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Efficacy of Bushen Culuan decoction(补肾促卵方)on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency induced by Tripterygium wilfordii polyglycoside

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Journal of Traditional Chinese Medicine 2022年第1期42卷 23-29页

作者： MA Kun YUAN Yuan CHEN Yanxia YUAN Bochao WANG Kaili TIAN Caidie LI Jiani the Department of Educational Management China Academy of Chinese Medical ScienceBeijing 100007China Xiyuan Hospital China Academy of Chinese Medical ScienceBeijing 100091China

OBJECTIVE:To investigate the protective efficacy of Bushen Culuan decoction补肾促卵方,BCD)on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency(POI)induced by Tripterygium wilfordii polyglycoside,and to study the potential mechanism underlying the action.METHODS:Eighty female Balb/c mice were randomly divided into 4 groups(n=20 each):blank group,model group,Bushen Culuan decoction intervening group(BCD group)and estradiol valerate intervening group(EV group).In the first 14 model establishing d,mice in model group,BCD group and EV group were under Tripterygium wilfordii polyglycoside(TWP)gavage to establish POI models.In the 14-day therapeutic stage,mice in BCD group were taken BCD 18.35 mg·kg^(-1)·d^(-1),mice in EV group were taken EV solution 0.15 mg·kg^(-1)·d^(-1),while mice in blank group and model group were taken normal saline.When the mice accomplished therapy,whole blood was collected for serum hormone including follicle stimulating hormone(FSH),luteal hormone(LH),estradiol(E2),antimullerian hormone(AMH)levels and vascular endothelial growth factor(VEGF),bone morphogenetic protein-7(BMP-7)measurement.Ovarian tissues were harvested for morphologic observation,follicle counting,ovarian follicular graulosa cell apoptosis test and testing BMP-7 and caspase-3 expressions.RESULTS:The body weights of the mice kept growing stably in the process expect in TWP intervening stage.Compared with model group,BCD group had significantly higher ovarian index,serum E_(2),AMH,VEGF,BMP-7 levels and significantly lower FSH level(P<0.05).Meanwhile the VEGF level in BCD group was higher than in EV group(P<0.05).Compared with model group,the histopathological damage and GCs apoptosis were mitigated;developing follicle counting,BMP-7 expression were up-regulated,and caspase-3 expression was downregulated in BCD groups(P<0.05).CONCLUSION:BCD treatment could attenuate pathological process in POI ovaries,suppress GC apoptosis,probably through promoting BMP-7 expression and following inhibiting ca

关键词： primary ovarian insufficiency Tripterygium granulosa cells apoptosis Bushen Culuan decoction

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Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice

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Frontiers of Medicine 2019年第5期13卷 556-563页

作者： Dan Luo Zhengyun Zuo Hongyan Zhao Yong Tan Cheng Xiao Traditional Chinese Medicine Hospital of Changping District Beijing 102200China Institute of Clinical Medicine China-Japan Friendship HospitalBeijing 100029China Jiangxi University of Traditional Chinese Medicine Nanchang 330004China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100070China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100070China

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

关键词： Tripterygium mlfordii Hook F immunoregulation clinical studies

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Benefits and Safety of Tripterygium Glycosides and Total Glucosides of Paeony for Rheumatoid Arthritis: An Overview of Systematic Reviews

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Chinese Journal of Integrative Medicine 2019年第9期25卷 696-703页

作者： LUO Jing SONG Wei-jiang XU Yuan CHEN Guang-yao HU Qi TAO Qing-wen Traditional Chinese Medicine Department of Rheumatism China-Japan Friendship Hospital Beijing 100029 China Traditional Chinese Medicine Department Peking University Third Hospital Beijing 100191 China Graduate School Beijing University of Chinese Medicine Beijing 100029 China

Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China, for patients with RA. Methods: SRs of randomized controlled trials(RCTs) on TG or TGP in treating RA were included, by searching 8 databases from their inception until December 2017. Two authors extracted data independently. We assessed the quality of SRs using AMSTAR and graded the quality of evidence according to the GRADE approach. Results: Eleven SRs containing an average of 7.6 RCTs, involving a total of 7,012 participants were included in this overview. On the basis of included SRs, TG and TGP could improve the following indexes for RA patients: American College of Rheumatology(ACR) 20 response rate, ACR50 response rate and ACR70 response rate, swollen joint count, tender joint count, erythrocyte sedimentation rate and C-reactive protein. Moreover, TGP could reduce incidence of hepatotoxicity. The most common adverse effects of TG were gastrointestinal discomfort and gonad toxicity, while for TGP was mild to moderate diarrhea. The overall quality of evidence for these findings ranged from "low" to "moderate". Conclusions: TG and TGP might be 2 potentially effective complementary and alternative drugs for patients with RA. Nevertheless, due to gonad toxicity, TG should only be considered in elderly patients or patients without reproductive needs. More evidence from high quality RCTs and SRs is warranted to support the use of TG and TGP for RA patients.

关键词： rheumatoid arthritis Tripterygium glycosides total glucosides of paeony overview systematic review

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Effects of adding Tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy

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Chronic Diseases and Translational Medicine 2020年第1期6卷 18-26页

作者： Fang Jin-Ying Yang Yue Zhang Zheng Jiang Shi-Min Yu Tian-Yu Li Wen-Ge Beijing University of Chinese Medicine Beijing 100029China Department of Nephrology China-Japan Friendship HospitalBeijing 100029China

Introduction::Tripterygium glycosides (TGs) have been widely used in China to treat diabetic nephropathy (DN);however, proof of their use is scarce. The present study aimed to evaluate the effectiveness and safety of adding TGs to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs).Methods::By searching Embase, MEDLINE, Cochrane Library, SINOMED, China National Knowledge Infrastructure, VIP Information/Chinese Scientific Journals, and WANFANG databases, we identified previous studies that met the specific selection criteria and included them in the meta-analysis. Analyses were performed using Review Manager (version 5.3).Results::Nine randomized controlled trials were included in the final meta-analysis. Patients were compared before and after treatment with ACE inhibitors or ARBs plus TGs, or ACE inhibitors or ARBs alone. The results revealed that treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in 24-h urinary total protein (UTP) levels (trial duration 6 months, MD: -2.09;95% CI: -2.89, -1.29) compared with treatment using ACE inhibitors or ARBs alone. Additionally, ACE inhibitors or ARBs plus TGs showed better results after longterm administration. Treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in serum creatinine (SCr) compared with ACE inhibitors or ARBs alone (MD: -9.87;95% CI: -13.76, -5.97). Conclusion::In patients with DN, adding TGs to ACE inhibitors or ARBs significantly lowered both the 24-h UTP and SCr levels. Therefore, ACE inhibitors or ARBs plus TGs might improve the treatment of DN in patients.

关键词： Tripterygium glycosides Diabetic nephropathy Angiotensin-converting enzyme inhibitor Angiotensin receptor blockers Metaanalysis

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Effect of cream, prepared with Tripterygium wilfordii Hook F and other four medicinals, on joint pain and swelling in patients with rheumatoid arthritis: a double-blinded, randomized, placebo controlled clinical trial

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Journal of Traditional Chinese Medicine 2019年第1期39卷 89-96页

作者： Jiao Juan Wei Chengchung Tang Xiaopo Gong Xun Yin Haibo Jiang Quan Department of Rheumatology Guang'anmen Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing 100053China Division of Allergy Immunology and RheumatologyChung Shan Medical University HospitalInstitute of MedicineChung Shan Medical UniversityGraduate Institute of Intergrated MedicineChina Medical UniversityTaichung 40201Taiwan China

OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Nalrii Sulfas), Chuanxiong(Rhizoma Chuanxiong), stir-frying with liquid adjuvant Ruxiang(Olibanum), and stir-frying with liquid adjuvant Moyao(Myrrh).METHODS: Patients were 1∶1 randomized to addon TwHF cream twice a day or placebo for 4 weeks.The primary endpoint was achievement rate of20% improvement in American College of Rheuma-tology criteria(ACR20) at week 4. Secondary endpoints were ACR50, 28-joint count Disease Activity Score(DAS28) improvement and safety profiles.Statistical analyses were performed using intention to treat analysis(ITT) set.RESULTS: A total of 70 active RA patients were enrolled. At week 4, the ACR20 was 34.3%(12/35) in TwHF cream group and 11.4%(4/35) in placebo group(P = 0.015). Similarly, a higher ACR50 responder proportion was seen in TwHF cream group with 17.1%(6/35) comparing to it in placebo group with 2.9%(1/35)(P = 0.046). The TwHF cream group also had more improvement than the placebo group on DAS28-ESR(1.1 vs 0.5, P = 0.001), DAS28-CRP(1.4 vs 0.7, P = 0.001), tender joint count(5.5 vs2.6, P = 0.018), swollen joint count(3.5 vs 1.6, P =0.003) and Physician's global assessment(25.8 vs13.0, P = 0.002), as well as C-reactive protein(11.2 vs 2.7, P = 0.048). Except 2 skin allergy events in TwHF cream group, no other substantive adverse events were observed.CONCLUSION: On the short term, TwHF cream is likely to be an effective and safety complimentary treatment in patients with active RA.

关键词： Tripterygium wilfordii Arthritis,rheumatoid External therapy Randomized controlled trial

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Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schönlein purpura nephritis in children

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世界儿科杂志:英文版 2016年第3期12卷 375-375,376页

作者： Shu-Jiong Mao Xian-Mei Huang Department of Pediatrics Hangzhou First People's HospitalHangzhouChina

I read with interest the recently published article by Huang et al.[1]The article is very informative and has brought an utmost important insight on chronic glomerulonephritis in children.It is an interesting issue,because glomerulonephritis such as Schonlein-Henoch nephritis(HSPN)may lead to renal failure in children and adolescents.The well-presented clinical features and histopathological changes described in the article are valuable for pediatricians in diagnosing HSPN in the high-risk population.

关键词： nephritis Tripterygium al.

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Combination therapy of Tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis

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Chinese Herbal Medicines 2019年第2期11卷 222-230页

作者： Wan-chun Ye Jian-zhong Ye Cheng Zheng Xiao-wei He Jia-jie Huang Ren Ye Department of Chemotherapy 2 Wenzhou Central Hospital Wenzhou 325000 China State Key Laboratory for Diagnosis and Treatment of Infectious Disease The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310000 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Hangzhou 310000 China Department of Cardiology The Second Affiliated Hospital Wenzhou Medical University Wenzhou 325000 China Zhuang Medical College Guangxi University of Chinese Medicine Nanning 530000 China Department of Traditional Chinese Medicine The First Affiliated Hospital Wenzhou Medical University Wenzhou 325000 China

Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,Tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager(version 5.2) and Stata(version 12.0).Results: A total of 12 randomized controlled trials(RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35,95% CI(1.22, 1.50), P 0.05), blood urea nitrogen [MD = 0.25, 95% CI(-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate[MD =-0.43, 95% CI(-3.48, 2.62), P > 0.05]. However, Tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI(1.34, 8.66), P Tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed.

关键词： diabetic nephropathy meta-analysis Tripterygium glycosides valsartan

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Role of oxidative stress in anti-cancer activity of Tripterygium wilfordii

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Traditional Medicine Research 2021年第6期6卷 3-7页

作者： Li-Ping Yang Jian Hao Dan Chen Department of Pharmacy Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application(Beijing Hospital)Beijing 100730China TMR Publishing Group Auckland 2014New Zealand

Introduction Oxidative stress,a characteristic of tumor cells,is defined as a relative excess of reactive oxygen species(ROS),directly associated with cancer.Although excessive ROS can cause oxidative damage,ROS within a certain threshold range can play an important second messenger function and participate in regulating important signaling pathways in cells,including induction of autophagy and apoptosis.Research has shown that acute and high ROS concentrations can damage DNA and induce cell apoptosis,whereas moderate ROS concentrations can induce temporary or permanent cell cycle arrest and cell differentiation.

关键词： damage Tripterygium acute

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Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schönlein purpura nephritis in children

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世界儿科杂志:英文版 2016年第3期12卷 376-379页

作者： Yan-Jie Huang Xiao-Qing Yang Wen-Sheng Zhai Xian-Qing Ren Yuan Sun Ying Ding The First Affiliated Hospital of Henan University of Traditional Chinese Medicine 19 Renmin road Zhengzhou 450000China

Our retrospective study was aimed to define the clinical manifestations,pathological features and prognosis of children with grade VI HSPN,our results also showed that Tripterygium glycosides(T glycosides)alone or com... 详细信息

关键词： protective nephritis Tripterygium

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Effects of Tripterygium wilfordii combined with viaminate capsules on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB

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Journal of Hainan Medical University 2018年第17期24卷 77-81页

作者： Ting Liu Yun-Zhu Mou Yan Liu Li Wang Department of Dermatology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000SichuanChina

Objective: To explore the effects of Tripterygium wilfordii combined with viaminate on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB. Methods: A total of 112 patients with psoriasis admitted in our hospital from September 2015 to November 2017 were randomly divided into control group (n=56) and observation group (n=56). The control group was treated only by Viaminate Capsules, and the observation group was treated with Tripterygium wilfordii tablet on the basis of the control group, the immune function, endothelial, inflammatory response, soluble intercellular adhesion molecules-1 (sICAM-1) and nuclear transcription factor-kB (NF-kB) expression levels were compared before and after treatment in the two groups. Results: Before treatment, CD4+, CD8+, CD4+/CD8+, vascular endothelial growth factor (VEGF), nitric oxide (NO), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), NF-kB, and sICAM-1 in two groups were no significant difference. After treatment, CD4+and CD4+/CD8+in both groups were significantly increased, while CD8+was significantly lower than before treatment, the CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group, and CD8+was obviously lower than that of the control group;The VEGF, NO and ET-1 in both groups were dramatically lower than those before treatment, and the VEGF, NO and ET-1 in the observation group were significantly lower than those in the control group;The TNF-α and IFN-γ in two groups were significantly lower than before treatment, and TNF-α and IFN-γ in the observation group were remarkably lower than those in the control group;The NF-kB and sICAM-1 in two groups were obviously decreased than those before treatment, and the NF-kB and sICAM-1 in the observation group were significantly lower than those in the control group. Conclusion: Tripterygium wilfordii combined with viaminate capsules in the treatment of psoriasis patients, can effectively correct their immune dysfunct

关键词： Tripterygium wilfordii Viaminate capsules Psoriasis Immune Endothelium Inflammatory reaction SICAM-1 NF-Kb

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