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Current status of yttrium-90 microspheres radioembolization in primary and metastatic liver cancer

Journal of Interventional Medicine 2023年第4期6卷 152-158页

作者： Yasaman Anbari Floortje E.Veerman Grace Keane Arthur J.A.T.Braat Maarten L.J.Smits Rutger C.G.Bruijnen Wenle Tan Ye Li Feng Duan Marnix G.E.H.Lam University Medical Center Utrecht Utrechtthe Netherlands Interventional Radiology Department Chinese PLA General HospitalBeijingChina

Liver malignancy,including primary liver cancer and metastatic liver cancer has become one of the most common causes of cancer-related death worldwide due to the high malignant degree and limited systematic treatment *** with yttrium-90(^(90)Y)-loaded microspheres is a relatively novel technology that has made significant progress in the local treatment of liver *** different steps in the extensive work-up of radioembolization for patients with an indication for treatment with^(90)Y microspheres,from patient selection to follow up,both technically and clinically,are discussed in this *** describes the application and development of^(90)Y microspheres in the treatment of liver cancer.

关键词： Yttrium-90 microspheres Primary liver cancer Metastatic liver cancer Selective internal radiation therapy trans-arterial radioembolization

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Hepatocellular Carcinoma and the Role of Liver transplantation:A Review

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Journal of Clinical and translational Hepatology 2021年第5期9卷 738-748页

作者： Haris Muhammad Aniqa Tehreem Peng-Sheng Ting Merve Gurakar Sean Young Li Cem Simsek Saleh A.Alqahtani Amy K.Kim Ruhail Kohli Ahmet Gurakar Department of Internal Medicine Greater Baltimore Medical CenterMDUSA Department of Internal Medicine Sinai HospitalBaltimoreMDUSA Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Medicine Osler Residency ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Duke University DurhamNCUSA

Hepatocellular carcinoma(HCC)is one of the leading causes of cancer deaths worldwide and liver transplantation(LT)is the only potentially curative *** the years,Milan criteria has been used for patient *** is ongoing research in this field with introduction of new biomarkers for HCC that can help guide future ***,newer therapies for downstaging of the tumor are being implemented to prevent dropout from the transplant *** addition,combination therapies for better outcome are under ***,the concept of living-donor LT and possible use of hepatitis C virus-positive donors has been implemented as an attempt to expand the organ ***,there is a conflict of opinion between different centers regarding its efficacy and data is *** aim of this review article is to outline the various selection criteria for LT,discuss the outcomes of LT in HCC patients,and explore future directions of LT for ***,a comprehensive PubMed/MEDLINE review was *** expand our search,references of the retrieved articles were also screened for additional *** selecting the studies,the authors independently reviewed them to identify the relevant *** careful evaluation 120 studies relevant to out topic are cited in the *** tables and two figures are also *** conclusion LT for HCC has evolved over the *** the introduction of several expanded criteria beyond Milan,the introduction of bridging therapies,such as transcatheter arterial chemoembolization and radiofrequency ablation,and the approval of newer systemic therapies,it is evident that there will be more LT recipients in the *** is promising to see ongoing trials and the continuous evolution of *** studies are needed to guide the development of a pre-LT criteria that can ensure low HCC recurrence risk and is not overly stringent,clarify the role of LDLT,and determine the optimal bridgin

关键词： Hepatocellular carcinoma Liver transplantation Model for endstage liver disease trans-arterial radioembolization Locoregional therapies

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