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Serum Levels of Prostate Specific Antigen Parameters among Male Patients with Lepromatous Leprosy in Edo State, Nigeria

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Health 2021年第9期13卷 920-933页

作者： Babatunde Ishola Gabriel Adejumo David Osebhor Uchechukwu Dimkpa Usman Itakure Abdulkadir Oladimeji Nasiru Abdulrahman Uzor Simon Kelechi Ncheta Nkwazema Noreen Ebelechukwu Agbapuonwu Grace Umahi-Ottah Medical Laboratory Science Department University of Benin Benin City Nigeria Physiology Department Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Department of Medical Laboratory Science College of Health Sciences and Technology Markafi Kaduna State Nigeria Department of Medical Laboratory Science College of Health Technology Offa Kwara State Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Medical Laboratory Science Department National Ear Care Centre Kaduna Kaduna State Nigeria Department of Nursing Nnamdi Azikwe University Akwa Nigeria Department of Physiology Ebonyi State University Abakaliki Nigeria

Aim: This study is aimed at determining the total psa (tpsa), free psa (fpsa) concentrations and free to total psa ratio (f/tpsa) and their utility in prostate cancer (PCa) risk stratification among male lepromatous leprosy patients in Edo state, Nigeria. Methods: Forty participants and thirty controls participated in this study. A structured questionnaire was administered to each participant to elicit details such as their personal data, age, sex, residence, medications, alcohol consumption, smoking habit, length of time of diagnosis, sexual activities, as well as the history of any other underlying diseases. Blood samples were collected from the participants. total and free psa concentrations in the samples were measured using ELISA method. Results: Significantly (p = 0.042) higher serum fpsa among the leprosy patients (0.22 ± 0.12 ng/ml) compared with the healthy controls (0.17 ± 0.09 ng/ml). There were no significant (p = 0.055) difference in the mean tpsa between the leprosy patients (2.69 ± 2.25 ng/ml) compared with the control (1.95 ± 0.69 ng/ml). Similarly, no significant (p = 0.548) difference was observed in psa ratio between the control (0.08 ± 0.04) and the leprosy patients (0.09 ± 0.03). Conclusion: Our study indicated no significant differences in tpsa and f/tpsa between the leprosy patients and their healthy control. Elevated tpsa as well as f/tpsa levels that fell within the high risk zones of PCa were more prevalent among patients aged ≥ 70 years, not married, who rarely had sexual intercourse and those with longer disease duration.

关键词： Serum Prostate Cancer total psa Free psa Male Leprosy

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