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toxicological effects of Secondary Air Pollutants

Chemical Research in Chinese Universities 2023年第3期39卷 326-341页

作者： XIANG Wang WANG Weigang DU Libo ZHAO Bin LIU Xingyang ZHANG Xiaojie YAO Li GE Maofa State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular SciencesCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China College of Chemistry and Material Science Hebei Normal UniversityShijiazhuang 050024P.R.China

Secondary air pollutants,originating from gaseous pollutants and primary particulate matter emitted by natural sources and human activities,undergo complex atmospheric chemical reactions and multiphase *** gaseous pollutants represented by ozone and secondary particulate matter,including sulfates,nitrates,ammonium salts,and secondary organic aerosols,are formed in the atmosphere,affecting air quality and human *** paper summarizes the formation pathways and mechanisms of important atmospheric secondary ***,different secondary pollutants’toxicological effects and corresponding health risks are *** have shown that secondary pollutants are generally more toxic than primary ***,due to their diverse source and complex generation mechanism,the study of the toxicological effects of secondary pollutants is still in its early ***,this paper first introduces the formation mechanism of secondary gaseous pollutants and focuses mainly on ozone’s toxicological *** terms of particulate matter,secondary inorganic and organic particulate matters are summarized separately,then the contribution and toxicological effects of secondary components formed from primary carbonaceous aerosols are ***,secondary pollutants generated in the indoor environment are briefly ***,a comprehensive review of secondary air pollutants may shed light on the future toxicological and health effects research of secondary air pollutants.

关键词： Secondary pollutant Atmosphere toxicological effect Public health Particulate matter

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Source,migration,distribution,toxicological effects and remediation technologies of arsenic in groundwater in China

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China Geology 2023年第3期6卷 476-493页

作者： Zhen Wang Hua-ming Guo Hai-yan Liu Wei-min Zhang MOE Key Laboratory of Groundwater Circulation and Environmental Evolution China University of Geosciences(Beijing)Beijing 100083China School of Water Resources and Environment Engineering East China University of TechnologyNanchang 330032China School of Water Resources and Environment China University of Geosciences(Beijing)Beijing 100083China

Groundwater with high arsenic(As) content seriously threatens human life and health. Drinking high-As groundwater for a long time will lead to various pathological changes such as skin cancer, liver cancer,and kidney cancer. High-As groundwater has become one of the most serious environmental geological problems in China and even internationally. This paper aims to systematically summarize the sources,migration, distribution, toxicological effects, and treatment techniques of As in natural groundwater in China based on a large number of literature surveys. High-As groundwater in China is mainly distributed in the inland basins in arid and semi-arid environments and the alluvial and lacustrine aquifers in river deltas in humid environments, which are in neutral to weakly alkaline and strongly reducing *** content of As in groundwater varies widely, and As(Ⅲ) is the main form. The main mechanism of the formation of high-As groundwater in China is the reduced dissolution of Fe and Mn oxides under the action of organic matter and primary microorganisms, alkaline environment, intense evaporation and concentration, long-term water-rock interaction, and slow groundwater velocity, which promote the continuous migration and enrichment of As in groundwater. There are obvious differences in the toxicity of different forms of As. The toxic of As(Ⅲ) is far more than As(V), which is considered to be more toxic than methyl arsenate(MMA) and dimethyl arsenate(DMA). Inorganic As entering the body is metabolized through a combination of methylation(detoxification) and reduction(activation) and catalyzed by a series of methyltransferases and reductases. At present, remediation methods for high-As groundwater mainly include ion exchange technology, membrane filtration technology, biological treatment technology, nanocomposite adsorption technology, electrochemical technology, and so on. All the above remediation methods still have certain limitations, and it is urgent to d

关键词： High arsenic groundwater Source and distribution Enrichment mechanism Skin cancer Liver cancer Kidney cancer toxicological effect Remediation technology Ecological geological survey engineering Hydrogeological survey engineering

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Evaluation of the biological toxicity of fluorine in Antarctic krill

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Advances in Polar Science 2014年第1期25卷 38-45页

作者： ZHANG Ling LU Xiaoqi WANG Zhangmin QIN Liqiang LIN Zhiqin YUAN Linxi ZHANG Wen YIN Xuebin School of Earth and Space Science University of Science and Technology of China Suzhou Key Lab for Eco-safety and Human Health Suzhou Institute for Advanced StudyUniversity of Science and Technology of China Department of Nutrition and Food Hygiene School of Public HealthSoochow University Environmental Sciences Program Southern Illinois University Department of Orthopedics Research Institute Soochow University

Antarctic krill is a potentially nutritious food source for humans, but lfuorine （F） toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens：a control group, a krill treatment group （150 mg＆#183;kg-1 F）, and a sodium lfuoride （NaF） treatment group （150 mg＆#183;kg-1 F）. After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal lfuorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0＆#177;0.020 4 mg.L-1 and 2 709.8＆#177;301.9 mg＆#183;kg-1, respectively, compared with 0.043 8＆#177;0.005 5 mg＆#183;L-1 and 442.4＆#177;60.7 mg＆#183;kg-1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental lfuorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal lfuorosis did not change signiifcantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption.

关键词： Antarctic krill fluorine (F) fluorosis rat experiment toxicological effect

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Research progress and quality markers prediction analysis of Dysosma versipellis

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Traditional Medicine Research 2023年第3期8卷 36-50页

作者： Yuan-Hui Guo Peng Lu Jia-Xing He Bao-Nan Ma Ebuka-Olisaemeka Nwafor Wen-Xin Wang Chuan-Xin Liu Endocrine and Metabolic Disease Center First Affiliated Hospitaland College of Clinical Medicine of Henan University of Science and TechnologyMedical Key Laboratory of Hereditary Rare Diseases of HenanLuoyang Sub-center of National Clinical Research Center for Metabolic DiseasesLuoyang 471000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou 215009China College of Traditional Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing 100029China School of Health&Biomedical Sciences RMIT University–Bundoora CampusMelbourne 3083Australia School of Biological and Medical Engineering Beihang UnivesityBeijing 100083China

Dysosma versipellis is the rhizome of Bajiaolian in *** is a unique medicinal plant in China and it was the first to be recorded in Shennong’s Classic of Materia Medica(unknown author,25–220 C.E.).It has complex chemical components as well as complex,pharmacological and toxicological effects are *** on the recent research progress,the chemical constituents,pharmacological activities and toxicological effects of Dysosma versipellis were *** with the core concept of quality markers of traditional Chinese medicine,the prediction and analysis were carried out from the aspects of phytogenetics and the source pathway of specific chemical constituents,traditional medicinal properties,traditional efficacy,chemical composition measurability,blood components,and pharmacokinetics,in order to provide reference for further study of Dysosma versipellis.

关键词： Dysosma versipellis lignans flavonoids chemical composition pharmacological activity toxicological effect quality marker podophyllotoxin kaempferol quercetin

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