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Cutaneous Manifestations and treatment advances of Adult T-Cell Leukemia/Lymphoma

International Journal of Dermatology and Venereology 2022年第1期5卷 40-44页

作者： Ying Zhang Hao Chen Jian-Fang Sun Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Adult T-cell leukemia/lymphoma(ATLL)is an aggressive peripheral T-cell lymphoma caused by the human T lymphotropic virus *** skin is affected in approximately half of ATLL patients,and skin lesions may be the first manifestation of the *** skin lesions of ATLL are polymorphous,and depend on the type of skin eruption,which makes it possible for doctors to predict the prognosis of the disease based on the characteristics of skin *** this review article,we describe the clinical manifestations and histopathological patterns of skin lesions in ATLL,focus on its diagnostic and prognostic significance,and also summarize the advances in the treatment of ATLL.

关键词： adult T cell leukemia/lymphoma(ALL) cutaneous treatment advances

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Pancreatic cancer: advances in treatment

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World Journal of Gastroenterology 2014年第28期20卷 9354-9360页

作者： Somala Mohammed George Van Buren Ⅱ William E Fisher The Elkins Pancreas Center Michael E DeBakey Department of Surgeryand Dan L Duncan Cancer CenterBaylor College of Medicine

Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is expected to continue *** patients with pancreatic cancer have traditionally faced a dismal prognosis,over the past several years various advances in diagnosis and treatment have begun to positively impact this *** of effective combinations of existing chemotherapeutic agents,such as the FOLFIRINOX and the gemcitabine+nab-paclitaxel regimen,has improved survival for selected patients although concerns regarding their toxicity profiles remain.A better understanding of pancreatic carcinogenesis has identified several pre-malignant precursor lesions,such as pancreatic intraepithelial neoplasias,intraductal papillary mucinous neoplasms,and cystic *** technology has also evolved dramatically so as to allow early detection of these lesions and thereby facilitate earlier *** remains a cornerstone of treatment for patients with resectable pancreatic tumors,and advances in surgical technique have allowed patients to undergo resection with decreasing perioperative morbidity and *** has also become feasible in selected patients with borderline resectable tumors as a result of neoadjuvant ***,pancreatectomy involving vascular reconstruction and pancreatectomy with minimally invasive techniques have demonstrated safety without significantly compromising oncologic ***,a deeper understanding of molecular aberrations contributing to the development of pancreatic cancer shows promise for future development of more targeted and safe therapeutic agents.

关键词： Pancreatic cancer Pancreaticoduodenectomy treatment advances Pancreatic oncology Chemotherapy FOLFIRINOX Pancreatic resection

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