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Serum metabolic profiling of traditional chinese medicine syndromes in patients with diarrhea-predominant irritable bowel syndrome

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Journal of Integrative medicine 2021年第3期19卷 274-281页

作者： Si-qi Tang Yun-liang Wang Zi-ye Xie Yang Zhang Yi Guo Kang-li Gao Tang-you Mao Chun-e Xie Jun-xiang Li Xiao-yan Gao School of chinese Material Medica Beijing University of Chinese MedicineBeijing 102488China Gastroenterology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Gastroenterology Department Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Gastroenterology Department First Affiliated HospitalAnhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

Objective:The clinical symptoms of diarrhea-predominant irritable bowel syndrome(IBS-D)can be effectively improved by traditional chinese medicine(TCM)treatment,based on the usage of specific therapies for different TCM syndromes.However,in the stage of diagnosis,the standard criteria for the classification of TCM syndrome were still deficient.Through serum metabolic profiling,this study aimed to explore potential biomarkers in IBS-D patients with different TCM syndromes,which can assist in diagnosis of the disease.Methods:Serum samples were collected from healthy controls(30 cases),IBS-D patients with LiverStagnation and Spleen-Deficiency syndrome(LSSD,30 cases),Yang Deficiency of Spleen and Kidney syndrome(YDSK,11 cases)and Damp Abundance due to Spleen-Deficiency syndrome(DASD,22 cases).Serum metabolic profiling was conducted by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.The potential biomarkers were screened by orthogonal partial least square-discriminate analysis,while metabolic pathways undergoing alterations were identified by pathway enrichment analysis in Metabo Analyst 4.0.Results:Overall,34 potential biomarkers were identified in LSSD group,36 in YDSK group and 31 in DASD group.And the 13 metabolites shared by three groups were determined as the potential biomarkers of IBS-D.Glycerophospholipid metabolism was disturbed significantly in IBS-D patients,which may play a role in IBS-D through inflammation.What’s more,three TCM syndromes have the specific potential biomarkers in glycerophospholipid metabolism.Conclusion:The serum metabolomics revealed that different TCM syndrome types in IBS-D may have different metabolic patterns during disease progression and glycerophospholipid metabolism was one of the pathways,whose metabolism was disturbed differently among three TCM syndromes in IBS-D.Therefore,the specific potential biomarkers in glycerophospholipid metabolism of three TCM syndromes in IBS-D can serve as the objective indicators,which can facilita

关键词： Diarrhe Irritable bowel syndrome Metabolomics traditional chinese medicine syndromes

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Prognostic significance of identification of traditional chinese medicine syndromes in colorectal cancer

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traditional medicine Research 2023年第10期8卷 1-10页

作者： Guo-Hang Huang Yu-Qi Liang Qing-Hua Xie Yuan-Hao Hu Zheng-Lin Liu Qi-Sheng Zhong Jun-Wei Chen Yan-Hai Lyu Quan-Feng Zhang Dang-Fang Gu Yong-Qiang Wu Jun-Yu Ke The Rehabilitation medicine Department The Third Affiliated Hospital of Sun Yan-Sen UniversityGuangzhou 510630China The Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510006China Animal Experiment Center Guangzhou University of Chinese MedicineGuangzhou 510006China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006China The First Clinical Medical College Guangzhou University of Traditional Chinese MedicineGuangzhou 510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou 525200China The Basic Medical College Guangzhou University of Chinese MedicineGuangzhou 510006China

Background:traditional chinese medicine(TCM)syndrome is the basic unit of TCM treatment,which help clinicians assess the disease progression and treatment preoperative of tumor patients.However,the prognostic significance of TCM syndrome is still unclear.This study aims to detect the differences in overall survival between different TCM syndrome and further develop a new nomogram with TCM syndrome for predicting overall survival in colorectal cancer.Methods:A total of 324 patients with colorectal cancer were enrolled and categorized into three groups based on TCM syndrome:deficiency,excess,and deficiency-excess.The prognosis of colorectal cancer patients with different TCM syndromes was evaluated using Kaplan-Meier analysis and Cox regression analysis.Results:The proportion of advanced stage and lymph metastasis in the patients with deficiency syndrome was higher,and the overall survival was shorter than other syndromes.Meanwhile,the TCM syndrome(Psyndromes and tumor information is helpful for risk stratification and prognostic predictions in colorectal cancer preoperatively.

关键词： colorectal cancer traditional chinese medicine syndromes overall survival prognosis nomogram

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Tongue diagnosis based on hue-saturation value color space: controlled study of tongue appearance in patients treated with percutaneous coronary intervention for coronary heart disease

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Intelligent medicine 2023年第4期3卷 252-257页

作者： Yumo Xia Qingsheng Wang Xiao Feng Xin’ang Xiao Yiqin Wang Zhaoxia Xu Basic Medical College Shanghai University of Traditional Chinese MedicineShanghai 201203China

Objective To analyze the characteristics of tongue imaging color parameters in patients treated with percutaneous coronary intervention(PCI)and non-PCI for coronary atherosclerotic heart disease(CHD),and to observethe effects of PCI on the tongue images of patients as a basis for the clinical diagnosis and treatment of patientswith CHD.Methods This study used a retrospective cross-sectional survey to analyze tongue photographs and medicalhistory information from 204 patients with CHD between November 2018 and July 2020.Tongue images ofeach subject were obtained using the Z-BOX Series traditional chinese medicine(TCM)intelligent diagnosisinstruments,the SMX System 2.0 was used to transform the image data into parameters in the HSV color space,and finally the parameters of the tongue image between patients in the PCI-treated and non-PCI-treated groupsfor CHD were analyzed.Results Among the 204 patients,112 were in the non-PCI treatment group(38 men and 74 women;average age of(68.76±9.49)years),92 were in the PCI treatment group(66 men and 26 women;average age of(66.02±10.22)years).In the PCI treatment group,the H values of the middle and tip of the tongue and the overall coating of thetongue were lower(P<0.05),while the V values of the middle,tip,both sides of the tongue,the whole tongueand the overall coating of the tongue were higher(P<0.05).Conclusion The color parameters of the tongue image could reflect the physical state of patients treated withPCI,which may provide a basis for the clinical diagnosis and treatment of patients with CHD.

关键词： Objective evaluation Tongue diagnosis Coronary heart disease Percutaneous coronary intervention Hue-saturation value color space traditional chinese medicine syndromes

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Clinical efficacy and safety of Guipi decoction combined with escitalopram oxalate tablets in patients with depression

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World Journal of Clinical Cases 2023年第29期11卷 7017-7025页

作者： Jia Yu Feng-Quan Xu Psychiatry Department Beijing Changping Hospital of Traditional and Western MedicineBeijing 102206China Department of Psychosomatic medicine Guang'anmen HospitalChinese Academy of Traditional Chinese MedicineBeijing 100053China

BACKGROUND Depression is a widespread mental health condition that requires effective treatment.In the treatment of depression,traditional chinese medicine(TCM)offers obvious advantages,fewer adverse reactions,and a lower recurrence rate.AIM To evaluate the clinical benefits of Guipi decoction combined with escitalopram oxalate tablets for individuals with depression.METHODS In total,80 patients diagnosed as having depression were enrolled in the study and divided into either an experimental group or a control group.All of the patients were orally administered escitalopram oxalate tablets.Additionally,the experimental group received Jiajian Guipi decoction and reduced Governor vessel fumigation over 4 wk.TCM syndrome scores,Hamilton depression rating scale(HAM-D)scores,self-rating depression scale(SDS)scores,and Pittsburgh sleep quality index scores were measured for the two groups and compared before and after the treatment.The two groups were monitored for any adverse reactions.RESULTS After 4 wk of treatment,both groups exhibited a significant reduction in TCM syndrome scores compared with their pre-treatment scores(P<0.05).However,the experimental group exhibited significantly lower TCM syndrome scores than the control group(P<0.05).Similarly,the post-treatment SDS and HAM-D-24 scores were significantly lower in both groups than the pre-treatment scores(P<0.05),with the experimental group exhibiting lower scores than the control group(P<0.05).The total treatment efficiency was significantly better in the experimental group(97.14%)than in the control group(77.78%)(P<0.05).Furthermore,after 4 wk of treatment,the Pittsburgh sleep quality index scores for both groups were significantly lower than those before the treatment(P<0.05),with the experimental group exhibiting lower scores than the control group(P<0.05).The incidence of adverse reactions was significantly lower in the experimental group than in the control group(P<0.05).CONCLUSION The combination of Guipi decoction and escitalopram oxalate tablets was fo

关键词： Jiajian Guipi decoction Escitalopram oxalate tablets Depressive disorder Sleep quality traditional chinese medicine syndromes

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Characteristics of traditional chinese medicine Syndrome in Patients with Coronary Heart Disease at Different Disease Stages

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World Journal of traditional chinese medicine 2022年第2期8卷 218-224页

作者： Yu-Mo Xia Hui Gao Qing-Sheng Wang Xiao Feng Yi-Qin Wang Zhao-Xia Xu Shanghai Key Laboratory of Health Identification and Assessment Basic Medical CollegeShanghai University of Traditional Chinese MedicineShanghaiChina

Coronary atherosclerotic heart disease(CHD)has a high incidence,disability rate,and mortality rate,which severely affect people’s health,work,and life.Based on its clinical manifestations,traditional chinese medicine(TCM)has classified CHD as“chest impediment”and“heart pain”for the treatment.The course of CHD is protracted,and the pathogenesis is complex and changeable.Moreover,different disease stages have different syndrome characteristics.Thus,this article aimed to summarize the classification and distribution characteristics of the TCM syndrome in various stages of CHD,such as before and after percutaneous coronary intervention therapy,disease progression,age,and complications,to provide references for the TCM clinical diagnosis and treatment of CHD.

关键词： Coronary heart disease different disease stages review traditional chinese medicine syndromes

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Immediate effects of scalp acupuncture with twirling reinforcing manipulation on hemiplegia following acute ischemic stroke: a hidden association study

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Neural Regeneration Research 2016年第5期11卷 758-764页

作者： Xiao-zheng Du Chun-ling Bao Gui-rong Dong Xu-ming Yang School of Acupuncture and Manipulation Gansu University of Chinese Medicine Department of Acupuncture Yueyang Hospital of Integrated Medicine Shanghai University of Traditional Chinese Medicine School of Acupuncture and Manipulation Shanghai University of Traditional Chinese Medicine

Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper a

关键词： nerve regeneration traditional chinese medicine needling reinforcing manipulation hemiplegia due to acute ischemic stroke im- mediate effect association algorithm artificial neural network algorithm neurological deficit score simplified Fugl-Meyer assessment Hmax/Mmax traditional chinese medicine syndromes scalp acupoints neural regeneration

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Exploring medication rules in chinese randomized controlled trials of type 2 diabetes based on data mining technology

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Medical Data Mining 2023年第4期6卷 46-57页

作者： Zhi-Li Dou Hao-Nan Sun Yu-Nan Zhang Lei Zhao Zhe Huang Shu-Jing Xu Yi-Xing Liu Dong-Ran Han Jin-Zhu Jia Department of Biostatistics School of Public HealthPeking UniversityBeijing 100191China The School of Life Science Beijing University of Chinese MedicineBeijing 102446China The School of Management Beijing University of Chinese MedicineBeijing 102446China Center for Statistical Sciences Peking UniversityBeijing 100781China

Background:To systematically summarize and categorize the chinese herbal medicine in the domestic traditional chinese medicine(TCM)literature on type 2 diabetes mellitus(T2DM),in this paper,we mine traditional chinese medicine data for relationships and provide for future practitioners and researchers.Methods:Taking randomized controlled trials on the treatment of T2DM in TCM as the research theme,we searched for full-text literature in three major clinical databases,including CNKI,Wan Fang,and VIP,published between 1990 and 2020.We then conducted frequency statistics,cluster analysis,association rules extraction,and principal component analysis based on a corpus of medical academic words extracted from 1116 research articles.Results:The most frequently used is Astragali Radix,and the most commonly used two-herb combination in T2DM treatment consisted of Coptidis Rhizoma and Moutan Cortex.Moutan Cortex,Alismatis Rhizoma,and Dioscoreae Rhizoma were the most frequently used three-herb combination.We found a“lung”and“liver”and“kidney”model and confirmed the value of classical meridian tropism theory and pattern identification.The treatment is mainly to fill deficiency and clear heat and consider water infiltration,dampness,blood circulation,and silt.Conclusion:This study provides an in-depth perspective on the TCM medication rules for T2DM and offers practitioners and researchers valuable information about the current status and frontier trends of TCM research on T2DM in terms of diagnosis and treatment.

关键词： type 2 diabetes mellitus traditional chinese medicine syndromes chinese herbal medicine data mining

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