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Current scenario of traditional medicines in management of diabetic foot ulcers:A review

World Journal of Diabetes 2023年第1期14卷 1-16页

作者： Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande Department of Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India

Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often *** have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound *** have been the leading cause for non-traumatic amputations of part or whole of the *** medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading *** in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in ***,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing *** process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without *** modulation with various dressings and techniques are often a costly *** aspects of the topical therapy with modern/Western medicines are frequently not *** of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/*** Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood *** medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound *** is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic *** natural and plant derived products(e.g

关键词： Diabetic foot infections Diabetic foot ulcers Management Traditional medicines topical agents Wound healing

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Role of an acidic environment in the treatment of diabetic foot infections:A review

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World Journal of Diabetes 2021年第9期12卷 1539-1549页

作者： Basavraj Nagoba Ajay Gavkare Abhijit Rayate Sachin Mumbre Arunkumar Rao Basavraj Warad Neeta Nanaware Nawab Jamadar Department of Microbiology MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Physiology MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Surgery MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413001MaharashtraIndia Department of Orthopedics MIMSR Medical CollegeLatur 413512India Department of Physiology Government Medical CollegeLatur 413512MaharashtraIndia Department of Anesthesiology MIMSR Medical CollegeLatur 413512MaharashtraIndia

Management of diabetic foot ulcers is the biggest challenge to the clinician,as conventional antibiotic therapies and local wound care have their own *** are not effective for control of infections and promotion of healing because of cytotoxic *** view of cytotoxicity of routinely used topical antiseptic agents,this article focuses on the search of an ideal topical antiseptic agent that is safe and effective in controlling infectious agents and also in promoting the healing *** review focuses on the use of various acids such as citric,acetic,hyaluronic,and hypochlorous acids as topical agents in diabetic foot *** article also focuses on the different roles of acids in the treatment of diabetic foot infections.

关键词： Diabetic foot ulcer Infection Management topical agents Acids Role of acids

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Critical review of topical management of oral hairy leukoplakia

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World Journal of Clinical Cases 2014年第7期2卷 253-256页

作者： Cláudia B Brasileiro Mauro Henrique NG Abreu Ricardo A Mesquita Department of Oral Surgery and Pathology School of DentistryUniversidade Federal de Minas GeraisPampulha31270-901Belo Horizonte/MGBrazil Department of Community and Preventive Dentistry School of DentistryUniversidade Federal de Minas GeraisPampulha31270-901Belo Horizonte/MGBrazil

Oral hairy leukoplakia(OHL) is a disease associated with Epstein-Barr virus and human immunodeficiency virus infections. OHL is usually an asymptomatic lesion, but in some cases treatment is recommended to reestablish the normal characteristics of the tongue, to eliminate pathogenic microorganisms, to improve patient comfort and for cosmetic reasons. Proposed treatments for this condition include surgery, systemic antiviral treatment and topical management. topical treatment is an inexpensive and safe therapy that is easy to apply, noninvasive, free of systemic adverse effects and effective over a long period of time. The aim of this study was to present a review of the literature for topical therapy for OHL. Gentian violet, retinoids, podophyllin, acyclovir and podophyllin associated with topical antiviral drugs were used to treat OHL. Reports with this focus are limited, and since 2010, no new studies have been published that discuss the efficacy of topical treatments for OHL. Podophyllin with acyclovircream was found to be effective, causing regression of lesions with no recurrences. Additional searches are necessary to provide clinical evidence of topical man agement effectiveness.

关键词： Oral hairy leukoplakia Human immunodeficiency virus infection topical treatment topical agents Recurrence rate

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