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trigonella foenum-graecum seeds extract plays a beneficial role on brain antioxidant and oxidative status in alloxan-induced Wistar rats

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Food Quality and Safety 2020年第2期4卷 83-89页

作者： Jangampalli Adi Pradeepkiran Venkata Subbaiah Nandyala Matcha Bhaskar Department of Zoology Division of Animal BiotechnologySri Venkateswara UniversityTirupatiIndia Department of Internal Medicine Texas Tech University of Health Science CentreLubbockUSA

Context:trigonella foenum-graecum(TriFG)exhibits increased scavenger enzymatic activities and reduces the production of reactive oxygen species in diabetic ***:The present study was aimed to investigate the effect of TriFG on lipid peroxidation levels and antioxidant status in brain tissue of rats exposed to *** and Methods:Healthy male rats(180±10 g)were allocated into five *** in group 1 maintained on normal tap water served as controls and rats in groups 2,3,4,and 5 were treated as experimental *** in group 2 were intraperitoneally injected with alloxan(120 mg/kg BW)and treated as diabetic rats,whereas rats in groups 3 and 4 were maintained on same experimental regimen as that of rats in groups 1 and 2,respectively,and in addition,they were orally gavaged with herbal extracts of TriFG(0.25 g/kg BW).Diabetic rats treated with glibenclamide in group 5 were used as positive *** and Discussion:Significant(P<0.001)increase in the antioxidant enzymes with a significant(P<0.001)decrease in the lipid peroxidation levels were observed in the brain tissue of diabetic rats treated with TriFG extract as compared to diabetic and glibenclamide-treated *** significant changes were observed in pro-and antioxidant levels in brain tissue of rats treated with TriFG extract alone when compared to normal *** diabetic rats,brain mitochondrial and cytosolic enzymes like succinate dehydrogenase,glutamate dehydrogenase,and glucose-6-phosphate dehydrogenase activity levels were significantly(P<0.05)decreased with reversely increased was observed in lactate dehydrogenase activity(P<0.05).Conclusions:The findings of the present study suggested that TriFG,through its antioxidant properties,protects brain tissue by mitigating oxidative stress induced by alloxan-exposed *** extract significantly increased the antioxidant and oxidative properties in diabetic rats when compared with the control group rats.

关键词： trigonella foenum-graecum hyperglycaemia brain antioxidants rats

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Ameliorative properties of Iranian trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 234-239页

作者： Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban Department of Biochemistry College of MedicineHa'il UniversityHa'ilSaudi Arabia Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Department of Pharmacology College of MedicineHa'il UniversityHa'ilSaudi Arabia

Objective: To assess the ameliorative properties of Iranian trigonella foenum-graecum L.(T. foenum-graecum) seeds and Punica granatum L.(P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea ***: Sixty guinea pigs were divided into six groups(10 guinea pigs per group).Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, *** animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were ***: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters(blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters ***: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

关键词： Diabetes Iranian trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin

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Antioxidant,phytotoxic and cytotoxic activity of methanolic extract of trigonella foenum-graecum

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Journal of Coastal Life Medicine 2016年第5期4卷 386-389页

作者： Amin Ullah Said Hassan Muhammad Imran Khan Muhammad Rizwan Zafar Ullah Mukaram Shah Center of Biotechnology and Microbiology University of PeshawarPeshawar KPPakistan Department of Biotechnology University of Science and TechnologyBannuKhyber PakhtunkhawaPakistan Agriculture Research Institute Tarnab Farm PeshawarKhyber PakhtunkhawaPakistan

Objective:To analyze the methanol extract of trigonella foenum-graecum(***-graecum)for antioxidant,phytotoxic and cytotoxic ***:The powder of ***-graecum was extracted in diluted methanol with the help of random shaking *** extracts of the plant were measured for cytotoxic activity(beside brine shrimp and antioxidant activity vs.1,1-diphenyl-2-picrylhydrazyl free radical).Results:Various concentrations of methanolic extract of ***-graecum were observed as 36.16%to 54.12%with rising concentrations of 50 to 1000μg/*** phytotoxic activity(100 and 1000μg/mL)reduced the growth of roots(radicals)and shoots(hypocotyls)of rice when compared to control after 3 and 7 days’*** a concentration of 10μg/mL,the survival rate of cytotoxic activity of brine shrimp was maximum and at a concentration of 250μg/mL,the death rate of brine shrimp was ***:***-graecum has potential activity against free radical mediated sickness and thus it is possible to treat cancer.

关键词： 1,1-Diphenyl-2-picrylhydrazyl Cytotoxic Antioxidant trigonella foenum-graecum Free radicals

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