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tpeak-tend interval as a new risk factor for arrhythmic event in pa-tient with Brugada syndrome

Journal of Nanjing Medical University 2007年第4期21卷 213-217页

作者： Jinfeng Wang Qijun Shan Bing Yang Minglong Chen Jiangang Zou Dongjie Xu Chun Chen Kejiang Cao Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

Objective：To evaluate tpeak-tend （Tp-e） interval in surface standard ECG as a new risk factor for arrhythmic event in patient with Brugada syndrome. Methods： 23 male patients with Brugada syndrome and 20 male patients with paroxysmal supraventricular tachycardia （PSVT） as the control group were investigated in this study. Tp-e interval in surface standard ECG was compared between BrS and PSVT patients. Results： Tp-e interval in BrS patients was significantly longer than that in PSVT patients （109.57±22.86 ms vs. 88.50±13.08ms, P〈0.05）. There was significant difference in Tp-e interval between 16 BrS patients with arrhythmic events （including syncope, clinical ventricular fibrillation [VF] and programmed electrica/ stimulation [PES]-induced VF） and 7 BrS patients without arrhythmic events and PSVT patients （118.12±20.40ms vs. 90.00±15.27ms, P〈0.05; 118.12±20.40ms vs. 88.50±13.08ms, P〈0.05）. However, Tp-e interval was similar in BrS patients without arrhythmic events and PSVT patients （90.00±15.27ms vs 88.50±13.08ms, P〉0.05）. Conclusion： The prolongation of Tp-e interval could serve as a new noninvasive event predictor for arrhythmic events in patients with Brugada syndrome.

关键词： Brugada syndrome tpeak-tend risk factors

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Electrocardiographic measures of repolarization dispersion and their relationships with echocardiographic indices of ventricular remodeling and premature ventricular beats in hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 717-724页

作者： Ana Ciobanu Gary Tse Tong Liu Maria V Deaconu Gabriela S Gheorghe Adriana M Iliesiu Ioan T Nanea Department of Internal Medicine and Cardiology Theodor Burghele Clinical Hospital Carol Davila University of Medicine and Pharmacy Bucharest Romania Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sci- ences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China

Objective To examine the relationship between tpeak- tend interval （Tpe） and Tpe/QT ratio with occurrence of ventricular premature beats （VPBs） and left ventricular remodeling in hypertension. Methods A total of 52 patients with mild to moderate essential hypertension were included, undergoing echocardiography and 24-hours Holter monitoring. Ventricular remodeling was assessed by left ventricular mass index （LVMI） using the Devereux formula and diastolic fimction by transmitral E and A wave velocities and E/A ratio. Tpe was measured in the precordial leads. The end of the T wave was set by the method of the tangent to the steepest descending slope of the T wave. Results Tpe and Tpe/QT in leads V2 （r = 0.33, P = 0.01; r = 0.27, P = 0.04 respectively） and V3 （r = 0.40, P = 0.002; r = 0.40, P = 0.003, respectively） correlated significantly with LVMI. A significant inverse relationship was observed between E/A ratio and QT （r = -0.33, P = 0.01）, Tpe in V3 （r = -0.39, P = 0.003） and Tpe/QT in V3 （r = -0.31, P = 0.02）. Tpe in V3, V5, mean Tpe and maximum Tpe with cut-offvalues of 60 ms, 59 ms, 62 ms and 71 ms, respectively, associated with the occurrence of ventricular premature beats. Conclusions The repolarization parameters Tpe interval and Tpe/QT ratio correlate with LVMI and indices of left ventricular diastolic function and show better predictive values than traditional parameters such as QT interval and QT dispersion. Lead V3 is the best lead for measuring Tpe and Tpe/QT. These ECG indices can therefore be used in clinical practice to monitor LV remodeling and predict occurrence of VPBs.

关键词： Hypertension Repolarization tpeak-tend Ventricular remodeling

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Meta-analysis of T-wave indices for risk stratification in myocardial infarction

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Journal of Geriatric Cardiology 2017年第12期14卷 776-779页

作者： Gary Tse Cheuk Wai Wong Meng-Qi GONG Lei MENG Konstantinos P Letsas Guang-Ping LI Paula Whittaker Aishwarya Bhardwaj Abhishek C Sawant William KK Wu Sunny Hei Wong Jayaprakash Shenthar Lap Ah Tse Martin CS Wong Adrian Baranchuk Gan-Xin YAN Tong LIU Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Second Department of Cardiology Laboratory of Cardiac Electrophysiology 'Evangelismos' General Hospital of Athens Athens Greece Division of Population Health Health Services Research and Primary Care School of Health Sciences University of Manchester United Kingdom Division of Cardiology Department of Internal Medicine State University of New York at Buffalo USA Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China Electrophysiology Unit Sri Jayadeva Institute of Cardiovascular Sciences and Research B G Road 9th Block Jayanagar Bangalore India JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China Division of Cardiology Kingston General Hospital Queen 's University Kingston Ontario Canada Lankenau Institute for Medical Research and Lankenau Medical Center Wynnewood Pennsylvania USA Beijing Anzhen Hospital Capital Medical University Beijing China

Ventricular tachy-arrhythmias are the commonest cause of sudden cardiac death in patients with ischemie heart dis- ease. It is estimated that up to 20% patients with acute myocardial infarction suffer from these *** i... 详细信息

关键词： Myocardial infarction Repolarization Sudden death tpeak-tend tpeak-tend/QT

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Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice

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World Journal of Clinical Cases 2015年第8期3卷 705-720页

作者： Yaniel Castro-Torres Raimundo Carmona-Puerta Richard E Katholi Facultad de Medicina Universidad de Ciencias Médicas Dr.Serafín Ruiz de Zárate Ruiz Cardiocentro Ernesto Che Guevara Southern Illinois University School of Medicine and Prairie Cardiovascular Consultants

Malignant cardiac arrhythmias which result in sudden cardiac death may be present in individuals apparently healthy or be associated with other medical conditions. The way to predict their appearance represents a challenge for the medical community due to the tragic outcomes in most cases. In the last two decades some ventricular repolarization(VR) markers have been found to be useful to predict malignant cardiac arrhythmias in several clinical conditions. The corrected QT, QT dispersion, tpeak-tend, tpeak-tend dispersion and Tp-e/QT have been studied and implemented in clinical practice for this purpose. These markers are obtained from 12 lead surface electrocardiogram. In this review we discuss how these markers have demonstrated to be effective to predict malignant arrhythmias in medical conditions such as long and short QT syndromes, Brugada syndrome, early repolarization syndrome, acute myocardial ischemia, heart failure, hypertension, diabetes mellitus, obesity and highly trained athletes. Also the main pathophysiological mechanisms that explain the arrhythmogenic predisposition in these diseases and the basis for the VR markers are discussed. However, the same results have not been found in all conditions. Further studies are needed to reach a global consensus in order to incorporate these VR parameters in risk stratification of these patients.

关键词： Electrocardiographic predictor Ventricular repolarization markers Ventricular fibrillation Sudden cardiac death QT interval Corrected QT interval QT dispersion tpeak-tend interval tpeak-tend QT ratio

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