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Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage

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Neural Regeneration Research 2014年第22期9卷 1985-1994页

作者： Yifan He Jihong Zhu Fang Huang Liu Qin Wenguo Fan Hongwen He Guanghua School of Stomatology Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Stomatology Huaihe Hospital Henan University

The tooth belongs to the trigeminal sensory pathway. Dental damage has been associated with impairments in the central nervous system that may be mediated by injury to the trigeminal nerve. In the present study, we investigated the effects of damage to the inferior alveolar nerve, an important peripheral nerve in the trigeminal sensory pathway, on learning and memory be-haviors and structural changes in related brain regions, in a mouse model of Alzheimer’s disease. Inferior alveolar nerve transection or sham surgery was performed in middle-aged （4-month-old） or elderly （7-month-old） senescence-accelerated mouse prone 8 （SAMP8） mice. When the middle-aged mice reached 8 months （middle-aged group 1） or 11 months （middle-aged group 2）, and the elderly group reached 11 months, step-down passive avoidance and Y-maze tests of learn-ing and memory were performed, and the cholinergic system was examined in the hippocampus （Nissl staining and acetylcholinesterase histochemistry） and basal forebrain （choline acetyltrans-ferase immunohistochemistry）. In the elderly group, animals that underwent nerve transection had fewer pyramidal neurons in the hippocampal CA1 and CA3 regions, fewer cholinergic ifbers in the CA1 and dentate gyrus, and fewer cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band, compared with sham-operated animals, as well as showing impairments in learning and memory. Conversely, no signiifcant differences in histology or be-havior were observed between middle-aged group 1 or group 2 transected mice and age-matched sham-operated mice. The present ifndings suggest that trigeminal nerve damage in old age, but not middle age, can induce degeneration of the septal-hippocampal cholinergic system and loss of hippocampal pyramidal neurons, and ultimately impair learning ability. Our results highlight the importance of active treatment of trigeminal nerve damage in elderly patients and those with Alzheimer’s disease, and indicate th

关键词： nerve regeneration Alzheimer' s disease trigeminal nerve learning memory hippocampal CA1 hippocampal CA3 dentate gyrus basal forebrain medial septal nucleus vertical limb of the diagonal band cholinergic neurons cholinergic fibers pyramidal cells NSFC grants neural regeneration

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Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone

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Neural Regeneration Research 2023年第6期18卷 1364-1370页

作者： Madeha Ishag Adam Ling Lin Amir Mahmoud Makin Xiao-Fen Zhang Lu-Xi Zhou Xin-Yue Liao Li Zhao Feng Wang Dao-Shu Luo Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Laboratory of Clinical Applied AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Public Technology Service Center of Fujian Medical University FuzhouFujian ProvinceChina Center for Membrane and Water Science&Technology Institute of Oceanic and Environmental Chemical EngineeringZhejiang University of TechnologyHangzhouZhejiang ProvinceChina

The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central *** special anatomical and physiological structure renders it susceptible to nerve *** etiology of most primary trigeminal neuralgia is closely related to microvascular compression of the trigeminal root entry *** study aimed to develop an efficient in vitro model mimicking the glial environment of trigeminal root entry zone as a tool to investigate the effects of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor on the structural and functional integrity of trigeminal root entry zone and modulation of cellular *** astrocytes and Schwann cells isolated from trigeminal root entry zone of postnatal rats were inoculated into a two-well silicon culture insert to mimic the trigeminal root entry zone microenvironment and treated with glial cell line-derived neurotrophic factor and brain-derived neurotrophic *** monoculture,glial cell line-derived neurotrophic factor promoted the migration of Schwann cells,but it did not have effects on the migration of *** the co-culture system,glial cell line-derived neurotrophic factor promoted the bidirectional migration of astrocytes and Schwann ***-derived neurotrophic factor markedly promoted the activation and migration of ***,in the co-culture system,brain-derived neurotrophic factor inhibited the migration of astrocytes and Schwann cells to a certain *** findings suggest that glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor are involved in the regulation of the astrocyte-Schwann cell interaction in the co-culture system derived from the trigeminal root entry *** system can be used as a cell model to study the mechanism of glial dysregulation associated with trigeminal nerve injury and possible therapeutic interventions.

关键词： astrocytes brain-derived neurotrophic factor cell migration glial cell line-derived neurotrophic factor glial interaction Schwann cells trigeminal nerve

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trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa： a Case Report

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Chinese Medical Sciences Journal 2017年第2期32卷 123-128页

作者： TingWang LinMa Xin Lou BoBu Department of Radiology Department of neurosurgery Chinese PLA General Hospital Beijing 100853 China

GANGLIONEUROMA is considered as the most mature and noninvasive form of neuroblastic tumors. It derives from neural crest cells, and can arise from wherever sympathetic tissue exists, including neck, posterior mediastinum, adrenal gland, retroperitoneum and pelvis. The two most common locations for this tumor are retroperitoneum and posterior mediastinum; infrequently it occurs in the intracranial re-gion,2-8 with only three cases has been reported arising from trigeminal nerve.2-4 The current paper presents a 49-year-old male patient with a ganglioneuroma arising from right trigeminal ganglion and extending to the mid-dle-posterior cranial fossa. We summarized the clinical and diagnostic characteristics of this extremely rare tumor, in comparison with the three reported cases in literatures.

关键词： ganglioneuroma trigeminal nerve computed tomography magnetic resonance imaging middle-posterior cranial fossa

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Distant metastasis of hepatocellular carcinoma to Meckel’s cave and cranial nerves:A case report and review of literature

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World Journal of Hepatology 2021年第6期13卷 709-716页

作者： Soo Ki Kim Takako Fujii Ryouhei Komaki Hisato Kobayashi Toyokazu Okuda Yumi Fujii Takanobu Hayakumo Kanako Yuasa Masahiro Takami Aya Ohtani Yuka Saijo Yu-Ichiro Koma Soo Ryang Kim Department of Gastroenterology Kobe Asahi HospitalKobe 653-0801HyogoJapan Division of Neurology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan Department of Radiology Kobe Asahi HospitalKobe 653-0801HyogoJapan Department of Pharmacy Kobe Asahi HospitalKobe 653-0801HyogoJapan Department of Pathology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Metastasis occurs as a late event in the natural history of hepatocellular carcinoma(HCC),and most patients die of liver failure attributed to the tumor supplanting the ***,the brain is a less common metastatic *** SUMMARY We describe a rare case of hepatitis C virus-related multiple HCC metastasizing to the cavernous sinus,Meckel’s cave,and the petrous bone involving multiple cranial nerves in an 82-year-old *** admission imaging studies including Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(MRI)revealed multiple HCC nodules in both right and left *** guided biopsy of the left lobe revealed moderately differentiated *** targeted therapy with Lenvatinib(8 mg/d for 94 d,per os)and Ramucirumab(340 mg/d and 320 mg/d,two times by intravenous injection)were administered for 4 mo,resulting in progression of the *** months after the start of molecular target therapy,the patient presented with symptoms of hyperalgesia of the right face and limited abduction of the right eye,indicating disturbances in the right trigeminal and abducens *** MRI disclosed a mass involving the cavernous sinus,Meckel’s cave and the petrous ***-enhanced MRI with gadolinium-chelated contrast medium revealed a well-defined mass with abnormal enhancement around the right cavernous sinus and the right Meckel’s *** The diagnosis of metastatic HCC to the cavernous sinus,Meckel’s cave,and the petrous bone was made based on neurological findings and imaging studies including MRI,but not on histological *** studies may provide insights into various methods for diagnosing HCC metastasizing to the craniospinal area.

关键词： Meckel’s cave Abducens nerve trigeminal nerve Hepatocellular carcinoma Magnetic resonance imaging Case report

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Percutaneous microballoon compression for trigeminal neuralgia

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Chinese Medical Journal 2007年第3期120卷 228-230页

作者： LIU Hong-bing MA Yi ZOU Jian-jun LI Xin-gang Department of Neurosurgery Qilu Hospital Shandong UniversityJinan 250012 China Department of Neurosugery Liaoning Provincial HospitalShenyang 110001 China

Background Percutaneous microballoon compression （PMC） for trigeminal neuralgia is an important therapeutic method. The aim of this study was to review the effects of PMC for trigeminal neuralgia in 276 patients. Methods From December 2000 to May 2003, 276 patients with trigeminal neuralgia were treated with PMC. The course of the disease ranged from 3 months to 38 years. Under the guidance of C-arm X-ray, 14# needle was placed into the foramen ovale using the classical Hakanson＇s technique. Fogarty balloon catheter was navigated into the Meckel＇s cave tenderly. A small amount of Omnipaque was slowly injected to inflate the balloon and compress the trigeminal ganglion for 3 to10 minutes. Results A total of 290 PMC were performed on the 276 patients. Among them, 252 had immediate relief from pain. The patients were followed up for a mean of 18.7 months （range, 4 to 32）, 14 of them had a recurrence. Of the 14 patients, 12 were re-operated with PMC, and the pain was all controlled successfully. Conclusions PMC is an effective and technically simple method for trigeminal neuralgia. For older patients with trigeminal neuralgia, it may be the first choice.

关键词： trigeminal nerve trigeminal neuralgia percutaneous microballoon compression

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Two Cases of Severe Dementia Showing Dramatic Improvement after Denture Placement

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Advances in Alzheimer's Disease 2016年第2期5卷 46-52页

作者： Yoshiro Fujii Shin Kobe Dental Clinic Kobe City Japan

Severe dementia, including Alzheimer’s disease, is intractable and progressive. The purpose of this study was to document the improvement observed in two cases of severe dementia after denture placement. The subjects, two women in their 70s with severe dementia, were diagnosed with Alzheimer’s disease by the medical doctors in charge of their cases. In the first case, the subject’s symptoms included severe disorientation, impaired communication, and a tendency to wander. Two weeks after a lower complete denture placement, she was able to greet others. Five weeks later, she was able to communicate and precisely read an analog clock. Her condition continued to improve for at least 3 months. In the second case, the subject’s mouth was always open. She was bedridden in a vegetative state and hardly moved, talked, or laughed;it was impossible to communicate with her. Only a few seconds after an upper complete denture placement, she started to talk, albeit unintelligibly. Two weeks after a lower complete denture placement, she could communicate normally, laugh, and walk without help. Although the underlying mechanism has not yet been clarified, the author hypothesizes that positive signals from the oral area are transferred to the brain as positive stimulation via the trigeminal nerve, the largest cranial nerve.

关键词： Dementia Alzheimer’s Disease Complete Denture Dental Treatment trigeminal nerve

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Odontogenic Herpes Zoster Infection: A Case Report and Review

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Case Reports in Clinical Medicine 2022年第12期11卷 487-493页

作者： Edlira Maska Austin J. Trent Andrea de Lemos Larry M. Bush Department of Medicine Wellington Regional Medical Center Wellington FL USA Charles E. Schmidt College of Medicine Florida Atlantic University Boca Raton FL USA Department of Medical Education University of Miami-Miller School of Medicine Palm Beach County FL USA

Herpes zoster is a commonly encountered entity of which all clinicians should be aware. The diagnosis is most often considered and made based on a characteristic vesicular rash that presents in a unilateral dermatomal distribution and is usually accompanied by a painful neuritis. Not uncommonly, the pain presents a few days before the rash becomes evident and may even occur without the rash appearing. When this happens patients may be subject to further diagnostic testing seeking alternative diagnoses, as herpes zoster is known to mimic a variety of other non-cutaneous organ system entities. Although the thoracic and lumbar dermatomes are the affected most frequently, in approximately one-fifth of cases the cranial nerves are involved either singularly or in combination. trigeminal nerve zoster is of particular concern as it poses a risk of developing into zoster ophthalmicus with subsequent keratitis and uveitis resulting in permanent vision impairment. Involvement of the second (maxillary) and third (mandibular) branches of this 5th cranial nerve are less common and may present with signs and symptoms of a primary dental process. The infrequency and unfamiliarity of herpes zoster odontogenic manifestations can lead to unnecessary investigation and treatment. Apropos such a case we review the epidemiology, pathophysiology, signs, and symptoms of odontogenic herpes zoster.

关键词： Herpes Zoster trigeminal nerve Odontogenic

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