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Effects of walnut(Juglans regia L.)kernel extract and juglone on dopamine levels and oxidative stress in rats

Food Bioscience 2023年第1期51卷 906-913页

作者： Sener Cintesun Zeynep Ozman Abdurrahim Kocyigit Banu Mansuroglu Ismail Kocacaliskan Department of Molecular Biology and Genetics Faculty of Arts&ScienceYıldız Technical UniversityIstanbulTurkey Faculty of Medicine Department of Medical BiochemistryBezmialem Vakif UniversityIstanbulTurkey Institute of Health Sciences Department of Medical BiochemistryBezmialem Vakif UniversityIstanbulTurkey Advanced Research and Application Center of Traditional and Complementary Medicine Bezmialem Vakif UniversityIstanbulTurkey

3,4-dihydroxyphenethylamine(dopamine)is a neurotransmitter that has vital functions in the nervous *** metabolism and reactive oxygen species(ROS)production are highly related *** present study aims to evaluate the effects of walnut(Juglans regia L.)extract(WE)and 5-hydroxy-1,4 naphthoquinone(juglone)on dopamine levels and oxidative *** this purpose,WE and juglone were administered to *** and brain dopamine levels,total oxidant status(TOS),and total antioxidant status(TAS)were measured after 21 *** oxidative stress index(OSI)was ***(300 mg/kg)significantly increased brain dopamine *** and juglone reduced oxidative stress in liver and brain tissues compared to *** results revealed that WE and juglone might have a neuroprotective *** studies are needed to extensively investigate the molecular mechanism of the effects of herbal extracts and phenolic compounds on brain health.

关键词： Dopamine Walnut Juglone total antioxidant status total oxidant status Oxidative stress

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Therapeutic Uses of Lycium barbarum Polysaccharides on Idiopathic Thrombocytopenic Purpura Mice via Inhibition of Oxidative Stress

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Journal of Biosciences and Medicines 2016年第8期4卷 17-23页

作者： Chengqiang Jin Haixin Dong Jianwei Zhou Shuhua Lu Xiaxia Yang Zhenwen Qian Yanxia Jia Analytical Section of Attached Hospital of Jining Medical College Jining China Radiology Department of Jining No. 1 People’s Hospital Jining China

The aim of the present study was to investigate the effect of Lycium barbarum polysaccharides (LBP) on the treatment of ITP mice and to explore its mechanism. Forty idiopathic thrombocytopenic purpura (ITP) mice were divided randomly into a model control group and LBP groups I, II, III and IV. ITP mice in LBP groups I, II, III, and IV were administered LBP at four different doses (50, 100, 200 and 400 mg·kg-1·d-1, respectively) for 7 days by gavage. Blood samples were collected from the tail veins of the mice after treatment. Platelet counts were determined, and the total antioxidant status (TAS), total oxidant status (TOS) were measured with ELISA kits. The platelet count was (30.28 ± 13.42) × 109/L in the model control group, and the number of platelets in all LBP groups was higher than that in the model control group. The platelet count increased, and it reached (67.09 ± 10.81) × 109/L in LBP group I;the platelet counts in the other three groups increased significantly compared to LBP group I, and they did not differ significantly. TAS concentrations in the LBP groups were significantly increased compared to the model control group, whereas TOS concentrations were significantly decreased. Taken together, these results indicate that LBP is effective at increasing the number of platelet (PLT), and LBP may treat ITP mice via suppressing oxidative stress.

关键词： Lycium barbarum Polysaccharides Idiopathic Thrombocytopenic Purpura total antioxidant status total Oxidant status

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Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis

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Health 2013年第11期5卷 1924-1928页

作者： Stefan Lukac Terezia Kalnovicova Jana Muchova Institute of Medical Chemistry Biochemistry and Clinical BiochemistryFaculty of MedicineComenius UniversityBratislavaSlovakia Department of Neurology Faculty of MedicineComenius UniversityBratislavaSlovakia

Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system (CNS) through demyelination and neurodegeneration. Several lines of evidence support a role for oxidative and nitrative stress (OS and NS) in pathogenesis of multiple sclerosis. The mechanism of influence of OS and NS on blood-brainbarrier (BBB) has critical importance for evaluating antioxidant therapies. As far as we know, markers of oxidative and nitrative stress in MS patients have been investigated independently for their relationship with the state of the blood-brain-barrier. Blood plasma samples of 58 patients with relapse-remitting MS (RRMS) with normal (Group A, n = 48, 36.2 ± 10.5 years) and damaged BBB (Group B, n = 10, 38.2 ± 11.2 years) and of 44 healthy controls (39.2 ± 14.9 years) were analyzed. TAS (total antioxidant plasma status), lipoperoxides, protein carbonyls, 3-nitrotyrosine and uric acid were evaluated in each group. Our results confirmed decreased TAS (Group A: 1.35 ± 0.55 mmol/l, P e level of lipoperoxidation positively correlated with the state of BBB (P of protein’s carbonyls (A: 0.48 ± 0.11 nmol/mg protein, P nmol/l, P ed damage to plasma proteins, what was confirmed by their positive mutual correlation (P The level of uric acid was physiological and correlated negatively with protein’s carbonyls (P 0.05) while there was no significant relationship with 3-nitotyrosine. The results suggest the role of this antioxidant in the protection of the proteins against OS what was confirmed by its positive correlation with TAS

关键词： Relapsing Remiting Multiple Sclerosis Oxidative Stress Nitrative Stress Blood-Brain-Barrier total antioxidant status 3-Nitrotyrosine Protein Carbonyls Lipoperoxides Uric Acid

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