检索结果-南通市图书馆

Polymorphisms of AZIN1 rs2679757 and TRPm5 rs886277 are Associated with Cirrhosis Risk in Chinese Patients with Chronic Hepatitis B

引用

国际感染病学（电子版） 2012年第2期1卷 103-109页

作者： Li-jun Peng Jin-sheng Guo Zhe Zhang Li-li Liu Yi-rong Cao Hong Shi Jian Wang Scott L.Friedman John J.Sninsky Ji-yao Wang Division of Digestive Diseases Department of Internal MedicineZhongshan HospitalShanghai Medical CollegeFudan University Division of Liver Diseases Mount Sinai School of Medicine Celera Corporation

Objective Genome-wide association studies(GWAS)have linked many single nucleotide polymorphisms(SNPs)to the outcomes of a variety of liver *** aim of the present study was to evaluate the association of several candidate SNPs with the risk and severity of cirrhosis due to chronic hepatitis B in a Chinese *** A total of 714 Chinese participants with persistent HBV infection were *** were divided into cirrhotic(n=429)and non-cirrhotic(n=285)groups based on clinical and pathological *** progression rate and severity of liver cirrhosis were evaluated with an arbitrary t-score *** of six SNPs in five candidate genes were detected with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(mALDI-TOF mS).The genotypic distributions of the SNPs were compared between the age-matched cirrhotic and non-cirrhotic *** association between the risk of SNPs and the severity and progression rate of cirrhosis was further *** Rs2679757 polymorphism of the antizyme inhibitor 1(AZIN1)gene and Rs886277 in the transient receptor potential cation channel subfamily m,member 5 gene(TRPm5)were found to be associated with cirrhosis risk in *** were also correlated with the overall severity and progression rate of *** frequencies of other SNPs were not different between the cirrhosis and non-cirrhosis *** AZIN1 rs2679757 and TRPm5 rs886277 are associated with the risk and the progression rate of HBV-related liver fibrosis in Chinese *** emerging SNPs associated with cirrhosis prognosis warrant further clinical validation in other CHB cohorts or ethnic groups,and merit mechanistic studies to reveal their roles in fibrosis progression.

关键词： Hepatitis B Cirrhosis Single nucleotide polymorphism Antizyme inhibitor 1 transient receptor potential cation channel subfamily m,member 5

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：