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Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial

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Chinese Medical Journal 2020年第1期133卷 61-67页

作者： Hong-Xing Wang Kun Wang Wen-Rui Zhang Wen-Feng Zhao Xiao-Tong Yang Li Wang Mao Peng Zhi-Chao Sun Qing Xue Yu Jia Ning Li Kai Dong Qian Zhang Shu-Qin Zhan Bao-Quan Min Chun-Qiu Fan Ai-Hong Zhou Hai-Qing Song Lu Yin Tian-Mei Si Jing Huang Jie Lu Hai-Xia Leng Wei-Jun Ding Yuan Liu Tian-Yi Yan Yu-Ping Wang Departm ent of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Neuromodulation Beijing 100053China Center of Epilepsy Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurology Beijing Puren HospitalBeijing 100062China Medical Research&Biometrics Centre National Centre for Cardiovascular DiseasesBeijing 102300China Peking University Sixth Hospital Beijing 100083China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China School of Life Science Beijing Institute of TechnologyBeijing 100081China

Background:transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating ***:This is an 8-week,double-blind,randomized,placebo-controlled ***-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min,77.5-Hz,15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week *** outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52,with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week *** will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire ***:The tACS applied in this trial may have treatment effects on MDD with minimal side *** registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://***/***?proj=22048.

关键词： Major depressive disorder transcranial alternating current stimulation Treatment Trial

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Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation

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Brain Science Advances 2023年第2期9卷 114-135页

作者： Tiantian Liu Zilong Yan Ziteng Han Jian Zhang Boyan Fang Tianyi Yan School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China Parkinson Medical Center Beijing Rehabilitation HospitalCapital Medical UniversityBeijing 100144China

Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 20 patients with PD and 20 normal controls(NC).Each patient with PD received successivemultidisciplinary intensive rehabilitation treatment and tACStreatment over a one-year *** functional brain network mapping and co-activation pattern(CAP)analysis were performed to characterize cortico–subcortical ***:The same tACS electrode placement stimulated different proportions of functional brain networks across the *** analysis revealed that the visual network,attentional network,and default mode network co-activated with the thalamus,accumbens,and amygdala,*** pattern characterized by thede-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than inNCs,and this amplitude increased after tACS ***,the co-occurrence of cortico–subcortical CAPs was significantly higherin patients with PD than in NCs and decreased after tACS ***:This study investigated cortico–subcortical spatiotemporaldynamics in patients with PD and further revealed the tACS *** findings contribute to understanding cortico–subcortical dynamics and exploring noninvasive neuromodulationtargets of cortico–subcortical circuits in brain diseases,such as PD,Alzheimer’s disease,and depression.

关键词： spatiotemporal dynamics cortico–subcortical co-activation pattern transcranial alternating current stimulation Parkinson’s disease resting-state functional MRI

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