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Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial

引用

Chinese Medical Journal 2023年第5期136卷 541-549页

作者： Xiangyong Tian Bingqing Ji Xiaoge Niu Wenjing Duan Xiaoqiang Wu Guanghui Cao Chan Zhang Jingge Zhao Zhiwei Wang Yue Gu Huixia Cao Tao Qin Fengmin Shao Tianzhong Yan Department of Urology Henan Provincial People’s HospitalHenan Provincial Clinical Research Center for Kidney DiseaseZhengzhou University People’s HospitalHenan University People’Hospital ZhengzhouHenan 450003China Department of Nephrology Henan Provincial People’s HospitalHenan Provincial Key Laboratory of Kidney Disease and ImmunologyHenan Provincial Clinical Research Center for Kidney DiseaseZhengzhou University People’s HospitalHenan University People’Hospital ZhengzhouHenan 450003China Department of the Clinical Research Center Henan Provincial People’s HospitalZhengzhou University People’s HospitalHenan University People’Hospital ZhengzhouHenan 450003China Department of Hepatobiliary and Pancreatic Surgery Henan Provincial People’s HospitalZhengzhou University People’s HospitalHenan University People’Hospital ZhengzhouHenan 450003China.

Background:transplant renal artery stenosis(TRAS)is a vascular complication after kidney transplantation associated with poor *** study aimed to analyze the efficacy and safety of low-dose aspirin for preventing ***:After kidney transplantation,patients were enrolled from January 2018 to December 2020 in Henan Provincial People’s Hospital.A total of 351 enrolled recipients were randomized to an aspirin group with low-dose intake of aspirin in addition to standard treatment(n=178),or a control group with only standard treatment(n=173).The patients was initially diagnosed as TRAS(id-TRAS)by Doppler ultrasound,and confirmed cases were diagnosed by DSA(c-TRAS).Results:In the aspirin and control groups,15.7%(28/178)and 22.0%(38/173)of the recipients developed id-TRAS,respectively,with no statistical ***,for c-TRAS,the difference of incidence and cumulative incidence was statistically *** incidence of c-TRAS was lower in the aspirin group compared with the control group(2.8%[5/178]vs.11.6%[20/173],P=0.001).Kaplan–Meier estimates and Cox regression model identified the cumulative incidence and hazard ratio(HR)of TRAS over time in two groups,showing that recipients treated with aspirin had a significantly lower risk of c-TRAS than those who were not treated(log-rank P=0.001,HR=0.23,95%confidence interval[CI]:0.09–0.62).The levels of platelet aggregation rate(Prenal transplant could prevent the development of TRAS with no significant increase in adverse *** Registration:***,NCT04260828.

关键词： Kidney transplantation transplant renal artery stenosis Aspirin Prevention

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