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trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy

World Journal of Gastroenterology 2005年第1期11卷 89-93页

作者： Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki Molecular Gastroenterology and Hepatology Molecular Hematology and Oncology Department of Internal Medicine Department of Pathology and Clinical Laboratories School of Nursing Clinical Molecular Genetics and Laboratory Medicine

AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of ***: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. trisomy 7 was not detected in this series of ***: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. trisomy 3 may predict the aggressive development of MALT lymphoma.

关键词： Helicobacter pylori infection Gastric MALT lymphoma trisomy 3

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Complete or partial trisomy 3 in gastro-intestinal MALT lymphomas co-occurs with aberrations at 18q21 and correlates with advanced disease stage:A study on 25 cases

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World Journal of Gastroenterology 2005年第46期11卷 7384-7385页

作者： Jens Krugmann Alexandar Tzankov Stephan Dirnhofer Falko Fend Dominik Wolf Reiner Siebert Pensiri Probst Martin Erdel Institute of PathologyMedical University of Innsbruck Austria Department of Medical GeneticsMolecular and Clinical PharmacologyMedical University of InnsbruckAustria Institute of PathologyMedical University of Innsbruck Austria Institute of PathologyUniversity of Basel Switzerland Institute of PathologyTechnical University of Munich Germany Department of Internal MedicineDivision of Hematology/Oncology Medical University of InnsbruckAustria Institute of Human GeneticsUniversity Hospital Schleswig-Holstein Campus Kiel Germany Department of Medical GeneticsMolecular and Clinical Pharmacology Medical University of InnsbruckAustria

Taji et al . have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue （MALT） lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alphasatellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas .

关键词： MALT lymphoma trisomy 3 trisomy 18

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