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Acid-induced topological morphology modulation of graphitic carbon nitride homojunctions as advanced metal-free catalysts for OER and pollutant degradation

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Journal of Materials Science & Technology 2021年第27期86卷 210-218页

作者： Hua-Wei Zhang Yi-Xin Lu Bo Li Gui-Fang Huang Fan Zeng Yuan-Yuan Li Anlian Pan Yi-Feng Chai Wei-Qing Huang Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha410082China College of Materials Science and Engineering Hunan UniversityChangshaHunan410082China School of Physics and Electronics Science Hunan University of Science and TechnologyXiangtan411201China

topological morphology that dominates the surface electronic properties of nanostructures plays a key role in producing desired materials for versatile functions and applications in many fields,but its modulation for specific functions remains a big ***,we report an acid-induced method to prepare S-doped graphitic carbon nitride/graphitic carbon nitride(S-CN/CN)homojunction by simply pyrolyzing a supramolecular precursor synthesized from melamine and H_(2)SO_(4).The topological morphology and electronic structure of CN homojunction can be easily adjusted only by changing the ratio of raw ***,the topological morphology of S-CN/CN homojunction can be further adjusted from hollow cocoon to 2D nanosheets by changing the annealing *** optimized S-CN/CN homojunction shows highly efficient in charge transfer and separation and exhibits superior OER activity and high ability to degrade organic ***,S-CN/CN nanosheets only demand low overpotential of301 m V to drive a current density of 10 m Acm^(-2)in 1 M KOH media,and the corresponding Tafel slope is only 57.71 m V/dec,which is superior to the most advanced precious metal Ir O_(2)***,under visible light irradiation,its photodegradation kinetic rate of Rh B is 2.38,which is 47.6 times higher than that of bulk *** work provides useful guidance for designing and developing efficient multifunctional metal-free catalysts.

关键词： topological morphology Acid-induced Molecular self-assembly S-CN/CN homojunction OER

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Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic andosteogenic niches in osteoporosis

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Bioactive Materials 2024年第9期39卷 354-374页

作者： Guoyang Zhang Yuhao Kang Jizhao Dong c Dingyi Shi Yu Xiang Haihan Gao Zhiqi Lin Xiaojuan Wei Ren Ding Beibei Fan Hongmei Zhang Tonghe Zhu Liren Wang Xiaoyu Yan Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No.600 Yishan RoadShanghai200233China Shanghai Jiao Tong University School of Medicine No.227 South Chongqing RoadShanghai200025China Multidisciplinary Centre for Advanced Materials Institute for Frontier Medical TechnologySchool of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620China Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine Department of OrthopedicsNo.181 Youyi RoadShanghai201900China Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine Department of PharmacyNo.181 Youyi RoadShanghai201900China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Regenerative Sports Medicine Lab of the Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China

Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite thedevelopment of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their lowbioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. Thiscalls for an urgent need for more effective bone-affinity drug delivery systems. In this study, we produced hybridstructures with bioactive components and stable fluffy topological morphology by cross-linking calcium andphosphorus precursors based on mesoporous silica to fabricate nanoadjuvants for AL delivery. The subsequentgrafting of -PEG-DAsp8 ensured superior biocompatibility and bone targeting capacity. RNA sequencing revealedthat these fluffy nanoadjuvants effectively activated adhesion pathways through CARD11 and CD34 molecularmechanisms, hence promoting cellular uptake and intracellular delivery of AL. Experiments showed that smalldoseAL nanoadjuvants effectively suppress osteoclast formation and potentially promote osteogenesis. In vivoresults restored the balance between osteogenic and osteoclastic niches against osteoporosis as well as theconsequent significant recovery of bone mass. Therefore, this study constructed a drug nanoadjuvant withpeculiar topological structures and high bone targeting capacities, efficient intracellular drug delivery as well asbone bioactivity. This provides a novel perspective on drug delivery for osteoporosis and treatment strategies forother bone diseases.

关键词： Osteoporosis nanoadjuvants topological morphology bone niches Adhesion

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