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Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study

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Neural Regeneration Research 2019年第9期14卷 1556-1561页

作者： Sung Ho Jang Seong Ho Kim Han Do Lee Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea Department of Neurosurgery College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea

The cingulum,connecting the orbitofrontal cortex to the medial temporal lobe,involves in diverse cognition functions including attention,memory,and motivation.To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury,we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury(39 males,34 females,age 43.29±11.42 years)and 40 healthy controls(22 males,18 females,age 40.11±16.81 years).The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography:subgroup A(n=19 patients)– both sides of the anterior cingulum were intact;subgroup B(n=36 patients)– either side of the anterior cingulum was intact;and subgroup C(18 patients)– both sides of the anterior cingulum were discontinued.There were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and C.There were no significant differences in diffusion tensor tractography parameters(fractional anisotropy,apparent diffusion coefficient,and fiber volume)between patients and controls.These findings suggest that the integrity between the anterior cingulum and the basal forebrain,but not diffusion tensor tractography parameter,can be used to predict the cognitive function of patients with chronic mild traumatic brain injury.This study was approved by Yeungnam University Hospital Institutional Review Board(approval No.YUMC-2014-01-425-010)on August 16,2017.

关键词： mild traumatic brain injury brain trauma diffusion tensor tractography diffusion tensor imaging cognitive impairment cingulum memory Glasgow Coma Scale neural regeneration

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Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease

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Neuroprotection 2023年第1期1卷 66-83页

作者： Ashwinee Manivannan Lesley M.Foley T.Kevin Hitchens Ivan Rattray Gillian P.Bates Michel Modo Department of Neuroscience University of PittsburghPittsburghPennsylvaniaUSA Animal Imaging Center University of PittsburghPittsburghPennsylvaniaUSA Department of Neurobiology University of PittsburghPittsburghPennsylvaniaUSA Department of Neurodegenerative Disease Queen Square Institute of NeurologyHuntington's Disease Centre and UK Dementia Research Institute at UCLUniversity College LondonLondonUK Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Center for the Neural Basis of Cognition University of PittsburghPittsburghPennsylvaniaUSA

Background:Huntington's disease is a progressive neurodegenerative disorder.Brain atrophy,as measured by volumetric magnetic resonance imaging(MRI),is a downstream consequence of neurodegeneration,but microstructural changes within brain tissue are expected to precede this volumetric decline.The tissue microstructure can be assayed non-invasively using diffusion MRI,which also allows a tractographic analysis of brain connectivity.Methods:We here used ex vivo diffusion MRI(11.7 T)to measure microstructural changes in different brain regions of end-stage(14 weeks of age)wild type and R6/2 mice(male and female)modeling Huntington's disease.To probe the microstructure of different brain regions,reduce partial volume effects and measure connectivity between different regions,a 100μm isotropic voxel resolution was acquired.Results:Although fractional anisotropy did not reveal any difference between wild-type controls and R6/2 mice,mean,axial,and radial diffusivity were increased in female R6/2 mice and decreased in male R6/2 mice.Whole brain streamlines were only reduced in male R6/2 mice,but streamline density was increased.Region-to-region tractography indicated reductions in connectivity between the cortex,hippocampus,and thalamus with the striatum,as well as within the basal ganglia(striatum—globus pallidus—subthalamic nucleus—substantia nigra—thalamus).Conclusions:Biological sex and left/right hemisphere affected tractographic results,potentially reflecting different stages of disease progression.This proof-of-principle study indicates that diffusion MRI and tractography potentially provide novel biomarkers that connect volumetric changes across different brain regions.In a translation setting,these measurements constitute a novel tool to assess the therapeutic impact of interventions such as neuroprotective agents in transgenic models,as well as patients with Huntington's disease.

关键词： connectome diffusion tensor imaging Huntington's disease mouse MRI tractography

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Improvement of ataxia in a patient with cerebellar infarction by recovery of injured cortico-ponto-cerebellar tract and dentato-rubro-thalamic tract: a diffusion tensor tractography study

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Neural Regeneration Research 2019年第8期14卷 1470-1472页

作者： Sung Ho Jang Hyeok Gyu Kwon Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health Science Eulji University Gyeonggi Republic of Korea

Coordinated movement is generated by communication between the cerebrum and cerebellum via the cerebellar peduncles (CPs). The CPs are classified into three types (superior, middle, and inferior), and each includes a variety of neural tracts. Among those tracts, the cortico-ponto-cerebellar tract (CPCT), a middle CP, is involved in motor planning and initiation of movement, while the dentato-rubro-thalamic tract (DRTT), a superior CP, is involved in motor coordination, movement timing, verbal fluency, and working memory (Kase et al., 1993.

关键词： Improvement of ataxia injured cortico-ponto-cerebellar tractography study

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Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1304-1310页

作者： Chun-Nan Wu Shao-Feng Duan Xue-Tao Mu Yi Wang Peng-Yu Lan Xiao-Lu Wang Kun-Cheng Li Department of Radiology Xuanwu HospitalCapitalMedical UniversityBeijing100053China Department of Radiology the Third Medical Center ofChinese PLA General HospitalBeijing100039China Division of Nuclear Technology and Applications Institute ofHigh Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Engineering Research Center of RadiographicTechniques and Equipment Beijing100049China Orbital Disease Institute the Third Medical Center of ChinesePLA General HospitalBeijing100039China Department of Otolaryngology the Third Medical Center ofChinese PLA General HospitalBeijing100039China

AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tractography(PDT). METHODS: Twenty patients with orbital space-occupying lesions and 25 age-and gender-matched healthy persons were included. All patients and controls underwent routine orbital magnetic resonance imaging and diffusion tensor imaging(DTI), using a 3.0 T magnetic resonance scanner(Trio Tim Siemens). After the image data were preprocessed, each DTI parameters of the optic nerve and optic tract was obtained by PDT, including fractional anisotropy(FA), mean diffusivity(MD), axial diffusivity(AD) and radial diffusivity(RD). The asymmetry index(AI) of each parameter was calculated. Compared the parameters of the affected side optic nerve and ipsilateral optic tract with the contralateral side by paired sample t-test;compared AI of parameters of optic nerve and optic tract between the patient group and the control group by independent sample t-test. Patients were divided into threesubgroups according to the low vision grade standard of WHO, compared the FA and AI of FA between the three subgroups by single factor variance analysis. RESULTS: The affected side optic nerve presented significantly decreased FA, increased MD, AD, and RD values compared to the unaffected side(P0.05). The AIs of the FA value of the optic nerve in the eyesight <0.1 subgroup was significantly higher than that in the other groups(P<0.05). CONCLUSION: FA, MD, AD, and RD of the affected side optic nerve of the orbital space-occupying lesions have significantly changed, the FA value is the most sensitive. The PDT

关键词： orbital space-occupying lesions decreased vision optic never and optic tract probabilistic diffusion tractography magnetic resonance imaging

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Correlation between muscular strength and basal nuclei ischemic/hemorrhagic stroke-induced corticospinal tract injury,as detected by diffusion tensor imaging and tractography

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Neural Regeneration Research 2010年第13期5卷 1010-1014页

作者： Shangwen Xu Ziqian Chen Jinhua Chen Youqiang Ye Yuning Lin Ping Ni Hui Xiao Gennian Qian Department of Medical Imaging Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA Fuzhou 350025 Fujian Province China Statistical Division of Department of Medical Affairs Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA Fuzhou 350025 Fujian Province China Department of Medical Bioengineering Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA Fuzhou 350025 Fujian Province China

BACKGROUND： Conventional neuroimaging diagnosis does not assist with the monitoring or evaluation of basal nuclei ischemic and hemorrhagic stroke, or motor functional recovery. Magnetic resonance, diffusion tensor imaging, and diffusion tensor tractography have all been used to observe features of cerebral white matter fibrous structures. In addition, diffusion tensor tractography is the only non-invasive imaging method to display the corticospinal tract in vivo. OBJECTIVE： To evaluate the impairment degree of corticospinal tract induced by basal nuclei ischemic and hemorrhagic stroke through the use of magnetic resonance, diffusion tensor imaging, and diffusion tensor tractography, and to analyze the correlation to muscular strength. DESIGN, TIME AND SETTING： A retrospective case analysis was performed at the Department of Medical Imaging, Neurology and Neurosurgery, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA between November 2002 and June 2008. PARTICIPANTS： A total of 15 patients with acute or subacute cerebral ischemic stroke and nine with hemorrhagic stroke in the basal nuclei were selected. METHODS： Magnetic resonance, diffusion tensor imaging, and diffusion tensor tractography results and data were analyzed. Fractional anisotropy and directionally encoded color maps were obtained. Three-dimensional tractography of bilateral corticospinal tract was created, and corticospinal tract integrity was graded. Fractional anisotropy of infarct region and corresponding contralateral normal regions were measured, and hematoma volume in hemorrhagic stroke patients was determined. Hand motor function ability was evaluated using Brunstorm criteria. MAIN OUTCOME MEASURES： Fractional anisotropy of infarct region and corresponding contralateral normal regions; hematoma volume in hemorrhagic stroke patients; correlation between muscular strength and corticospinal tract impairment degree in ischemic stroke and hemorrhagic stroke patients before and after treatment. RESULTS： In ischemic stroke pati

关键词： ischemic stroke hemorrhagic stroke magnetic resonance diffusion tensor imaging tractography brain injury neural regeneration

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Quantitative study of prostate cancer using three dimensional fiber tractography

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World Journal of Radiology 2016年第4期8卷 397-402页

作者： Sandeep Hedgire Alexey Tonyushkin Aoife Kilcoyne Jason A Efstathiou Peter F Hahn Mukesh Harisinghani Department of Radiology Massachusetts General Hospital Department of Physics UMass

AIM:To investigate feasibility of a quantitative study of prostate cancer using three dimensional(3D)fiber tractography.METHODS:In this institutional review board approved retrospective study,24 men with biopsy proven prostate cancer underwent prostate magnetic resonance imaging(MRI)with an endorectal coil on a 1.5 T MRI scanner.Single shot echo-planar diffusion weighted images were acquired with b = 0.600 s/mm^2,six gradient directions.Open-source available software Track Vis and its Diffusion Toolkit were used to generate diffusion tensor imaging(DTI)map and 3D fiber tracts.Multiple 3D spherical regions of interest were drawn over the areas of tumor and healthy prostatic parenchyma to measure tract density,apparent diffusion coefficient(ADC)and fractional anisotropy(FA),which were statistically analyzed.RESULTS:DTI tractography showed rich fiber tract anatomy with tract heterogeneity.Mean tumor region and normal parenchymal tract densities were 2.53 and 3.37 respectively(P tractography of the prostate is feasible and depicts congregate fibers within the gland.Tract density may offer new biomarker to distinguish tumor from normal tissue.

关键词： Prostate cancer Tract density Diffusion tensor imaging tractography Magnetic resonance imaging

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Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects

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World Journal of Clinical Cases 2022年第24期10卷 8450-8462页

作者： Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia Department of Radiology School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia School of Computer Sciences Universiti Sains Malaysia11800 USMPenangMalaysia Department of Neurosciences Hospital Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia

Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain elusive.Enhanced relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in CSVD.Diffusion tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter damage.However,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical use.In this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关键词： Diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing tractography

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Diffusion tensor tractography of the arcuate fasciculus in patients with brain tumors: Comparison between deterministic and probabilistic models

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Journal of Biomedical Science and Engineering 2013年第2期6卷 192-200页

作者： Zhixi Li Kyung K. Peck Nicole P. Brennan Mehrnaz Jenabi Meier Hsu Zhigang Zhang Andrei I. Holodny Robert J. Young Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer Center New York USA Department of Radiology Memorial Sloan-Kettering Cancer Center New York USA

Purpose: The purpose of this study was to compare the deterministic and probabilistic tracking methods of diffusion tensor white matter fiber tractography in patients with brain tumors. Materials and Methods: We identified 29 patients with left brain tumors ciculus was reconstructed using a deterministic Fiber Assignment by Continuous Tracking (FACT) algorithm and a probabilistic method based on an extended Monte Carlo Random Walk algorithm. Tracking was controlled using two ROIs corresponding to Broca’s and Wernicke’s areas. Tracts in tumoraffected hemispheres were examined for extension between Broca’s and Wernicke’s areas, anterior-posterior length and volume, and compared with the normal contralateral tracts. Results: Probabilistic tracts displayed more complete anterior extension to Broca’s area than did FACT tracts on the tumor-affected and normal sides (p rs.

关键词： Diffusion Tensor Imaging DTI tractography Probabilistic FACT Arcuate Fasciculus Brain Tumors

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Probabilistic tractography of the posterior subthalamic area in Parkinson’s disease patients

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Journal of Biomedical Science and Engineering 2013年第3期6卷 381-390页

作者： M.G.GarcIa-Gomar Luis Concha S.Alcauter J.Soto Abraham J.D.Carrillo-Ruiz G.Castro Farfan Francisco Velasco Campos Neurobiology Institute UNAM Campus JuriquillaJuriquillaQueretaroMexico National Institute of Psychiatry“Ramón de la Fuente Muniz” México CityMéxico Unit for Stereotactic and Functional Neurosurgery and Radiosurgery México General HospitalMéxico CityMéxico

Deep brain stimulation (DBS) is a non-pharmacological treatment for Parkinson’s disease (PD), and its efficacy depends largely on which anatomical structure (target) is stimulated. The subthalamic nucleus (STN) is one of the most commonly used targets, but stimulation of new targets within the posterior sub-thalamic area (PSA), comprising a group of white matter fibers known as prelemniscal radiations (Raprl), as well as the caudal zonaincerta nucleus (Zic), have proven to be superior at improving certain clinical symptoms. Despite their clinical usefulness, their anatomical connectivity has not been completely described in humans. We performed constrained spherical deconvolution of the signal in diffusion-weighted images and subsequent tractography as a means to non-invasively define the connectivity of the Raprl and Zic in a group of five patients with PD. Further, we used track-density imaging, a novel method to improve the spatial resolution of the acquired images, in order to visualize the small subregions that comprise the PSA with a voxel resolution of 0.2 × 0.2 × 0.2 mm3. Both Raprl and Zic demonstrated high probability of connectivity with the dorsal brainstem, cerebellum, subcortical nuclei (globus pallidum ventral, lateral thalamic nuclei), and cortical areas (orbitofrontal cortex, primary and supplementary motor cortex areas). The connectivity patterns were re-producible between patients and were discretely organized as the tracts entered/exited the PSA, depending on their end points. These findings indicate that the PSA is part of the neuronal circuitry controlling movement, and the precise characterization of its connectivity will aid in our understanding of the net-works involved in PD and how they can be modulated with DBS in order to alleviate symptoms.

关键词： Parkinson Disease(PD) Posterior Subthalamic Area(PSA) tractography Track-Density Images(TDI)

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Cost Analysis of Diffusion Tensor Imaging and MR tractography of the Brain

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Open Journal of Radiology 2014年第3期4卷 260-269页

作者： Christopher Hancock Byron Bernal Camila Medina Santiago Medina Miami Children’s Hospital Miami USA

Purpose: To determine the total direct costs (fixed and variable costs) of diffusion tensor imaging (DTI) and MR tractography reconstruction of the brain. Materials and Methods: The direct fixed and variable costs of DTI with MR tractography were determined prospectively with time and motion analysis in a 1.5-Tesla MR scanner using 15 encoding directions. Seventeen patients with seizure disorders, 9 males & 8 females, with mean age of 13 years (age range 2 - 33 years) were studied. Total direct costs were calculated from all direct fixed and variable costs. Sensitivity analyses between 1.5 versus a 3-Tesla MR system, and 15 versus 32 encoding directions were done. Results: The total direct costs of DTI and MR tractography for a 1.5-T system with 15 encoding directions were US $97. Variable cost was $76.80 and fixed cost was $20.20. Total direct costs for a 3-T system with 15 directions decreased to US $94.5 because of the shorter scan time despite the higher cost of the 3-T system. The most costly component of the direct cost was post-processing analysis at US $46.00. Conclusion: DTI with MR tractography has important total direct costs with variable costs higher than the fixed costs. The post processing variable cost is the most expensive component. Developing more accurate automated post-processing software for DTI and MR tractography is important to decrease this variable labor cost. Given the added value of DTI-MR tractography and the costs involved reimbursement codes should be considered.

关键词： tractography Diffusion Tensor Imaging MRI Pediatrics Brain Cost Analysis Functional

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