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Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes

引用

Bioactive Materials 2022年第10期7卷 372-387页

作者： Bitao Lu Enling Hu Ruiqi Xie Kun Yu Fei Lu Rong Bao Chenhui Wang Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing Village BeiBei DistrictChongqing400715China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing University55 South Daxuecheng RoadChongqing401331China

Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased *** by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type ***_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound *** bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 ***,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC *** study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment.

关键词： torpedoes-inspired Microcluster colloidosomes Magnetic guidance Disintegration Hemostasis

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