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Study of microbes on skin lesion and a control-topical treatment trial of atopic dermatitis

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Study of microbes on skin lesion and a control-topical treat...

Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity

International Forum 2003 Academic Conference of Dermatology of the Integration of TCM with Western Medicine

作者： Liu Yongsheng, You Liping, Yang Dingquan, Li Yanliu Ma Lin, Xin Huan, Deparment of Dermatology , China-Japan Friendship hospital,Beijing 100029, China Department of Dermatology, Beijing Children hospital, Beijing 100045,China )

To study the microbial infection of skin lesion, drug-sensitive ofstaphylococcal and topical treatment of atopic dermatitis (AD) in China, 71cases of AD patients were diagnosed by the criteria of Hanifin-Rajka's diag-nostic features and Williams' diagnostic criterion at the departments of Chi-na-Japan Friendship hospital and Beijing Children Hospital in 11/2001-3/2002. We used microbial media for bacteria culture and fungi and mi-

关键词： dermatitis, atopic microbe topical treatment

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World Journal of Gastroenterology 2006年第38期12卷 6203-6206页

作者： Panagiotis Katsinelos Jannis Kountouras George Paroutoglou Athanasios Beltsis Grigoris Chatzimavroudis Christos Zavos Taxiarchis Katsinelos Basilis Papaziogas Department of Endoscopy and Motility Unit Central Hospital Thessaloniki Greece Department of Gastroenter- ology Second Medical Clinic Aristotle University of Thessaloniki Ippokration Hospital Thessaloniki Greece

AIM： To investigate the efficacy of topical application of 0.5% nifedipine ointment in healing acute anal tissue and preventing its progress to chronicity. METHODS： Thirty-one patients （10 males, 21 females） with acute anal fissure from September 1999 to January 2005 were treated topically with 0.5% nifedipine ointment （t.i.d.） for 8 wk. The patients were encouraged to follow a high-fiber diet and assessed at 2, 4 and 8 wk post-treatment. The healing of fissure and any side effects were recorded. The patients were subsequently followed up in the outpatient clinic for one year and contacted by phone every three months thereafter, while they were encouraged to come back if symptoms recurred. RESULTS： Twenty-seven of the 31 patients completed the 8-wk treatment course, of them 23 （85.2%） achieved a complete remission indicated by resolution of symptoms and healing of fissure. Of the remaining four unhealed patients （14.8%）, 2 opted to undergo lateral sphincterotomy and the other 2 to continue therapy for four additional weeks, resulting in healing of fissure. All the 25 patients with complete remission had a mean follow-up of 22.9 ± 14 （range 6-52） too. Recurrence of symptoms occurred in four of these 25 patients （16%） who were successfully treated with an additional 4-wk course of 0.5% nifedipine ointment. Two of the 27 （7.4%） patients who completed the 8-wk treatment presented with moderate headache as a side effect of nifedipine. CONCLUSION： topical 0.5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity.

关键词： Acute anal fissure Nifedipine Calcium channel blockers topical treatment

Pharmacist’s Evaluation of Natural Ingredients in topical Products for Rheumatoid Arthritis

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Pharmacology & Pharmacy 2022年第8期13卷 273-284页

作者： Hanna Tillman Juliana Gassmann Shelby Stensgard Alex Nguyen Nicholas Tieu Markus Melbardis Hayden Gharibyar Remedy Products LLC Fort Collins CO USA

Inflammatory diseases such as rheumatoid arthritis (RA) can lead to chronic pain and joint deformity. First line treatment includes disease-modifying antirheumatic drugs (DMARDs) to slow disease progression, but RA patients are often left with debilitating symptoms. This article explores alternative topical and naturally based options to treat RA symptoms, with supporting evidence for their use. Considered options include Aloe vera, Perillyl Alcohol (POH), Aleurites moluccana, Calendula officinalis extract (quercetin), Achyranthes species, Guizhi Shaoyao Zhimu, Curcumin (turmeric), Wutou, Radix paeoniae extract (Paeoniflorin), Tripterygium wilfordii Hook F (TWHF), Capsaicin, Cannabinoids (CBD), and Berberine. Many of these products show promising data for supplemental treatment of RA through various mechanisms, with CBD and TWHF having the most robust evidence supporting their use.

关键词： Rheumatoid Arthritis Natural Ingredient topical treatment Anti-Inflammatory Alternative treatment

Critical review of topical management of oral hairy leukoplakia

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World Journal of Clinical Cases 2014年第7期2卷 253-256页

作者： Cláudia B Brasileiro Mauro Henrique NG Abreu Ricardo A Mesquita Department of Oral Surgery and Pathology School of DentistryUniversidade Federal de Minas GeraisPampulha31270-901Belo Horizonte/MGBrazil Department of Community and Preventive Dentistry School of DentistryUniversidade Federal de Minas GeraisPampulha31270-901Belo Horizonte/MGBrazil

Oral hairy leukoplakia(OHL) is a disease associated with Epstein-Barr virus and human immunodeficiency virus infections. OHL is usually an asymptomatic lesion, but in some cases treatment is recommended to reestablish the normal characteristics of the tongue, to eliminate pathogenic microorganisms, to improve patient comfort and for cosmetic reasons. Proposed treatments for this condition include surgery, systemic antiviral treatment and topical management. topical treatment is an inexpensive and safe therapy that is easy to apply, noninvasive, free of systemic adverse effects and effective over a long period of time. The aim of this study was to present a review of the literature for topical therapy for OHL. Gentian violet, retinoids, podophyllin, acyclovir and podophyllin associated with topical antiviral drugs were used to treat OHL. Reports with this focus are limited, and since 2010, no new studies have been published that discuss the efficacy of topical treatments for OHL. Podophyllin with acyclovircream was found to be effective, causing regression of lesions with no recurrences. Additional searches are necessary to provide clinical evidence of topical man agement effectiveness.

关键词： Oral hairy leukoplakia Human immunodeficiency virus infection topical treatment topical agents Recurrence rate