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treatment outcome,cognitive function,and psychopathology in methamphetamine users compared to other substance users

World Journal of Psychiatry 2022年第7期12卷 944-957页

作者： Nina Behle Felicia Kamp Lisa Proebstl Laura Hager Marlies Riebschläger Maik Schacht-Jablonowsky Willem Hamdorf Stefanie Neumann Daniela Krause Kirsi Manz Andreas Guenter Franke Gabriele Koller Michael Soyka Department of Psychiatry and Psychotherapy Ludwig Maximilians UniversityMunich 80336Germany MEDIAN Clinic MecklenburgVitense 19217Germany Institute for Medical Information Processing Ludwig Maximilians UniversityMunich 81377Germany University of Applied Labour Studies of the Federal Employment Agency Mannheim 68163Germany Department of Psychiatry Ludwig Maximilians UniversityMunich 80336Germany

BACKGROUND The rising number of people using methamphetamine leads to an increasing need for treatment options for this patient ***-based research on the efficacy of treatment programs for methamphetamine users is *** to specific characteristics of methamphetamine users,the question arises whether established treatment methods for individuals using other substances can be effective for the treatment of methamphetamine dependence as *** hypothesize that there are significant differences between the two groups that may affect the effectiveness of treatment and worsen the prognosis of treatment outcomes for methamphetamine users compared to consumers of other *** To investigate potential differences in cognitive functioning and psychopathology between methamphetamine users and other substance users and possible correlations with treatment *** A total of 110 subjects were recruited for an observational,longitudinal study from a German inpatient addiction treatment center:55 patients with methamphetamine dependence and 55 patients with dependence of other substances(“OS group”).Both groups were examined at beginning(baseline)and end of treatment(after 6 mo)with regard to treatment retention,craving,cognitive functioning,psychosocial resources,personality traits,depression,and other psychiatric *** used were Raven’s IQ test,Mannheimer craving scale,cognitrone cognitive test battery,NEO personality factors inventory,Hamilton depression scale,Becks depression inventory,and a symptom *** statistical methods used were χ^(2)-test,t-test and multiple mixed *** A total drop-out rate of 40%(methamphetamine-group:36.4%;OS-group:43.6%)was observed without significant differences between *** baseline,methamphetamine-group subjects significantly differed from OS-group individuals in terms of a lower intelligence quotient,fewer years of education,slower working speed,and decreased working accura

关键词： treatment outcome Cognitive function Psychopathology Methamphetamine Substance use Comparison

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treatment outcome in children with central nervous system-positive Burkitt lymphoma using only intrathecal and systemic chemotherapy combined with rituximab

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Chinese Medical Journal 2021年第11期134卷 1329-1334页

作者： Shuang Huang Lin Jin Jing Yang Yan-Long Duan Meng Zhang Chun-Ju Zhou Yong-Hong Zhang Beijing Key Laboratory of Pediatric Haematology Oncology National Discipline of PediatricsMinistry of EducationMOE Key Laboratory of Major Diseases in ChildrenHaematology Oncology CenterBeijing Children’s HospitalBeijing 100045China Pathology Department Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Background:With current chemotherapy treatment,>90%of survival has been obtained for Burkitt lymphoma(BL).In this study,the demographic characteristics and treatment outcomes are presented for 78 children in China with central nervous system-positive(CNS+)***:This retrospective study consecutively enrolled 78 CNS+BL patients in Beijing Children’s Hospital(BCH)from 2007 to 2019 who received the BCH B-cell non-Hodgkin’s lymphoma regimen(modified by French-American-British mature lymphoma B-cell 96[FAB/LMB96]C1 arm±rituximab).Clinical characteristics,methods of disease detection in the CNS,and outcomes were *** and multivariate analyses were used to assess prognostic ***:The median age of 65 boys and 13 girls at the time of diagnosis was 5.7 years(ranging from 1 to 14 years).Patients were followed up for a median time of 34 months(ranging from 1 to 72 months).Bone marrow invasion was found in 38(48.7%)*** were 48(61.5%),44(56.4%),and 25(32%)patients with cranial nerve palsy,intracerebral mass(ICM),and parameningeal extension,*** cerebrospinal fluid(CSF)morphology and CSF immunophenotype appeared in 15(19.2%)and 15(19.2%)patients,*** were 69(88.5%)patients treated with chemotherapy combined with rituximab,and nine patients were treated solely with ***,five patients died of treatment-related infection,recurrence occurred for 13,and one developed a second *** 3-year overall survival and event-free survival rates were 78.9%±4.7%and 71.4%±6.0%,*** with chemotherapy only,ICM positivity,and>4 organs involved at diagnosis were independent risk ***:Rituximab combined with a modified LMB96 regimen has greatly increased the efficacy of treatment for Chinese children with CNS+BL,and with the continuous collection of outcome data,treatment-related complications are *** further verification,a large sample multicentre randomized controll

关键词： Burkitt lymphoma Central nervous system disease Rituximab treatment outcome

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Study on Effect of Anxious Emotion of the Female Who Enter IVF-ET treatment Cycle on treatment outcome

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Journal of Reproduction and Contraception 2009年第4期20卷 211-216页

作者： Xiao-yu YANG Yun-shan ZHANG Di LU Ming QIAN Nursing Department Tianjin Medical College Tianjin 300222 China Center for Reproductive Medicine Tianjin Central Hospital for Obstetrics & Gynecology Tianjin 300052 China Department of Medicial Psychology Tianjin Medical University Tianjin 300070 China

Objective To detect effect of anxious emotion of the female who enter IVF-ET treatment cycle on treatment outcome.Methods Ninety infertilio, women who joined in IVF-ET treatment were collected and they were tested with the State-Trait Anxiety Form at the day entering treatment cycle, with State Anxiety Form at 1 h before oocyte retrieval and 12 d after ET waiting for blood β-hCG result.Results The average of trait anxiety score （38.5） was used to divide patients into two groups. There were significant differences in state anxiety at the first and second test points between high score group （39.9 ± 7.8, 41.5 ± 11.2） and low score group （33.1 ±6.9, 33.7 ±8.1）, but there was no difference at the third point. At three test points, the changes of state anxiety in high-trait anxiety score group showed no difference, but in low-trait anxiety score group there was higher level at the third point than at the first point （38.4 ± 10.6 vs 32.7 ±7.4）（P〈0.05）. Compared variables of psychology, the results demonstrated that trait anxiety, score of success group （β-hCG〉 25 IU/L 12 d after IVF-ET） was higher than that of failure group （40.9 ± 9.2 vs 36.8 ± 7.6）（P〈0.05）.Conclusion Trait anxiety, may be one of mental influential factors on treatment outcome.

关键词： IVF-ET state anxiety trait anxiety treatment outcome

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High-frequency oscillations detected by electroencephalography as biomarkers to evaluate treatment outcome,mirror pathological severity and predict susceptibility to epilepsy

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Acta Epileptologica 2021年第1期3卷 205-213页

作者： Yueqian Sun Guoping Ren Jiechuan Ren Qun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Institute of Brain Disorders Collaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijingChina Beijing Key Laboratory of Neuromodulation BeijingChina

High-frequency oscillations(HFOs)in the electroencephalography(EEG)have been extensively investigated as a potential biomarker of epileptogenic *** understanding of the role of HFOs in epilepsy has been advanced considerably over the past decade,and the use of scalp EEG facilitates recordings of *** were initially applied in large scale in epilepsy surgery and are now being utilized in other *** this review,we summarize applications of HFOs in 3 subtopics:(1)HFOs as biomarkers to evaluate epilepsy treatment outcome;(2)HFOs as biomarkers to measure seizure propensity;(3)HFOs as biomarkers to reflect the pathological severity of ***,knowledge regarding the above clinical applications of HFOs remains limited at *** validation through prospective studies is required for its reliable application in the clinical management of individual epileptic patients.

关键词： High-frequency oscillations Epilepsy Electroencephalography treatment outcome Seizure prediction Pathology

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Assessment of Contributions of Community Tuberculosis Intervention to Tuberculosis Case Detection and treatment outcome in Two States in Nigeria

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Journal of Tuberculosis Research 2020年第3期8卷 136-147页

作者： Audu Onyemocho Hassan Abiodun Queen Ogbuji Adewale Osho Shember-Agela Igbabul Gajere Julius Omole Victoria Nanben Anejo-Okopi Joseph Department of Epidemiology and Community Health College of Health Sciences Benue State University Makurdi Benue State Nigeria Association for Reproductive and Family Health Abuja Nigeria Benue State Epidemiology and Disease Control Unit Makurdi Benue State Nigeria Ministry of Health Kaduna state Kaduna Nigeria Department of Community Medicine College of Medicine Kaduna State University Kaduna Nigeria Department of Microbiology Faculty of Natural Sciences University of Jos Plateau State Nigeria

Background: Nigeria, one of the high burden Tuberculosis countries, has developed various intervention strategies to ensuring universal access to quality-assured tuberculosis diagnosis and treatment. However, low case detection and unsuccessful treatment outcome still remains a serious challenge in most states. Community Tuberculosis care was born against this background in 2010 as a complementing front to combat the challenges, bringing directly observed treatment short-course strategy beyond the clinic settings to the door steps of patients. This study evaluates the contributions of the intervention to Tuberculosis case detection and treatment outcomes in two states in Nigeria. Materials and Method: A retrospective study with multistage sampling technique was employed to review 23,241 presumptive Tuberculosis cases enrolled for management between 2014-2017. Chi-square (χ2) test was used for test of association between the independent variables and the main outcomes of the study, with statistical significance set at p-value of 5%. Results: The annual percentage increase for both states was 24.7%, 189.8% and 114.5% in the study group as against 5.2%, 44.6% and 65.6% in control group. Overall, 23.8% were bacteriologically positive (either AFB or Gene-Xpert MTB/Rif) and 1.4% were clinically evaluated to be positive, while 74.8% were bacteriologically negative. Of the total 5861 cases treated, successful treatment rate of the patients in the study group was 88.6% as compared to 76.1% in the control group. The relationship between the referral system from communities where the intervention program was implemented and the case detection/treatment outcome was statistically significant (OR 95% CI = 3.15, 2.95 - 3.35). Conclusion: The community level Tuberculosis intervention led to significantly better case detection and treatment outcome when c

关键词： Case Detection Community Care Contribution Tuberculosis treatment outcome

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Root Canal treatment outcome and Restorative Condition of Teeth Treated by Undergraduates—A Clinical and Radiographic Evaluation

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Open Journal of Stomatology 2023年第9期13卷 257-270页

作者： Gabriela Tonet Bassani Bartelle Dianeia Miranda dos Reis Thiago Oliveira Gamba Fabiana Vieira Vier-Pelisser School of Dentistry UCS—Caxias do Sul University Caxias do Sul Brazil School of Dentistry UFRGS—Federal University of Rio Grande do Sul Porto Alegre Brazil

Background: The aim was to evaluate the nonsurgical Root Canal treatment (nRCT) outcome, the restorative condition and the relationship between the coronal restoration quality and the outcome of teeth endodontic treated by undergraduates at the University of Caxias do Sul School of Dentistry (UCS-SD), Brazil, between 2019 and 2021. Materials and Methods: Data from the endodontically treated cases were retrieved, and the patients were recalled for a follow-up appointment at the university. The endodontic diagnosis, radiographs, and the presence of definitive restorations were analyzed in the clinical records. During the follow-up appointment, endodontically treated teeth were classified as present or absent. The nRCT was classified as successful (complete or incomplete healing) or failure (uncertain or unsatisfactory healing). Coronal restoration was classified as absent or present. When it was present, it was classified as permanent or temporary, and its quality as adequate or inadequate restoration. The results were presented as percentages. Results: A total of 257 teeth were endodontically treated. The most prevalent diagnosis was Chronic Apical Periodontitis (33.33%) and the most commonly treated teeth were premolars (46.15%). A total of 52 (21%) treated teeth were clinically and radiographically reexamined. The success rate for the nRCT was 98.08%. About 61.54% of this sample had a definitive composite resin restoration. Conclusion: The nRCT success rate was high. Special attention should be given to the presence and quality of the definitive restoration. Clinical Implications: There was no statistically significant impact between the coronal restoration and the nRCT success (P > 0.05).

关键词： Periapical Periodontitis Permanent Dental Restoration Permanent Dental Filling Root Canal Obturation treatment outcome

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Effect of nonoperative treatment on the outcome of patients with posttraumatic hydrocephalus

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中华创伤杂志(英文版) 2002年第1期5卷 8-12页

作者：伏林山汤云海王世余 Department of Neurosurgery The Fourth Affiliated Hospital of Nantong Medical College The First People's Hospital of Yancheng Yancheng 224001 China

Objective: To compare the outcome of non-operative treatment with the outcome of surgical intraventricular drainage for patients with posttraumatic hydrocephalus including complications, mortality and favorable outcome. Methods: Thirty-nine patients were assigned to a nonoperative treatment group and 38 patents to a surgical intraventricular drainage group. Each patient’s outcome was evaluated 3 years after treatment by using Glasgow outcome Scale. Results: In the nonoperative treatment group the rate of favorable outcome (good recovery or mild disability) was 89.74% (35 of 39 patients) and the mortality was 2.56% (1 of 39 patients). In the surgical intraventricular drainage group the rate of favorable outcome was 71.05% (27 of 38 patients) and the mortality was 13.16% (5 of 38 patients; Ptreatment may be better than surgical intraventricular drainage for patients with posttraumatic hydrocephalus.

关键词： Hydrocephalus Wounds and injuries treatment outcome Nonoperative therapy

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treatment outcomes of tuberculosis patients under directly observed treatment short-course at Debre Tabor General Hospital,northwest Ethiopia:nine-years retrospective study

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Infectious Diseases of Poverty 2018年第1期7卷 172-178页

作者： Seble Worku Awoke Derbie Daniel Mekonnen Fantahun Biadglegne Department of Medical Laboratory Sciences College of Health SciencesDebre Tabor UniversityDebre TaborEthiopia Department of Medical Microbiology Immunology and ParasitologyCollege of Medicine and Health SciencesBahir Dar UniversityP.O.Box 1383Bahir DarEthiopia Biotechnology Research Institute Bahir Dar UniversityBahir DarEthiopia

Background:Data regarding tuberculosis(TB)treatment outcomes,proportion of TB/HIV co-infection and associated factors have been released at different TB treatment facilities in Ethiopia and elsewhere in the world as part of the auditing and surveillance ***,these data are missing for the TB clinic offering directly observed treatment short-course(DOTs)at Debre Tabor General Hospital(DTGH).Methods:The authors analysed the records of 985 TB patients registered at the DTGH from September 2008 to December *** on patients’sex,age,type of TB,and treatment outcomes were extracted from the TB treatment registration *** treatment outcome of patients was categorized according to the National TB and Leprosy Control Program guidelines:cured,treatment completed,treatment failed,died,and not evaluated(transferred out and unknown cases).Results:Around half of the registered patients were males(516,52.4%).In terms of TB types,381(38.7%),241(24.5%),and 363(36.9%)patients had smear-negative pulmonary TB,smear-positive pulmonary TB,and extra pulmonary TB,*** hundred and seventy-two patients(90.1%)had successful treatment outcomes(cured and treatment completed),while 74 patients(9.9%)had unsuccessful treatment outcomes(death and treatment failure).TB treatment outcome was not associated with age,sex,type and history of TB,or co-infection with HIV(P>0.05).The proportion of TB/HIV co-infection was at 24.2%,and these were found to be significantly associated with the age groups of 25-34,35-44 and≥65 years:(aOR:0.44;95%CI:0.25-0.8),(aOR:0.39;95%CI:0.20-0.70),(aOR:4.2;95%CI:1.30-12.9),***:The proportion of patients with successful treatment outcomes was above the World Health Organization target set for Millennium Development Goal of 85%and in line with that of the global milestone target set at>90%for *** higher proportions of transfer-out cases were recorded in the present ***,the proportion of TB/HIV co-i

关键词： Tuberculosis treatment outcome DOTS Debre Tabor General Hospital Ethiopia

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and treatment outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age treatment outcome

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Assessing the impact of TB/HIV services integration on TB treatment outcomes and their relevance in TB/HIV monitoring in Ghana

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Infectious Diseases of Poverty 2012年第1期1卷 110-117页

作者： Gloria Akosua Ansa John D Walley Kamran Siddiqi Xiaolin Wei University Hospital LegonUniversity of GhanaP.O.Box LG 79LegonAccraGhana Nuffield Centre for International Health and Development University of Leeds101 Clarendon RoadLeeds LS29LJUnited Kingdom Department of Health Sciences The University of YorkSeebohm Rowntree BuildingHeslingtonYork YO105DDUnited Kingdom School of Public Health and Primary Care Chinese University of Hong KongHong KongChina

Background:The impact of the human immunodeficiency virus(HIV)on tuberculosis(TB),and the implications for TB and HIV control,is a public health challenge in Ghana-almost a quarter(23%)of all TB cases were HIV positive in *** integration of TB/HIV services has therefore emerged as an essential component of the national response to TB and *** aim is to reduce fragmentation,improve access,enhance efficiency and improve quality of ***’s TB/HIV policy comprises three linked sets of activities:effective implementation of the Stop TB Strategy for TB control,improved HIV prevention and care,and the implementation of additional TB/HIV *** models of service delivery with increasing integration of TB/HIV activities are expected to provide greater access to more comprehensive *** objective of this paper is to assess the impact of TB/HIV integration on TB treatment outcomes and to explore the usefulness of TB treatment outcomes as TB/HIV ***:A before-and-after study to observe the introduction of TB/HIV activities into TB programmes in three hospitals with different levels of integration was *** patient data was collated from TB registers from each facility,and analysed to determine if TB treatment outcomes changed significantly after ***:TB treatment success was 50%(95%CI 49-52)prior to,and 69%(95%CI 65-73)after,integration(Χ243.96,ptreatment success increased from 43%to 53%at the one-stop shop(OSS),from 69%to 78%at the partially integrated site(PIS)and substantially from 46%to 78%at the referral site(RS)(Χ264.54;ptreatment *** rates remained high at 18%in all cases studied and 25%in HIV-associated cases after ***:TB/HIV integration may improve TB treatment success,but its exact impa

关键词： Tuberculosis HIV Integration Indicator treatment outcome Referral Partial integration One-stop shop

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