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SYNTHESIS OF (~3H-METHYL) trinitrotoluene AND ITS APPLICATION TO TOXICOLOGICAL STUDY

Nuclear Science and Techniques 1991年第1期2卷 60-64页

作者：张年宝俞斌伟秦锐芳谢炳华钟德松龚梓初顾秋萍金锡鹏王簃兰 Shanghai Institute of Nuclear Research Academia Sinica Shanghai 201800 China Department of Occupational Health Shanghai Medical University Shanghai 200032 China

In this paper, (2H- methyl) toluene was prepared by catalysed halogen- tritium substitution method from benzyl bromide, then it was nitrated to produce (8H- methyl) trinitrotoluene. The tritiated product was purified by thin- layer chromatography. At last, the pure 3H- TNT was obtained with specific radioactivity of 3.77 GBq/mmol. Radiochemical purity was over 98% and the ultraviolet absorption spectrum of tritiated TNT was conformed with that of standard sample. Using 3H- TNT as a tracer, its toxicokinetics was sudied in rats. The results showed that the toxicokinetics characteristics of TNT were quickly absorbed into the blood, Vd>2L/kg.h, long T1/2β and fixed accumulation with four routes of administration, TNT and its metabolites were mainly excreted by the urine. The half- life of TNT in the urine were 1,1- 24h. A trace of radioactivity of 3H- TNT and its metabolites could be detected in the urine on 7th day after administration (9.25×106Bq/kg).

关键词： (3H- methyl) toluene trinitrotoluene Catalysed halogen- tritium substitution method Toxicology Toxicokinetics

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A study on the genetic noxiousness of trinitrotoluene

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Journal of Forestry Research 1999年第2期10卷 115-117页

作者：徐来祥张建民刘国世

In this paper, the mutagencity of TNT was studied for mice and fruit flies. It was indicated that TNT had a great deal of mutagenic effect on the somatic ce1ls and sexual cells of the animals used as the subjects of t... 详细信息

关键词： trinitrotoluene Mouse Fruit fly Chromosomal aberration Sex linkage recessive lethal

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Using unmodified Au nanoparticles as colorimetric probes for TNT based on their competitive reactions with melamine

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Chinese Chemical Letters 2014年第9期25卷 1271-1274页

作者： Xiao-Dong Xia Hao-Wen Huang Key Laboratory of Theoretical Chemistry and Molecular Simulation Minister of EducationSchool of Chemistry and Chemical EngineeringHunan University of Science and Technology

Gold nanoparticles （Au NPs） can serve as visualized colorimetric probes for various targets and modification-free sensing strategies are preferred. The donor-acceptor interaction between the electron-rich melamine （MA） and the electron-deficient trinitrotoluene （TNT） allows formation of a supramolecule in aqueous solution. Melamine alone makes the initially individual reddish Au NPs aggregate into gray/blue Au NP assemblies due to melamine forming multiple ligand sites toward the Au NPs. Interestingly, the preformed supramolecule of MA-TNT disenables aggregation of the Au NPs. Therefore the unmodified Au NPs provide facile colorimetric probes for TNT detection in aqueous solution. Rapid identification of TNT is established by naked eye inspection. By using spectrophotometer tools, quantification of TNT is accomplished with a linear range of 80μmol L-1 to 1.2 mmol/L-1 and a limit of detection （LOD） of 27μmol/L^-1. In contrast to previous strategy with surface-modified Au NPs, here a modification-free sensing strategy for TNT assay has been developed with greater convenience, rapidity, and cost-effectiveness.

关键词： Electron donor-acceptor interaction Gold nanoparticles Melamine trinitrotoluene Colorirnetry

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