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tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway

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World Journal of Gastroenterology 2023年第44期29卷 5919-5934页

作者： Ruo-Chuan Sun Jing Li Ya-Xian Li Hui-Zhen Wang Emre Dal Ming-Liang Wang Yong-Xiang Li Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Oncological Sciences University of UtahSalt Lake CityUT 84112United States

BACKGROUND The role of tousled-like kinase 1(TLK1)in in gastric cancer(GC)remains *** To investigate the expression,biological function,and underlying mechanisms of TLK1 in *** We measured TLK1 protein expression levels and localized TLK1 in GC cells and tissues by western blot and immunofluorescence,*** transfected various GC cells with lentiviruses to create TLK1 overexpression and knockdown lines and established the functional roles of TLK1 through in vitro colony formation,5-ethynyl-2`-deoxyuridine,and Transwell assays as well as flow *** applied bioinformatics to elucidate the signaling pathways associated with *** performed in vivo validation of TLK1 functions by inducing subcutaneous xenograft tumors in nude *** TLK1 was significantly upregulated in GC cells and tissues compared to their normal counterparts and was localized mainly to the ***1 knockdown significantly decreased colony formation,proliferation,invasion,and migration but increased apoptosis in GC ***1 overexpression had the opposite *** revealed,and subsequent experiments verified,that the tumor growth factor-beta signaling pathway was implicated in TLK1-mediated GC *** in vivo assays confirmed that TLK1 promotes tumorigenesis in *** The findings of the present study indicated that TLK1 plays a crucial role in GC progression and is,therefore,promising as a therapeutic target against this disease.

关键词： Gastric cancer tousled-like kinase 1 Tumor growth factor-beta Tumour progression Targeted therapy

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