)and tropheryma whipplei(***)is unusual,and the detection of pathogenic microorganisms is particularly important for patients with severe diseases or poor experience in *** identification of pathogens can significantly improve the prognosis of the *** next-generation sequencing(tNGS)is currently widely used in clinical practice for various infectious diseases,including respiratory infections,to achieve early,accurate,and rapid microbial *** SUMMARY We report a case of a 40-year-old female patient with a history of contact with parrots who was diagnosed with *** and *** infection through bronchial lavage fluid targeted next generation *** moxifloxacin treatment,the patient's symptoms improved significantly,and the imaging changes were obviously *** Coinfection with *** and *** is not *** this case,timely and accurate identification of both pathogens was achieved using ***,the efficacy of monotherapy with moxifloxacin was confirmed.

关键词： Infectious diseases Chlamydia psittaci tropheryma whipplei Targeted next generation sequencing Case report

A case of Noonan syndrome and Whipple's disease in the same patient

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World Journal of Gastroenterology 2009年第12期15卷 1524-1527页

作者： Sundip S Karsan Hetal A Karsan Anand S Karsan James Ian McMillen Cedars-Sinai Medical Center 8700 Beverly BlvdRoom 5512Los AngelesCaliforniaCA 90048United States Emory University School of Medicine and Atlanta Gastroenterology Associates AtlantaGA 30322United States University of California San DiegoCA92093United States Atlanta Clinical Care and Atlanta Specialty Research AtlantaGA 30322United States

We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and hands with a diffuse hyperpigmented rash,night sweats,and an unintentional fifteen pound weight loss over 4 *** bowel enteroscopy demonstrated mild edematous yellowish mucosa without *** small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy *** was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status.

关键词： Whipple's disease Noonan syndrome tropheryma whipplei Periodic acid-schiff stain PTPN11 gene

Atypical Whipple’s disease with special endoscopic manifestations:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13044-13051页

作者： Shuo Chen Yuan-Chen Zhou Shuang Si Hong-Yan Liu Qing-Rui Zhang Teng-Fei Yin Chu-Xi Xie Shu-KunYao Shi-Yu Du Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Peking University China-Japan Friendship School of Clinical Medicine Peking UniversityBeijing 100029China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Whipple’s disease is a rare systemic infection caused by tropheryma *** patients present with nonspecific symptoms,and routine laboratory and imaging examination results also lack *** diagnosis often relies on invasive manipulation,pathological examination,and molecular *** difficulties in diagnosing Whipple’s disease often result in misdiagnosis and inappropriate *** SUMMARY This paper reports on the case of a 58-year-old male patient who complained of fatigue and decreased exercise *** results of routine blood tests indicated hypochromic microcytic *** of gastroscopy and capsule endoscopy showed multiple polypoid bulges distributed in the duodenal and proximal jejunum.A diagnosis of small intestinal adenomatosis was initially considered;hence,the Whipple procedure,a pylorus-preserving pancreaticoduodenectomy,was *** manifestations showed many periodic acid-Schiff-positive macrophages aggregated in the intestinal mucosa of the duodenum,upper jejunum,and surrounding lymph *** on comprehensive analysis of symptoms,laboratory findings,and pathological manifestations,the patient was finally diagnosed with Whipple’s *** receiving 1 mo of antibiotic treatment,the fatigue and anemia were significantly *** This case presented with atypical gastrointestinal manifestations and small intestinal polypoid bulges,which provided new insight on the diagnosis of Whipple’s disease.

关键词： Whipple’s disease Whipple operation Endoscopy tropheryma whipplei PAS staining Intestinal polyposis Case report

Complicated Whipple's disease and endocarditis following tumor necrosis factor inhibitors

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World Journal of Cardiology 2014年第12期6卷 1278-1284页

作者： Thomas Marth Division of Internal Medicine Krankenhaus Maria Hilf54550 Daun Germany

AIM: To test whether treatment with tumor necrosis factor inhibitors(TNFI) is associated with complications of tropheryma whipplei(T. whipplei) infection. METHODS: Because unexplained arthritis is often the first Whipple’s disease(WD) symptom, patients may undergo treatment with TNFI before diagnosis. This may influence the course of infection with T. whipplei, which causes WD, because host immune defects contribute to the pathogenesis of WD. A literature search and cross referencing identified 19 reports of TNFI treatment prior to WD diagnosis. This case-control study compared clinical data in patients receiving TNFI therapy(group Ⅰ, n = 41) with patients not receiving TNFI therapy(group Ⅱ, n = 61). Patients from large reviews served as controls(group Ⅲ, n = 1059).RESULTS: The rate of endocarditis in patient group Ⅰ was significantly higher than in patient group Ⅱ(12.2% in group Ⅰ vs 1.6% in group Ⅱ, P whipplei was more accurate than PAS-stainings(diagnostic accuracy, rate of true positive tests 90.9% for PCR vs 36.4% for PAS, P whipplei should be considered.

关键词： Arthritis Complication Endocarditis Periodic acid-Schiff stain Polymerase chain reaction tropheryma whipplei Whipple's disease