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Efficacy and safety of human chorionic gonadotropin combined with human menopausal gonadotropin and a gonadotropin-releasing hormone pump for male adolescents with congenital hypogonadotropic hypogonadism

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Chinese Medical Journal 2021年第10期134卷 1152-1159页

作者： Ying Liu Xiao-Ya Ren Ya-Guang Peng Shao-Ke Chen Xin-Ran Cheng Miao Qin Xiao-Ling Wang Yan-Ning Song Li-Jun Fan Chun-Xiu Gong Department of Pharmacy Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Endocrinology Genetics and MetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region NanningGuangxi 530003China Department of Endocrinology Chengdu Women’s and Children’s Central HospitalChengduSichuan 610091China Beijing Key Laboratory for Genetics of Birth Defects Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Background:Compared to adult studies,studies which involve the treatment of pediatric congenital hypogonadotropic hypogonadism(CHH)are limited and no universal treatment regimen is *** aim of this study was to evaluate the feasibility of human chorionic gonadotropin(hCG)/human menopausal gonadotropin(hMG)therapy for treating male adolescents with ***:Male adolescent CHH patients were treated with hCG/hMG(n=20)or a gonadotropin-releasing hormone(GnRH)pump(n=21).The treatment was divided into a study phase(0-3 months)and a follow-up phase(3-12 months).The testicular volume(TV),penile length(PL),penis diameter(PD),and sex hormone levels were compared between the two *** TV and other indicators between the groups were analyzed using a t-test(equal variance)or a rank sum test(unequal variance).Results:Before treatment,there was no statistical difference between the two groups in terms of the biochemistry,hormones,and other demographic *** 3 months of treatment,the TV of the hCG/hMG and GnRH groups increased to 5.1±2.3 mL and 4.1±1.8 mL,respectively;however,the difference was not statistically significant(P>0.05,t=1.394).The PL reached 6.9±1.8 cm and 5.1±1.6 cm(Ptreatment,biomarkers were in normal range in the two *** with the GnRH group,the testosterone(T)level and growth of PL and PD were significantly greater in the hCG/hMG group(all P0.05,t=0.314).After 9 to 12 months of treatment,the T level was higher in the hCG/hMG *** parameters did not exhibit a statistical ***:The hCG/hMG regimen is feasible and effective for treating male adolescents with *** initial 3 months of treatment may be a window to optimally observe the strongest effects of ***,results

关键词： Congenital hypogonadotropic hypogonadism Gonadotropin-releasing hormone Human chorionic gonadotropin Human menopausal gonadotropin treatment regime

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