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Experimental Study of the Antitumor Activity of Polymetalacrylates against Animal transplantable Tumors

Journal of Cancer Therapy 2010年第2期1卷 59-65页

作者： Larisa A. Ostrovskaya M. G. Voronkov D. B. Korman M. M. Fomina N. V. Bluhterova V. A. Rikova K. A. Abzaeva L. V. Zhilitskaya A.E. Favorsky Irkutsk Institute of Chemistry Siberian Branch of the Russian Academy of Sciences Irkutsk Russia N.M. Emanuel Institute of Biochemical Physics Russian Academy of Sciences Russian Moscow

The antitumor activity of the fourteen polymetalacrylates against two models of murine solid tumors (Lewis lung carcinoma and Acatol adenocarcinoma) as well as the acute toxicity of these compounds has been studied. It was shown that polyacrylates of noble metals (argent, aurum, platinum), namely argacryl (М = Ag), auracryl (М = Au) and platacryl (М = Pt) were the most effective agents among tested compounds against studied tumors. Thus, the tumor growth inhibitory effect of argacryl against Lewis lung carcinoma was equal to 90%, the life-span of treated by this compound animals has increased on 50% in comparison with control. Auracryl induced the inhibition of the Lewis lung carcinoma and Acatol adenocarcinoma development on 60 and 65%, correspondingly and the increasing of the mean life-span of animals with Lewis lung carcinoma on 20% in comparison with control. Platacryl inhibited the growth of Lewis lung carcinoma on 40% increasing the mean life-span of animals on 25% in comparison with control. In this way it was established that argacryl is the agent with the strongest antitumor activity among studied polymetalacrylates. On the basis of obtained data it seems possible to consider polymetalacrylates as a group of agents with the potential antitumor activity suitable for the further deep experimental investigation.

关键词： Polymetalcrylates Antitumor Activity transplantable Tumors of Animals

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Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells

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World Journal of Gastroenterology 2021年第29期27卷 4784-4801页

作者： Di Cao Jian-Yun Ge Yun Wang Tatsuya Oda Yun-Wen Zheng Institute of Regenerative Medicine and Affiliated Hospital of Jiangsu University Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine and School of Biotechnology and Heath SciencesWuyi UniversityJiangmen 529020Guangdong ProvinceChina School of Medicine Yokohama City UniversityYokohama 234-0006KanagawaJapan

Chronic infection with hepatitis B virus(HBV)remains a global health concern despite the availability of *** date,the development of effective treatments has been severely hampered by the lack of reliable,reproducible,and scalable in vitro modeling systems that precisely recapitulate the virus life cycle and represent virus-host *** the progressive understanding of liver organogenesis mechanisms,the development of human induced pluripotent stem cell(iPSC)-derived hepatic sources and stromal cellular compositions provides novel strategies for personalized modeling and treatment of liver ***,advancements in three-dimensional culture of self-organized liver-like organoids considerably promote in vitro modeling of intact human liver tissue,in terms of both hepatic function and other physiological *** with our experiences in the investigation of HBV infections using liver organoids,we have summarized the advances in modeling reported thus far and discussed the limitations and ongoing challenges in the application of liver organoids,particularly those with multi-cellular components derived from human *** review provides general guidelines for establishing clinical-grade iPSC-derived multi-cellular organoids in modeling personalized hepatitis virus infection and other liver diseases,as well as drug testing and transplantation therapy.

关键词： Hepatitis B virus Induced pluripotent stem cells Liver organoid Multicellular organoid Modeling transplantable

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