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transport selectivity of a Diethylene Glycol Dimethacrylate- Based Thymine-imprinted Polymeric Membrane over a Cellulose Support for Nucleic Acid Bases

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Chinese Journal of Chemistry 2007年第2期25卷 213-218页

作者：曲祥金陈长宝周杰吴春辉 College of Chemistry and Material Science Shandong Agricultural University Tai'an Shandong 271018 China

The binding mechanism between 9-vinyladenine and pyrimidine base thymine in methanol was studied with UV-visible spectrophotometric method. Based on this study, using thymine as a template molecule, 9-vinyladenine as a novel functional monomer and diethylene glycol dimethacrylate as a new cross-linker, a specific diethylene glycol dimethacrylate-based molecularly imprinted polymeric membrane was prepared over a cellulose support. Then, the resultantly polymeric membrane morphologies were visualized with scanning electron microscopy and its permselectivity was examined using thymine, uracil, cytosine, adenine and guanine as substrates. This result showed that the imprinting polymeric membrane prepared with diethylene glycol dimethacrylate exhibited higher transport capacity for the template molecule thymine and its optimal analog uracil than other nucleic acid bases. The membrane also took on higher permselectivity than the imprinted membrane made with ethylene glycol dimethacrylate as a cross-linker. When a mixture including five nucleic acid bases thymine, uracil, cytosine, adenine and guanine passed through the diethylene glycol dimethacrylate-based thymine-imprinted polymeric membrane, recognition of the membrane for the template molecule thymine and its optimal analog uracil was demonstrated. It was predicted that the molecularly imprinted membrane prepared with diethylene glycol dimethacrylate as cross-linker might be applicable to thymine assay of absolute hydrolysates of DNA or uracil assay of absolute hydrolysates of RNA in biological samples because of its high selectivity for the template molecule thymine and its optimal analog uracil.

关键词： molecular imprinting transport selectivity thymine 9-vinyladenine diethylene glycol dimethacrylate

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Unimolecular artificial transmembrane channel with terminal dihydrogen phosphate groups showing transport selectivity for ammonium

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Chinese Chemical Letters 2020年第1期31卷 77-80页

作者： Jian-Yu Chen Qi Xiao Harekrushna Behera Jun-Li Hou Department of Chemistry Fudan University

A new artificial transmembrane channel molecule bearing dihydrogen phosphate groups has been *** terminal dihydrogen phosphate groups enable the channel to be highly negatively charged at both ends of the channel *** artificial channel could incorporate into the lipid bilayer efficiently under low *** channel displays high NH4+/K+selectivity due to the electrostatic interaction and hydrogen bonding between NH4+and the terminal dihydrogen phosphate groups.

关键词： Artificial transmembrane channel Ammonium transport Dihydrogen phosphate Pillararene Transmembrane transport transport selectivity

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Highly active artificial potassium channels having record-high K^(+)/Na^(+) selectivity of 20.1

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Chinese Chemical Letters 2023年第12期34卷 189-195页

作者： Haowen Ma Ruijuan Ye Lei Jin Shaoyuan Zhou Changliang Ren Haisheng Ren Jie Shen Huaqiang Zeng College of Chemistry Fuzhou UniversityFuzhou 350116China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi'an 710072China School of Pharmaceutical Sciences Xiamen UniversityXiamen 361102China Shenzhen Research Institute Xiamen UniversityShenzhen 518000China College of Chemical Engineering Sichuan UniversityChengdu 610065China

Replicating extraordinarily high membrane transport selectivity of protein channels in artificial channel is a challenging *** this work,we demonstrate that a strategic application of steric code-based social self-sorting offers a novel means to enhance ion transport selectivities of artificial ion channels,alongside with boosted ion transport *** specifically,two types of mutually compatible sterically bulky groups(benzo-crown ether and tert-butyl group)were appended onto a monopeptide-based scaffold,which can order the bulky groups onto the same side of a one-dimensionally aligned H-bonded *** steric repulsions among the same type of bulky groups(either benzo-crown ethers or tert-butyl groups),which are forced into proximity by H-bonds,favor the formation of hetero-oligomeric ensem-bles that carry an alternative arrangement of sterically compatible benzo-crown ethers and tert-butyl groups,rather than homo-oligomeric ensembles containing a single type of either benzo-crown ethers or tert-butyl *** with side chain tuning,this social self-sorting strategy delivers highly ac-tive hetero-oligomeric K+-selective ion channel(5F12-BF12)_(n),displaying the highest K+/Na+selectivity of 20.1 among artificial potassium channels and an excellent ECso value of 0.50μmol/L(0.62 mo1%relative to lipids)in terms of single channel concentration.

关键词： Supramolecular chemistry Artificial membrane transporters Artificial potassium channels Crown ethers Social self-sorting transport selectivity

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